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How disease-causing microbes load their tiny syringes to prep an attack

Tracking individual proteins in bacterial cells reveals a shuttle-bus system to load tiny syringes that inject our cells with havoc-wreaking proteins. ....

Salt Lake City , United States , University Of Utah , Andreas Diepold , Kelly Hughes , Max Planck Institute , Terrestrial Microbiology ,

Pathogenic bacteria use molecular 'shuttle services' to fill their injection apparatus with the right product

Pathogenic bacteria use molecular 'shuttle services' to fill their injection apparatus with the right product
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Nordrhein Westfalen , Andreas Diepold , Ulrike Endesfelder , Stephan Wimmi Alexander Balinovic , Stephan Wimmi , Max Planck Institute In Marburg , University Of Bonn , Max Planck Institute , Carnegie Mellon University In Pittsburgh , University In Bonn , Alexander Balinovic , Nature Microbiology , Terrestrial Microbiology , Carnegie Mellon University ,

Bacteria adapt syringe apparatus to changing conditions


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IMAGE: In order to increase survival chances in contact to eukaryotic host cells, both symbiotic and pathogenic bacteria have developed methods to influence host cell behavior. The type III secretion system.
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Credit: Max Planck Institute for Terrestrial Microbiology
Basic, acidic, basic again: for pathogenic bacteria such as Salmonella, the human digestive tract is a sea change. So how do the bacteria manage to react to these changes? A team of researchers from the Max Planck Institute for Terrestrial Microbiology in Marburg led by Andreas Diepold has now provided a possible explanation: pathogenic bacteria can change components of their injection apparatus on the fly - like changing the tires on a moving car - to enable a rapid response. ....

Stephan Wimmi , Ulrike Endesfelder , Andreas Diepold , Nature Communications , Max Planck Institute For Terrestrial Microbiology , Max Planck Institute , Terrestrial Microbiology , ஆண்ட்ரியாஸ் டைபோல்ட் , இயற்கை தகவல்தொடர்புகள் , நிலப்பரப்பு நுண்ணுயிரியல் ,