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Sunburn — The morning read of what's hot in Florida politics — 7.22.21

Sunburn — The morning read of what's hot in Florida politics — 7.22.21
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Respiratory syncytial virus induces β2-adrenergic receptor dysfunction in human airway smooth muscle cells

Agonists of the β2-adrenergic receptor (β2AR) are used as bronchodilators to relieve airway obstruction in patients with asthma. However, these drugs are much less effective in patients with airway obstruction caused by infection with respiratory syncytial virus (RSV). Harford et al . found that infection of human airway smooth muscle cells with RSV resulted in phosphorylation of the β2AR, its loss from the plasma membrane, and its proteasomal cleavage. Furthermore, RSV infection resulted in increased Ca2+ signaling in these cells, promoting their contractility in vitro. These results suggest that dysregulation of the location, abundance, and function of the β2AR by RSV may underlie the ineffectiveness of β2AR agonists in relieving airway obstruction in infected patients.

Pharmacologic agonism of the β2-adrenergic receptor (β2AR) induces bronchodilation by activating the enzyme adenylyl cyclase to generate cyclic adenosine monophosphate (cAMP). β2AR agonists are generall ....

United States , Department Of Cardiovascular , Metabolic Sciences , Lerner Research Institute , Cleveland Clinic Foundation , ஒன்றுபட்டது மாநிலங்களில் , துறை ஆஃப் இருதய , வளர்சிதை மாற்ற அறிவியல் , லெர்னர் ஆராய்ச்சி நிறுவனம் , கிளீவ்லேண்ட் சிகிச்சையகம் அடித்தளம் ,