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RICE UNIVERSITY: Cancer 'guardian' breaks bad with one switch – India Education,Education News India,Education News

Study shows how mutant protein clusters drive disease-causing aggregates
A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is more damaging than previously known.
The ubiquitous p53 protein in its natural state, sometimes called “the guardian of the genome,” is a front-line protector against cancer. But the mutant form appears in 50% or more of human cancers and actively blocks cancer suppressors.
Researchers led by Peter Vekilov at the University of Houston (UH) and Anatoly Kolomeisky at Rice University have discovered the same mutant protein can aggregate into clusters. These in turn nucleate the formation of amyloid fibrils, a prime suspect in cancers as well as neurological diseases like Alzheimer’s. ....

University Of Houston , United States , Rice University , University Of Texas , David Yang , Navin Varadarajan , Aram Davtyan , Michelle Barton , Mohsen Fathi , Arash Saeedi , Alena Klindziuk , Peter Vekilov , Michael Sherman , Kolomeisky Research Group Rice University , Rice Department Of Chemistry , National Science Foundation , Kolomeisky Research Group , University Of Texas Medical Branch At Galveston , Anatoly Kolomeisky At Rice University , Oregon Health Science University , Research Institute Of Texas , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Research Programs , Sealy Center , Melanoma Research Alliance ,

Cancer 'guardian' breaks bad with one switch

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IMAGE: A model produced by scientists at Rice University shows the conformational changes caused by a mutation in the cancer-fighting p53 protein. At top left, the red box highlights the aggregation-prone.
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Credit: Kolomeisky Research Group/Rice University
HOUSTON - (March 4, 2021) - A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is more damaging than previously known.
The ubiquitous p53 protein in its natural state, sometimes called the guardian of the genome, is a front-line protector against cancer. But the mutant form appears in 50% or more of human cancers and actively blocks cancer suppressors. ....

University Of Houston , United States , Rice University , University Of Texas , David Yang , Navin Varadarajan , Aram Davtyan , Stephen Greenwell , Michelle Barton , Mohsen Fathi , Arash Saeedi , Mike Williams , Alena Klindziuk , Peter Vekilov , Jeff Falk , Michael Sherman , Kolomeisky Research Group Rice University , Rice Department Of Chemistry , National Science Foundation , Kolomeisky Research Group , University Of Texas Medical Branch At Galveston , Anatoly Kolomeisky At Rice University , Baker Institute For Public , Oregon Health Science University , Research Institute Of Texas , University Of Texas Md Anderson Cancer Center ,