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New drug target makes superbugs choke on their own toxic molecules Researchers have uncovered a new mechanism for killing antibiotic-resistant gram-negative bacteria such as E. coli 2/3 An illustration of cardiolipin (red) at work in a bacterial cell, helping the transport machinery move lipopolysaccharide (blue) to the outer membrane Ali Ennis 3/3 From left: Martin Douglass, Alexandria Purcell and Professor Stephen Trent, in a University of Georgia lab in 2019 Andrew Davis Tucker/UGA Antibiotic-resistant bacteria, or “superbugs,” pose one of the most dangerous looming threats to public health. Now, researchers at the University of Georgia have found a new potential weakness in some of the worst strains, which could make them choke on their own toxic molecules. ....
Researchers find target to fight antibiotic resistance 3 days ago Significance of molecule in bacteria was previously unknown Gram-negative bacteria are the bane of health care workers’ existence. They’re one of the most dangerous organisms to become infected with and one of the hardest to treat. But new research from the University of Georgia suggests a component of bacteria’s cell walls may hold the key to crushing the antibiotic-resistant microbes. The reason Gram-negative bacteria are difficult to kill is their double cell membranes, which create an almost impenetrable shield of protection. This shield blocks antibiotics from entering, preventing medications from doing their job of destroying the bacteria. Meanwhile, toxic molecules, known as lipopolysaccharides, on the surface of the bacteria’s outer membrane provoke a potentially deadly immune response. ....
Gram-negative bacteria are the bane of health care workersâ existence. Theyâre one of the most dangerous organisms to become infected withâand one of the hardest to treat. But new research from the University of Georgia suggests a component of bacteriaâs cell walls may hold the key to crushing the antibiotic-resistant microbes. The reason Gram-negative bacteria are difficult to kill is their double cell membranes, which create an almost impenetrable shield of protection. This shield blocks antibiotics from entering, preventing medications from doing their job of destroying the bacteria. Meanwhile, toxic molecules, known as lipopolysaccharides, on the surface of the bacteriaâs outer membrane provoke a potentially deadly immune response. ....