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EGR1 protein acts as a master regulator of inflammation in macrophages, study suggests


EGR1 protein acts as a master regulator of inflammation in macrophages, study suggests
Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. As part of their function to protect the body against pathogens, macrophages play a major role in initiation, maintenance, and resolution of inflammation. The discovery expands the understanding of how macrophages are set off and deactivated in the inflammatory process, which is critical in many normal and pathological conditions. These findings were published online in the journal ....

Avery Zucco , Alessandro Gardini , Emily Henderson , Gene Expression Regulation Program , Wistar Institute , Early Growth Response , Assistant Professor , Gene Expression , Regulation Program , Cell Development , Immune Response , Progenitor Cells , Transcription Factors , காவேரி ஜுக்கோ , எமிலி ஹென்டர்சன் , கீந் வெளிப்பாடு ஒழுங்குமுறை ப்ரோக்ர்யாம் , ஆரம்ப வளர்ச்சி பதில் , உதவியாளர் ப்ரொஃபெஸர் , கீந் வெளிப்பாடு , ஒழுங்குமுறை ப்ரோக்ர்யாம் , செல் வளர்ச்சி , நோய் எதிர்ப்பு சக்தி பதில் , படியெடுத்தல் காரணிகள் ,