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The microbial species alive today represent only a tiny fraction of the vast diversity of microbes that have inhabited Earth over the past 3 billion years

Upper paleolithicPleistocene epochMicrobial natural productsAncient microbesBiosynthetic gene clustersE novo assemblySynthetic biologyAntibiotic discoveryDrug developmentMicrobial evolutionRchaeological samplesAncient dnaTooth tartarPleistocene epochHolocene epochClimate change