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protection against severe disease, significant is the word that dr. alex seigel, the researcher in south africa, that s the word he use wednesday me when i spoke used with me when i spoke to him. he thinks that two doses will give significant protection against severe disease. but it s very clear from the pfizer data that the third dose may give more robust protection. so i think what this has a lot of people asking is, well, is this basically a three-dose vaccine? is this a vaccine like many other vaccines that ought to be given in three doses? so our colleague, kate bolduan, had a discussion about this earlier with dr. anthony fauci. i don t see that changing tomorrow or next week. but certainly if you want to talk about what optimal protection is, i don t think anybody would argue that optimal protection is going to be with the third shot. whether or not it officially gets changed in the definition, i think that s going to be considered literally on a daily basis. that s always