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How night shift work increases cancer risk revealed in new study -- Health & Wellness -- Sott.net


© Bala Koritala
A night shift schedule is associated with increased DNA damage and misalignment of the DNA repair mechanism, providing a possible explanation for the elevated risk of cancer in night shift workers.New clues as to why night shift workers are at increased risk of developing certain types of cancer are presented in a new study conducted at Washington State University Health Sciences Spokane.
Published online in the
Journal of Pineal Research, the study involved a controlled laboratory experiment that used healthy volunteers who were on simulated night shift or day shift schedules. Findings from the study suggest that night shifts disrupt natural 24-hour rhythms in the activity of certain cancer-related genes, making night shift workers more vulnerable to damage to their DNA while at the same time causing the body s DNA repair mechanisms to be mistimed to deal with that damage. ....

Hugh Mitchell , Van Dongen , Jason Mcdermott , Bala Sc Koritala , Kenneth Porter , Hans Van Dongen , Justin Teeguarden , Rajendra Gajula , Mugimane Manjanatha , Osama Arshad , Bala Koritala , Tarana Arman , Shobhan Gaddameedhi , Performance Research Center , Elsons Floyd College Of Medicine , Pacific Northwest National Laboratory Biological Sciences Division , Carolina State University Biological Sciences Department , Journal Of Pineal Research , Human Health , Washington State University Health Sciences Spokane , College Of Pharmacy , Health Sciences Spokane , Washington State University Health Sciences , Pineal Research , World Health Organization , International Agency ,

Research offers insights on how night shift work increases cancer risk


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IMAGE: A night shift schedule is associated with increased DNA damage and misalignment of the DNA repair mechanism, providing a possible explanation for the elevated risk of cancer in night shift.
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Credit: Bala Koritala
SPOKANE, Wash. - New clues as to why night shift workers are at increased risk of developing certain types of cancer are presented in a new study conducted at Washington State University Health Sciences Spokane.
Journal of Pineal Research, the study involved a controlled laboratory experiment that used healthy volunteers who were on simulated night shift or day shift schedules. Findings from the study suggest that night shifts disrupt natural 24-hour rhythms in the activity of certain cancer-related genes, making night shift workers more vulnerable to damage to their DNA while at the same time causing the body s DNA repair mechanisms to be mistimed to deal with that damage. ....

Hugh Mitchell , Van Dongen , Jason Mcdermott , Kenneth Porter , Justin Teeguarden , Hans Van Dongen , Mugimane Manjanatha , Rajendra Gajula , Tarana Arman , Osama Arshad , Bala Koritala , Shobhan Gaddameedhi , Performance Research Center , National Institutes Of Health , Pacific Northwest National Laboratory , Research Programs , Elsons Floyd College Of Medicine , Pacific Northwest National Laboratory Biological Sciences Division , Carolina State University Biological Sciences Department , Journal Of Pineal Research , Washington State University Health Sciences Spokane , Human Health , College Of Pharmacy , Health Sciences Spokane , Washington State University Health Sciences , Pineal Research ,

Research offers insights on how night shift work increases cancer risk | WSU Insider


March 8, 2021
Findings from the study suggest that night shift workers are at increased risk of developing cancer because night shifts disrupt natural 24-hour rhythms in the activity of certain cancer-related genes.
By Judith Van Dongen
WSU Health Sciences Spokane Office of Research
SPOKANE, Wash. – New clues as to why night shift workers are at increased risk of developing certain types of cancer are presented in a new study conducted at Washington State University Health Sciences Spokane.
Journal of Pineal Research, the study involved a controlled laboratory experiment that used healthy volunteers who were on simulated night shift or day shift schedules. Findings from the study suggest that night shifts disrupt natural 24-hour rhythms in the activity of certain cancer-related genes, making night shift workers more vulnerable to damage to their DNA while at the same time causing the body’s DNA repair mechanisms to be mistimed to deal with that damage. ....

Hugh Mitchell , Judith Van , Tom Rickey , Van Dongen , Jason Mcdermott , Kenneth Porter , Justin Teeguarden , Hans Van Dongen , Rajendra Gajula , Mugimane Manjanatha , Tarana Arman , Osama Arshad , Bala Koritala , Shobhan Gaddameedhi , Pacific Northwest National Laboratory News Media , Performance Research Center , Elsons Floyd College Of Medicine , Pacific Northwest National Laboratory Biological Sciences Division , Carolina State University Biological Sciences Department , Journal Of Pineal Research , Washington State University Health Sciences Spokane , Human Health , College Of Pharmacy , Health Sciences Spokane Office Of Research , Carolina State University , Health Sciences Spokane ,