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Bosch-Capblanch, Ross); Swiss Tropical and Public Health Institute ( Bosch-Capblanch, Ross); Harvard University ( Oduwole) Informal training to enhance the traditional and religious leaders knowledge of vaccination and their leadership role can empower them to be good influencers for childhood vaccination. They constitute untapped resources in the community to boost routine immunisation. In Nigeria, traditional leaders lead ward development committees, which enable community participation within the primary healthcare system. These influential and respected community members have, for example, supported the scale-up of polio campaigns in the northern part of the country. Thus, having identified traditional and religious leaders (TRLs) as potential public health change agents, this study aimed to assess the effect of training them to support routine immunisation (RI) for the purpose of improving uptake of childhood vaccines in Cross River State, Nigeria. ....