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Biomarker Identification Drives Research and Drug Development in NSCLC and SCLC

Ranee Mehra, MD, and colleagues detail treatment updates across lung cancer subtypes, including navigating the array of available ALK inhibitors in NSCLC. ....

United States , University Of Maryland , Samuel Rosner , Ranee Mehra , University Of Maryland Medical System , National Comprehensive Cancer Network , Stewart Greenebaum Comprehensive Cancer Center , Hematology Medical Oncology Fellowship Program , Science Summit , Neck Medical Oncology , Medical Oncologyat , Maryland Medical System , Hematology Medical Oncology Fellowship , Displays Mixed Results , Though Interest , Non Small Cell Lung Cancer , Small Cell Lung Cancer , Immunotherapy Approaches , Kras G12c Mutated Nsclc , Alk Inhibitors , Katherinea Scilla ,

Less is more: ALK inhibitors increase exposed ALK expression

Researchers at Boston Children s Hospital and Harvard Medical School have explored the possibility of using anaplastic lymphoma kinase (ALK) as a target for the application of ALK.CAR T cells to treat neuroblastoma, the most common and deadliest tumor of infancy. ....

United States , Harvard Medical School , Boston Children , Boston Childrens Hospital , Alk Cart Cells , Alk Inhibitors ,

ALK Inhibitor Alectinib Shows DFS Benefit in Early NSCLC

Interim findings from the ALINA trial show improved DFS with alectinib in the adjuvant setting vs chemotherapy in resected stage IB-IIIA NSCLC. But will early DFS results extend to overall survival? ....

University Of Chicago , United States , Marina Garassino , Peter Maccallum Cancer Centre , Thoracic Oncology Program , European Society For Medical Oncology , Ben Solomon , European Society , Medical Oncology , Annual Meeting , Lung Cancer , Ung Carcinoma , Ancer Lung , Non Small Cell Lung Cancer , Anaplastic Lymphoma Kinase Alk Inhibitor , Alk Inhibitors , Anaplastic Lymphoma Kinase Alk , Lk Tyrosine Kinase Receptor , D246 Cluster Of Differentiation 246 , Malignant Head And Neck Neoplasm , Adjuvant Setting , Malignant Secondary Lung Neoplasm , Etastasis Lung , Small Cell Lung Cancer ,

Pfizer's Lorbrena breaks into front-line ALK lung cancer, jostling with Novartis, Roche and Takeda

Mar 4, 2021 10:54am
The FDA has expanded Pfizer s Lorbrena approval to include front-line ALK-positive non-small cell lung cancer.
Pfizer’s Lorbrena has finally broken into front-line non-small cell lung cancer, where Novartis, Roche and Takeda are already jockeying for a niche market.
The FDA expanded Lorbrena’s use into newly diagnosed patients with ALK-positive NSCLC, Pfizer said Wednesday. With that front-line nod, the agency converted Lorbrena s conditional green light for previously treated cases into a full approval.
How does Pfizer expect to compete in such a crowded field? As a third-generation ALK inhibitor, Lorbrena has arguably the best efficacy data in head-to-head tests against its predecessor, Xalkori. ....

Novarti Zykadia , Takeda Alunbrig , Roche Alecensa , Uncover Rare Disease Insights , Accelerate Commercialization , Improve Patient , Project Orbis , Alk Inhibitors , Non Small Cell Lung Cancer , விரைவுபடுத்து வணிகமயமாக்கல் , மேம்படுத்த நோயாளி , ப்ராஜெக்ட் ஆர்‌பிஸ் , அல்லாத சிறிய செல் நுரையீரல் புற்றுநோய் ,