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Researchers reveal how protein modifications power T cells

This method is a major leap forward for scientists investigating how proteins do their jobs in the immune system. “This method basically creates an entire new ....

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New method rapidly reveals how protein modifications power T cells

New method rapidly reveals how protein modifications power T cells
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Rajan Burt , Mudra Hegde , Matthew Balakar , Natan Pirete , Rachela Gottschalk , Davidr Liu , Patrickh Kennedy , Mariai Matias , Amin Alborzian Deh Sheikh , Johng Doench , Alexanderc Jones , Alexandrac Newton , Patrickg Hogan , Gregory Newby , Suzie Alarc , Global Autoimmune Institute Assistant Professor Samuel Myers , Laboratory For Immunochemical Circuits , Research Technician Patrick Kennedy , Jolla Institute For Immunology , Supplementary Data File , Nature Methods , Immunochemical Circuits , Technician Patrick Kennedy , Generation Sequencing Core , Jonathan Levy , Tamia Little ,

Researchers reveal how protein modifications power T cells

Researchers reveal how protein modifications power T cells
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San Diego , United States , Alexandrac Newton , Gregory Newby , Natan Pirete , Davidr Liu , Johng Doench , Rachela Gottschalk , Mariai Matias , Amin Alborzian Deh Sheikh , Suzie Alarc , Rajan Burt , Alexanderc Jones , Matthew Balakar , Mudra Hegde , Patrickg Hogan , Jolla Institute For Immunology Flow Cytometry Core , Research Technician Patrick Kennedy , National Institutes Of Health , Howard Hughes Medical Institute , National Science Foundation Graduate Research Fellowship Program , Jolla Institute For Immunology , Stem Cell Network Jump Start Award , Global Autoimmune Institute Assistant Professor Samuel Myers , Laboratory For Immunochemical Circuits , Jolla Institute ,

A subtle change in the DNA may predispose to polyneuropathy after gut infection

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IMAGE: Patients with GBS characteristically produce autoantibodies to sialic acid-containing glycolipids called gangliosides present in neuronal cells. These autoantibodies are thought to bind to gangliosides present on the surface of neurons,.
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Credit: Department of Immunology, TMDU
Tokyo, Japan - Guillain-Barré syndrome is an infamous autoimmune neuropathy, yet genetic variants predisposing individuals to this disease have yet to be described. In a new study, researchers from Tokyo Medical and Dental University (TMDU) discovered two novel genetic variants in a protein made by antibody-forming immune cells, providing a mechanism for the development of the disease.
The body s immune system is supposed to fight off invaders; however, in autoimmune diseases this defense goes rogue and attacks the host instead through the production of autoantibodies. Guillain-Barré syndrome (GBS) is an acutely developing, autoimmune peripheral neurop ....

Takeshi Tsubata , Amin Alborzian Deh Sheikh , Tokyo Medical , Dental University , Professor Takeshi , Amin Alborzian Deh , தகேஷி ட்சுபதட , டோக்கியோ மருத்துவ , டெஂடல் பல்கலைக்கழகம் , ப்ரொஃபெஸர் தகேஷி ,