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Investegate |Translational Research in Onco Announcements | Translational Research in Onco: TRIO Completes Enrollment of Phase III NATALEE Breast Cancer Clinical Trial

Investegate |Translational Research in Onco Announcements | Translational Research in Onco: TRIO Completes Enrollment of Phase III NATALEE Breast Cancer Clinical Trial
investegate.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from investegate.co.uk Daily Mail and Mail on Sunday newspapers.

United States , Jeff Legos , Launa Aspeslet , Dennisj Slamon , University Of California , Clinical Translational Research , Novartis Institutes For Biomedical Research , Astex Pharmaceuticals , Translational Research In Oncology , Head Of Oncology Drug Development , Los Angeles Jonsson Comprehensive Cancer Center , Cancer Clinical , Research In Oncology , New Adjuvant Trial , Executive Director , Los Angeles Jonsson Comprehensive Cancer , Senior Vice President , Oncology Drug , Novartis Institutes , Biomedical Research , ஒன்றுபட்டது மாநிலங்களில் , ஜெஃப் லெகோஸ் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , மருத்துவ மொழிபெயர்ப்பு ஆராய்ச்சி , நோவர்த்திச் நிறுவனங்கள் க்கு உயிர் மருத்துவ ஆராய்ச்சி , மொழிபெயர்ப்பு ஆராய்ச்சி இல் புற்றுநோயியல் ,

Pharma Looks to Inflammasome Inhibitors as All-Around Therapies

Heart failure, gout, COVID-19, melanoma
Completed Phase 1 and Phase 1b in patients with heart failure and Phase 2a in patients with acute gout flares. A Phase 2 trial for people with moderate COVID-19 symptoms is ongoing, and the company is planning a Phase 2 trial in late-stage melanoma, along with an approved immunotherapy.
Drugging the inflammasome
For years after the inflammasome’s initial discovery, the search for drugs that target it yielded no promising leads, Cooper says. “Big pharma all went and screened their libraries of drugs and said, can we find an inhibitor? But no one could.”
Several years ago, that began to change. Luke O’Neill, an immunologist at Trinity College Dublin, was one of the people searching for an NLRP3 inhibitor, with colleagues at his company Opsona. He knew that a scientist named Chris Gabel had been working at Pfizer in the late 1990s on a molecule called CRID3, which appeared to block IL-1β production. O’Neill was int ....

New York , United States , United Kingdom , University College , New South Wales , City Of , Damaris Skouras , Guido Junge , Matt Cooper , Charles Dinarello , Philip Hawkins , Fabio Martinon , Michael Mcdermott , Chris Gabel , Kate Schroder , Luke Oneill , Royal London School Of Medicine , Institutes For Biomedical Research , Novartis Institutes For Biomedical Research , University Of Queensland , Trinity College Dublin , Drug Administration , University Of Colorado School Medicine , University College Medical School , University Of Leeds , University Of Lausanne ,

Broad Institute launches the Eric and Wendy Schmidt Center to connect biology, machine learning for understanding programs of life

Broad Institute launches the Eric and Wendy Schmidt Center to connect biology, machine learning for understanding programs of life
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Briefs on local businesspeople, including Paul Brassil, Robyn Nasuti, Sean Terrell, Kevin Haley and Dana Drissel

Paul Brassil of
Medfield has joined the company as senior vice president/chief information officer and will oversee PCU’s information technology and digital innovation efforts.
Brassil has more than 25 years of experience in the information technology leadership field with entities such as Commonwealth Medicine (a division of UMass Medical School), the Federal Reserve Bank of Boston, EMC Corp. and Siemens IT Solutions and Services Inc.
He holds an MS in computer information systems from Bentley University in
Waltham and a BA in Business Administration from Bridgewater State University.
Brassil s community involvement spans initiatives focused on workforce development and industry leadership serving as a member of the Tech Hire Advisory Group of Boston’s Private Industry Council (comprised of Boston CIOs developing summer intern programs for low/moderate income students in the Boston Public Schools); an adviser for Fintech Women (helping women in banking ....

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Future Founders Initiative aims to increase female entrepreneurship in biotech

Caption:
The Future Founders Initiative aims to increase the fraction of MIT female faculty who found companies from less than 10 percent to 25 percent by 2024.
Caption:
Future Founders collaborators (clockwise from top left) Susan Hockfield, MIT president emerita; Harvey Lodish, professor of biology and biomedical engineering; and Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science.
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The gender disparity in biotech really got Sangeeta Bhatia’s attention while she was on sabbatical. Bhatia had taken a year to focus on her startup biotech company, Glympse Bio. The startup, inspired by bioengineering breakthroughs in Bhatia’s lab at MIT, advances biosensing technology and is now well-funded. But in 2018, Bhatia had to do what all startup founders have to do pitch ideas and court ....

Harvard University , United States , Jodi Cook , Susan Hockfield , Glympse Bio , Ron Bartek , Theresia Gouw , Jackie Grant , Peter Barrett , Angela Koehler , Amy Schulman , Carolyn Bertozzi , Tanja Konig , Maria Zuber , Anantha Chandrakesan , Jay Bradner , Anantha Chandrakasan , Harvey Lodish , Daphne Koller , Sangeeta Bhatia , Russ Wilcox , Kronos Bio , Nancy Hopkins , Aoife Brennan , Simmons University Business School , Institute For Medical Engineering ,