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Melanoma patients respond to immunotherapy after changes to gut microbiome


Findings were published in Science.
The modeling technique invented by Andrey Morgun of the OSU College of Pharmacy and Natalia Shulzenko of Oregon State’s Carlson College of Veterinary Medicine is known as transkingdom network analysis.
The human gut microbiome is a community of more than 10 trillion microbial cells from about 1,000 different bacterial species, and transkingdom network analysis integrates multiple types of “omics” data – metagenomic, metabolomic, lipidomic, proteomic, etc. – in determining how interactions among specific types of gut microbes help or hinder biological functions in the host.
In this case, the microbial interactions involved how well the body responds to a type of cancer treatment known as anti-programmed cell death protein therapy, abbreviated to anti-PD-1 therapy. It allows immune cells to react more strongly to cancer. ....

Diwakar Davar , Natalia Shulzenko , Amiran Dzutsev , Hassane Zarour , Giorgio Trinchieri , Richard Rodrigues , National Institute Of Health , National Cancer Institute , University Of Pittsburgh , College Of Pharmacy , Oregon State Carlson College Of Veterinary Medicine , Oregon State University , Andrey Morgun , Oregon State , Carlson College , Veterinary Medicine , National Institute , Melanoma Patients , Gut Microbiome , Statistical Modeling , திவாகர் தவர் , ரிச்சர்ட் ரோட்ரிகஸ் , தேசிய நிறுவனம் ஆஃப் ஆரோக்கியம் , தேசிய புற்றுநோய் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் , கல்லூரி ஆஃப் மருந்தகம் ,