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Is vaccine response to SARS-CoV-2 preserved after switching to anti-CD20 therapies in patients with multiple sclerosis or related disorders?

Background Although vaccination against SARS-CoV-2 is recommended prior to introducing anti-CD20 therapies, limited data are available regarding the evolution of post-vaccinal immunity.

Methods This retrospective study compared anti-Spike antibody titres at 6 and 12 months from SARS-CoV-2 vaccination between patients vaccinated before switching to anti-CD20 (‘Switch’) and two control groups: (1) patients vaccinated under disease-modifying therapies (DMTs) other than fingolimod and anti-CD20 (‘Other DMTs’); (2) patients vaccinated on anti-CD20 (‘Anti-CD20’). Anti-Spike-specific T-cell responses were compared between ‘Switch’ and ‘Anti-CD20’ groups.

Results Fifty-three patients were included in the ‘Switch’ group, 54 in the ‘Other DMTs’ group and 141 in the ‘Anti-CD20’ group. At 6 months, in the subset of patients who received a booster dose, the ‘Switch’ group had lower anti-Spike titres compared with the ‘Other DMTs’ group (median 2 ....

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