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Olaparib Monotherapy Showcases Antitumor Activity in BAP1-mutated RCC

Olaparib monotherapy elicited responses with favorable tolerability in patients with renal cell carcinoma whose tumors harbored BAP1 or other DNA repair gene mutations, according to data from the interim analysis of the phase 2 ORCHID trial presented during the 2023 Kidney Cancer Research Summit. ....

Yasser Mohamed Ali , Olaparib Lynparza , Kidney Cancer Research Program , Database Consortium , International Metastatic , Kidney Cancer Research Summit , Cancer Research , Yasser Mohamed Ali Ged , Johns Hopkins , Genitourinary Cancer , Bap1 Mutated Rcc , Renal Cell Carcinoma , Phase 2 Orchid Trial , 2023 Kidney Cancer Research Summit ,

Frontline Lenvatinib Plus Pembrolizumab Produces Superior Responses Vs Sunitinib in Advanced RCC

Lenvatinib plus pembrolizumab demonstrated improved overall response rates compared with sunitinib monotherapy in treatment-naïve patients with advanced renal cell carcinoma regardless of risk status or PD-L1 expression. ....

United States , Lenvatinib Lenvima , International Metastatic , Kidney Cancer Research Summit , Database Consortium , Memorial Sloan Kettering Cancer Center , Cancer Research , Western Europe , North America , Robertj Motzer , Lenvatinib Pembrolizumab , Phase 3 Clear Study Nct02811861 , Renal Cell Carcinoma , 2023 Kidney Cancer Research Summit ,