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The Lancet Global Health: Pregnant women excluded from three-quarters of COVID-19 treatment trials

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Pregnant women are among those most in need of safe and effective therapies against COVID-19, but they are routinely excluded from the majority of clinical treatment trials, according to authors of an opinion piece based on a review of international trial registry data, published in
The Lancet Global Health journal.
Strikingly, three-quarters of COVID-19 trials reviewed specifically excluded expectant mothers, even though they were investigating medications and vitamins that already have a relatively favourable safety profile during pregnancy, or that are already used in pregnant women.
In the Viewpoint, authors raise concerns that the ongoing exclusion of pregnant women will result in lost opportunities to ensure the effectiveness and safety of treatments in expectant mothers who may be at increased risk of severe outcomes from COVID-19 illness. They argue that given the scale of the pandemic and those that will inevitably follow, there is a public hea ....

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Pregnant women excluded from three-quarters of COVID-19 treatment trials

Pregnant women excluded from three-quarters of COVID-19 treatment trials
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Call for pregnant women to be included in Covid-19 trials

Pregnant women are at greater risk of more serious complications but are routinely excluded from research
16 December 2020 • 11:30pm
Pregnant women are routinely excluded from trials
Credit: Dobrila Vignjevic /iStockphoto
Leading researchers have backed calls for pregnant women to be included in trials for Covid-19 treatments, warning they are at higher risk of more serious complications of the disease.
A study in the Lancet Global Health reviewed nearly 900 clinical trials into treatments for the virus and found that around three quarters explicitly exclude pregnant women - this is despite the fact that many are testing existing drugs that have already been shown to be safe for mothers and their unborn babies. ....

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