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Type-I interferon stops immune system 'going rogue' during viral infections

Type-I interferon stops immune system 'going rogue' during viral infections
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Ali Ashkar , Amanda Lee , Emily Feng , Mcmaster University , Canadian Institutes Of Health Research , Canadian Institutes ,

McMaster scientists discover trained immune cells are highly effective against cancer


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Credit: McMaster University
Hamilton, ON (April 14, 2021) - Modified immune cells that ruthlessly kill cancerous tumours may prove a game-changer for people living with late-stage cancer.
McMaster University researchers Ali Ashkar and Sophie Poznanski have uncovered that changing the metabolism of natural killer (NK) immune cells allows these cells to overcome the hostile conditions found inside tumours and destroy advanced ovarian and lung cancer.
In the past decade cancer immunotherapy has achieved tremendous therapeutic effects in patient with blood cancers. However, the immunosuppressive conditions found inside solid tumours, whose aggressive growth starves surrounding healthy tissues of energy, have until now remained a formidable barrier for immune cell therapies. ....

Sophie Poznanski , Ali Ashkar , Hal Hirte , Veronica Mcguire , Mcmaster University , Cancer Centre Foundation , Canada Research , Canadian Institutes For Health Research , Faculty Of Health Sciences , Hamilton Health Sciences , Master University , Mcmaster Phd , Cell Metabolism , Canada Research Chair , Natural Immunity , Hamilton Health , Canadian Institutes , Health Research , Juravinski Hospital , Cancer Centre , Health Sciences , அலி அஷ்கர் , வெரோனிகா மக்வைர் , மக்மாஸ்டர் பல்கலைக்கழகம் , புற்றுநோய் மையம் அடித்தளம் , கனடா ஆராய்ச்சி ,