Coronavirus s Spike Protein Plays Vital Role in Disease by Angela Mohan on May 5, 2021 at 8:43 AM
Coronavirus s spike proteins play a key role in the illness. The paper, published in the journal
Circulation Research, concluded that COVID-19 is a vascular disease, demonstrating how the virus damages and attacks the vascular system on a cellular level.
The findings help explain COVID-19 s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies. A lot of people think of it as a respiratory disease, but it s really a vascular disease, said Uri Manor, Assistant Research Professor at the Salk Institute in California.
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COVID Spike Protein Alone may Cause Lung Inflammation by Colleen Fleiss on April 28, 2021 at 11:22 PM
Exposure to SARS-CoV-2 spike protein alone was enough to induce coronavirus-like symptoms, including lung damage and severe lung inflammation, said researchers.
The researchers from Old Dominion University, Virginia, US, developed a genetically modified mouse and injected it with a segment of the spike protein and analysed their response 72 hours later. Another group of mice received only saline to serve as control.
The genetically modified mice exhibited Covid-19-like symptoms that included severe inflammation, an influx of white blood cells into their lungs and evidence of a cytokine storm an immune response in which the body starts to attack its own cells and tissues rather than just fighting off the virus. However, the mice that only received saline remained normal, the results showed.
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