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Novel Oral Medication Reduces Risk of Death by 76% in Patients With ALK-Positive Lung Cancer

The statistically significant and clinically meaningful improvement in disease-free survival is “practice-changing” and may represent a “paradigm shift” in treatment, according to experts.
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Levi Garraway , Alectinib Alecensa , Peter Maccallum Cancer Centre , Benjamin Solomon ,

Cancer drug alectinib less effective when taken with low-fat yogurt

Alectinib appeared less effective among patients with lung cancer when taken with low-fat yogurt compared with a fuller breakfast or lunch, according to data published in Journal of the National Comprehensive Cancer Network.The study assessed absorption rates of the agent among patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer when taken with different types and ....

Zuid Holland , Alectinib Alecensa , Journal Of The National Comprehensive Cancer Network , Erasmus University Medical Center , National Comprehensive Cancer ,

Gregory Masters, MD, on Treating NSCLC With Driver Mutations


This article is a collaboration between MedPage Today and:
A year ago, ASCO released a clinical practice guideline on systemic therapy for patients with stage IV non-small cell lung cancer (NSCLC) without driver alterations. Part two has now been released, and it focuses on patients with stage IV NSCLC with driver alterations.
The guideline is a result of potentially practice-changing evidence published since the last update [in 2017], noted Gregory Masters, MD, of the ChristianaCare Helen F. Graham Cancer Center and Research Institute in Newark, Delaware, and colleagues.
The updated guideline offers 41 recommendations, including the following:
Patients should be offered targeted therapies against ....

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