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When paired with lifestyle management, once-weekly semaglutide (Ozempic) yielded significant weight loss for overweight adults with type 2 diabetes, the manufacturer-sponsored Semaglutide Treatment Effect in People with Obesity (STEP) 2 study found.
In the superiority phase III trial of over 1,200 adults with a body mass index (BMI) of at least 27, those on 2.4 mg of weekly subcutaneous semaglutide lost an average of 9.6% of baseline body weight after 68 weeks of treatment versus 3.4% for those on placebo and lifestyle intervention alone (treatment difference -6.2 percentage points, 95% CI -7.3 to -5.2,
P 0.0001), reported Ildiko Lingvay, MD, of the University of Texas Southwestern Medical Center in Dallas, and colleagues.