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Mining Old Drugs for New COVID Tricks

Early in the pandemic, researchers began exploring various avenues to repurposing drugs for COVID-19.
There are many paths to repurposing, including high-throughput drug screening, which uses automated methods to screen thousands or even millions of molecules for targeted biological activity in a disease of interest. Other approaches include focusing on a certain biological mechanism of action (like testing other antivirals in COVID); combing through clinical trial data and public records; or, in the case of sildenafil citrate (Viagra), incidental clinical observation. (See
MedPage Today s full story on how drug repurposing is gaining momentum as demand for a COVID pill grows.) ....

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Drug Repurposing for COVID-19: What Went Wrong?

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So far in the pandemic, support for research on drug repurposing particularly for inexpensive generics has not played a huge role in finding new treatments for COVID-19, but that appears to be changing.
Critics charge that drug repurposing is like looking for a needle in a haystack. It does not always work, and can raise false hopes and waste resources. In a March 7 interview with
60 Minutes, for instance, NIH director Francis Collins, MD, PhD, said drug repurposing is only going to work if you re kind of lucky, because you re basically picking things that were developed for a different disease. ....

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