In the study published in the journal Integrative Physiology, the researchers found that a high intake of polyphenols may have a protective effect on patients with COVID-19 and prevent disease progression.
High intake of a micronutrient can protect from Covid-19 - The Hindu BusinessLine thehindubusinessline.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thehindubusinessline.com Daily Mail and Mail on Sunday newspapers.
Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages
Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defenses: these become, thus, the tumor-associated macrophages (TAMs).
An article published in the journal
Cancer Research describes a new molecular mechanism that counteracts the immunosupressive action of these macrophages to boost tumor growth, and brings knowledge of potential interest for the design of future therapeutical options against cancer. The preclinical study is led by the tenure-track 2 lecturer Annabel Valledor, from the Faculty of Biology and the Institute of Biomedicine of the University of Barcelona (IBUB).
Credit: IRB Barcelona
T-cell acute lymphoblastic leukaemia (T-ALL) is a cancer of the blood that affects mainly children, but also less frequently adults. In adults, although the response to treatment might be initially positive, relapses are common and have a poor prognosis.
A collaborative project between IRB Barcelona s Biomedical Genomics lab, headed by ICREA researcher Núria López-Bigas, Anna Bigas group at the Hospital del Mar Medical Research Institute (IMIM-Hospital del Mar), and Josep Maria Ribera s lab at the Josep Carreras Leukaemia Research Institute (IJC) has discovered that the cells responsible for resistance to T-ALL treatment in adults are already present in the tumours before diagnosis.
Researchers discover cells responsible for resistance to T-ALL treatment
T-cell acute lymphoblastic leukemia (T-ALL) is a cancer of the blood that affects mainly children, but also less frequently adults. In adults, although the response to treatment might be initially positive, relapses are common and have a poor prognosis.
A collaborative project between IRB Barcelona s Biomedical Genomics lab, headed by ICREA researcher Núria López-Bigas, Anna Bigas group at the Hospital del Mar Medical Research Institute (IMIM-Hospital del Mar), and Josep Maria Ribera s lab at the Josep Carreras Leukaemia Research Institute (IJC) has discovered that the cells responsible for resistance to T-ALL treatment in adults are already present in the tumors before diagnosis.