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In CLL, BTK-Inhibitor Resistance Remains a Confounding Problem

Investigators say attempts to overcome mutational resistance to Bruton’s tyrosine kinase (BTK) inhibitors have had mixed results among patients who have chronic lymphocytic leukemia (CLL). ....

Eli Lilly , Abbvie Genentech , Pharmacyclics Janssen , Chronic Lymphocytic Leukemia , Btk Inhibitor , Noncovalent Btk Inhibitors , C481 Mutations , Mutational Resistance ,