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Autumn Vavrick and Dante Impressive in the USEF Children Dressage National Championship

Autumn Vavrick and Dante Impressive in the USEF Children Dressage National Championship
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Study: WFFS Found in 21 Breeds – The Horse


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New research has revealed the Warmblood fragile foal syndrome (WFFS) allele in 21 breeds. The study, an international collaboration led by UC Davis Veterinary Genetics Laboratory Director Rebecca Bellone, PhD, screened more than 4,000 horses from 38 horse breeds in the United States and Europe.
Affected breeds were mainly Warmbloods, with the highest carrier frequencies (17%) observed in Hanoverians and Danish Warmbloods. Researchers did not detect the allele in two Warmblood breeds, the Swedish Warmblood and Zangersheide Warmblood, but sample sizes for both breeds in this study were small (16 and 10, respectively). The average WFFS carrier frequency across all Warmbloods tested was 11%. Non-Warmblood breeds included Haflinger, American Sport Pony, and Knabstrupper. The WFFS allele had previously been reported at a low frequency in Thoroughbreds (2.4% carrier frequency in 716 Thoroughbreds tested). ....

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Thirty-eight breeds tested for gene variant behind Warmblood fragile foal syndrome


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The skeleton of the Arabian stallion Bairactar Or. Ar. (1813-1838) in the Stud Museum Offenhausen in Germany. A tooth from this skeleton was used for DNA analysis, and he was eliminated as the purported source of Warmblood fragile foal syndrome. Photo: Stephan Kube
A study in which 4081 horses from 38 breeds were tested for the gene responsible for Warmblood fragile foal syndrome found an overall prevalence of 4.9%.
Warmblood fragile foal syndrome is a recessive disorder, caused by a variant in the PLOD1 gene. Being recessive, it must be inherited from each parent for the condition to emerge in foals.
Affected foals are either naturally aborted, stillborn, or euthanized. The distressing syndrome causes defects in connective tissue, meaning affected foals have hyper-extendible, abnormally thin, fragile skin that tears easily. ....

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