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"Lidocaine for Neuropathic Cancer Pain (LiCPain): study protocol for a " by Jessica Lee, David Currow et al.

Introduction Many patients experience unrelieved neuropathic cancer-related pain. Most current analgesic therapies have psychoactive side effects, lack efficacy data for this indication and have potential medication-related harms. The local anaesthetic lidocaine (lignocaine) has the potential to help manage neuropathic cancer-related pain when administered as an extended, continuous subcutaneous infusion. Data support lidocaine as a promising, safe agent in this setting, warranting further evaluation in robust, randomised controlled trials. This protocol describes the design of a pilot study to evaluate this intervention and explains the pharmacokinetic, efficacy and adverse effects evidence informing the design. Methods and analysis A mixed-methods pilot study will determine the feasibility of an international first, definitive phase III trial to evaluate the efficacy and safety of an extended continuous subcutaneous infusion of lidocaine for neuropathic cancer-related pain. This stud ....

New South Wales , University Of Technology Sydney , Patient Information , Consent Form , Sydney Local Health District , Human Research Ethics Committee , Technology Sydney , Adult Palliative Care , Cancer Pain , Clinical Trials , Pain Management ,

gov.ie - Minister Donnelly establishes Steering Group to develop a new Palliative Care Policy for Adults

gov.ie - Minister Donnelly establishes Steering Group to develop a new Palliative Care Policy for Adults
gov.ie - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from gov.ie Daily Mail and Mail on Sunday newspapers.

Maurice Dillon , Michelle Quinn , Margaret Mcmahon , Karen Ryan , Fintan Fagan , Sarah Treleaven , Feargal Twomey , Sharon Foley , Paul Rowe , Bridget Johnston , Marian Omahony , Brendan Oshea , Brendan Kennelly , Karen Charnley , Terry Hanan , Mary Flanagan , Clinical Care Program For Palliative , National Clinical Lead For Palliative Care , Trinity College Dublin , National Advisory Committee On Palliative Care , Ireland Institute Of Hospice , Department Of Health , Clinical Professor At University College Dublin , International Evidence , Cancer Control Programme , Irish Hospice Foundation ,

"Phase III, international, multicentre, double-blind, dose increment, p" by Hiromichi Matsuoka, Katherine Clark et al.

Introduction Management of neuropathic cancer pain (NCP) refractory to regular opioids remains an important challenge. The efficacy of pregabalin for NCP except chemotherapy-induced peripheral neuropathy (CIPN) has already been confirmed in two randomised controlled trials (RCTs) compared with placebo. Duloxetine offers the potential of analgesia in opioid refractory NCP. However, there are no RCT of duloxetine for the management of opioid-refractory NCP as a first line treatment. Both classes of drugs have the potential to reduce NCP, but there has been no head-to-head comparison for the efficacy and safety, especially given differing side effect profiles. Methods and analysis An international, multicentre, double-blind, dose increment, parallel-arm, RCT is planned. Inclusion criteria include: adults with cancer experiencing NCP refractory to opioids; Brief Pain Inventory (BPI)-item 3 (worst pain) of ≥4; Neuropathic Pain on the Leeds Assessment of Neuropathic Symptoms and Signs Pain ....

New South Wales , Osaka City University Hospital Certified Review Board , Brief Pain Inventory , Neuropathic Pain , Leeds Assessment , Neuropathic Symptoms , Signs Pain Scale , Adult Palliative Care , Cancer Pain , Clinical Trials ,

"Occurrence and timely management of problems requiring prompt interven" by John A. Woods, Judith M. Katzenellenbogen et al.

Abstract
Objectives Anticipation and prompt relief of symptoms among patients with a life-limiting illness is a core element of palliative care. Indigenous Australians commonly encounter cultural barriers in healthcare that may impair outcomes. The Palliative Care Outcomes Collaboration collects patient care data for the purposes of continuous quality improvement and benchmarking, with each recorded care episode divided into phases that reflect a patient s condition. We aimed to investigate differences between Indigenous and non-Indigenous patients in the occurrence and duration of â € unstable phases (which indicate unanticipated deterioration in a patient s condition or circumstances), and determine attainment of the relevant benchmark (resolution of unstable phases in ≤3 days in 90% of cases) for both groups. Design Cohort study. Setting Australia-wide hospital-based and community-based specialist palliative care (1 January 2010 to 30 June 2015). Participants 139 556 ....

Palliative Care Outcomes Collaboration , Conclusions Despite , Indigenous Australians , Adult Palliative Care , Public Health , Quality In Health Care , நோய்த்தடுப்பு பராமரிப்பு ஔட்கம்ஸ் இணைந்து , உள்நாட்டு ஆஸ்திரேலியர்கள் ,