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Membranes unlock potential to vastly increase cell-free vaccine production


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Membranes unlock potential to vastly increase cell-free vaccine production
By cracking open a cellular membrane, Northwestern University synthetic biologists have discovered a new way to increase production yields of protein-based vaccines by five-fold, significantly broadening access to potentially lifesaving medicines.
In February, the researchers introduced a new biomanufacturing platform that can quickly make shelf-stable vaccines at the point of care, ensuring they will not go to waste due to errors in transportation or storage. In its new study, the team discovered that enriching cell-free extracts with cellular membranes – the components needed to made conjugate vaccines – vastly increased yields of its freeze-dried platform. ....

Neha Kamat , Michael Jewett , Jasmine Hershewe , Katherine Warfel , Nature Communications , Lucile Packard Foundation , Scholar Program , Melinda Gates Foundation , National Science Foundation , Northwestern Mccormick School Of Engineering , Northwestern Center , Research Laboratory Center , Northwestern University , Defense Threat Reduction Agency , Mccormick School , Air Force Research Laboratory Center , Camille Dreyfus Teacher Scholar , National Science Foundation , Nature Communications , Air Force , Synthetic Biology , Pandemic Response , Immune Response , Cell Membrane , Supply Chain , நேஹா காமத் ,