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Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5. ....

United States , Florian Plattner , Sarbjit Singh , Ayanabha Chakraborti , James Bibb , Emily Henderson , Yogesh Sonawane , Jayapal Reddy Mallareddy , Edwardp Acosta , Alan Umfress , Amarnath Natarajan , Kevinj Ryan , Research Strategies , University Of Nebraska Medical Center , Department Of Pharmacology , Birmingham Department , Medicine Department , Neuro Research Strategies , Nebraska Medical Center , Lzheimer 39s Disease , Head Trauma , Arkinson 39s Disease ,

Drug Compound Targets Signaling Regulator and Reduces Anxiety-Like Behavior in Mice

Researchers have developed a brain-permeable compound (25-106) that targets a signaling regulator in brain neurons. The team notes that when the new compound was administered to mice, it could alter their neurobehavior and reduce anxiety-like behavior. ....

United States , Florian Plattner , Sarbjit Singh , Ayanabha Chakraborti , James Bibb , Yogesh Sonawane , Jayapal Reddy Mallareddy , Edwardp Acosta , Alan Umfress , Amarnath Natarajan , Kevinj Ryan , University Of Alabama At Birminghamdepartment Surgery , Research Strategies , University Of Nebraska Medical Center , Department Of Pharmacology , Medicine Department , Neuro Research Strategies , Nebraska Medical Center ,

Novel preclinical drug could have potential to combat depression, brain injury and cognitive disorders

Novel preclinical drug could have potential to combat depression, brain injury and cognitive disorders
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United States , Florian Plattner , Sarbjit Singh , Ayanabha Chakraborti , James Bibb , Yogesh Sonawane , Jayapal Reddy Mallareddy , Edwardp Acosta , Alan Umfress , Amarnath Natarajan , Kevinj Ryan , University Of Alabama At Birminghamdepartment Surgery , Research Strategies , University Of Nebraska Medical Center , National Institutes Of Health , Department Of Pharmacology , Oneal Comprehensive Cancer Center , Medicine Department , Neuro Research Strategies , Nebraska Medical Center , National Institutes , Champ Lyons Endowed Chair , General Surgery , O Neal Comprehensive Cancer ,