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UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth

Significance Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is one of the most deadly cancer types, with a 5-y survival rate below 10%. One reason for this high mortality rate is that PDAC cells have an enhanced ability to survive and proliferate despite existing in nutrient-deprived environments. Understanding the metabolic rewiring that enables nutrient scavenging and rapid metabolic processing of PDAC cells can provide new strategies to develop effective treatment options for this intractable disease. In this study, convergent findings reveal that UGP2 has a central role in the growth and metabolism of PDAC cells through the regulation of glycogen synthesis and protein N-glycosylation, highlighting therapeutic possibilities for this deadly cancer.

Developer deep dive: Designing proteins and reagents for cell and gene therapy research on SelectScience

23 Aug 2021 Recombinant proteins require strict quality control, as quality issues affect the reliability of the intended downstream application. Cell and gene therapy research in particular demands a higher quality of protein that adheres to strict quality control and has comprehensive validation. In this exclusive SelectScience ® webinar, Dr. Deborah Moore-Lai, Director of Protein Development at Abcam, will introduce a new range of premium bioactive proteins. During the session, Moore-Lai will be detailing Abcam’s manufacturing workflow, as well as outlining the company’s mission to support scientists in achieving their goals in cell and gene therapy research and other research areas.

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