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High-dose buprenorphine in EDs may improve patient outcomes

By Susan Gonzalez July 15, 2021 Share this with FacebookShare this with TwitterShare this with LinkedInShare this with EmailPrint this (© stock.adobe.com) The administration of high-dose buprenorphine therapy in hospital emergency departments (ED) may safely and rapidly diminish withdrawal symptoms and sustain craving suppression in people with opioid use disorder, improving their likelihood of accessing follow-up treatment, according to a study co-authored by Yale’s Gail D’Onofrio. Buprenorphine is a medication approved by the U.S. Food and Drug Administration to treat opioid use disorder. Giving lower doses of the medication is the current standard of care. The study found, however, that giving higher doses of buprenorphine in EDs may provide a longer period of relief to people after they are discharged, which may help them navigate barriers to access to follow-up care before they experience withdrawal symptoms.

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Yale researchers size up the mental health toll of the pandemic

By Brita Belli April 12, 2021 Share this with FacebookShare this with TwitterShare this with LinkedInShare this with EmailPrint this (Illustration by Michael S. Helfenbein) For all the attention paid to the short and long-term physical effects of COVID-19, the disease has serious mental health consequences, too.  In a new report, Yale researchers examine how the pandemic is affecting our brains in particular the prefrontal cortex, the part of the brain that is involved in decision making, impulse control, and emotional regulation. For 44 to 66 million disadvantaged Americans, the researchers say, the pandemic is exacerbating existing stressors including financial insecurity and systemic racism which impairs prefrontal cortical performance that is critical for regulating emotions and coping, among other functions. 

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Altered calcium signaling is linked to early-stage Alzheimer's pathology

Altered calcium signaling is linked to early-stage Alzheimer's pathology
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Leaking calcium in neurons an early sign of Alzheimer's pathology

 E-Mail New Haven, Conn. Alzheimer s disease is known for its slow attack on neurons crucial to memory and cognition. But why are these particular neurons in aging brains so susceptible to the disease s ravages, while others remain resilient? A new study led by researchers at the Yale School of Medicine has found that susceptible neurons in the prefrontal cortex develop a leak in calcium storage with advancing age, they report April 8 in the journal Alzheimer s & Dementia, The Journal of the Alzheimer s Association. This disruption of calcium storage in turns leads to accumulation of phosphorylated, or modified, tau proteins which cause the neurofibrillary tangles in the brain that are a hallmark of Alzheimer s.

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