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Generative AI revolutionizes antibiotic development against resistant pathogens

With nearly 5 million deaths linked to antibiotic resistance globally every year, new ways to combat resistant bacterial strains are urgently needed. ....

Kyle Swanson , Chan Zuckerberg Biohub , James Zou , David Braley Centre For Antibiotic Discovery , Canadian Institutes Of Health Research , Weston Family Foundation , Mcmaster University , Stanford Medicine , Nature Machine , David Braley Centre , Antibiotic Discovery , Canadian Institutes , Health Research , Acinetobacter Baumannii , Antibiotic Resistance , Artificial Intelligence , Drug Discovery , Public Health ,

Advanced sequencing reveals eye microbiome variances linked to dry eye

Researchers have used advanced sequencing technology to determine how the mix of microbes present in patients with healthy eyes differs from the mix found in patients with dry eye. ....

United States , San Antonio , Pallavi Sharma , Van Kley , Alexandra Van Kley , American Society For Biochemistry , Stephenf Austin State University In Nacogdoches , State University , American Society , Molecular Biology , Dry Eye , Molecular Biology ,

New antibiotic kills deadly, drug-resistant bacteria in 'scientific breakthrough'

Scientists in Switzerland have announced the discovery of a new class of antibiotics that have shown to be effective against a deadly, drug-resistant bacteria. ....

Michael Lobritz , Kenneth Bradley , Jim Oneill , Marc Siegel , Centers For Disease , Roche Pharma Research Early Development , Infections Program , Langone Medical Center , Disease Control , Roche Pharma Research , Early Development , Fox News Digital , Fox News , Jimo Neill , Medical Center , Emerging Infections , Harmful Bacteria , Acinetobacter Baumannii , Kenneth Bradley , Gram Negative Bacteria , Drug Resistant Bacteria , Fox News , Outer Membrane ,

Experimental antibiotic kills deadly superbug, opens whole new class of drugs

The relatively large molecule clogs a transport system, leading to lethal toxicity. ....

Morgan Gugger , Michael Lobritz , Paul Hergenrother , World Health Organization , Harvard University , University Of Illinois At Urbana Champaign , Drug Administration , Scanning Electron Microscope , Kenneth Bradley ,

New compound effective against bacterial species resistant to multiple classes of existing antibiotics

Recent studies by Zampaloni et al. and Pahil et al. published in the journal Nature describe a novel method of inhibiting the growth of Gram-negative bacteria such as Acinetobacter using antibiotics consisting of macrocyclic peptides that target the bacterial protein bridge machinery that transports lipopolysaccharides from the cytoplasm to the outer membrane. ....

Acinetobacter Baumannii , Antibiotic Resistance , Cell Membrane , Global Health , N Vitro , N Vivo ,