Oak Brook, IL - The April edition of
SLAS Discovery is a special issue on advances in protein degradation curated by guest editors M. Paola Castaldi, Ph.D., and Stewart L. Fisher, Ph.D.
Targeted protein degradation has generated interest within the drug discovery arena due to the inhibition of one particular function of a protein not often delivering the successful results that comes from whole-protein depletion. The pharmacology of PROTACs present challenges, however, namely for the development of orally bioavailable drugs. In the article Target Validation Using PROTACs: Applying the Four Pillars Framework authors Rados?aw P. Nowak, Ph.D., and Lyn H. Jones, Ph.D., describe the application of a translational pharmacology framework (the four pillars) to expedite PROTAC development by informing pharmacokinetic-pharmacodynamic (PKPD) understanding and helping clarify structure-activity relationships. Nowak and Jones hope that the four pillars will serve as a useful guideline to th
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The Global Clinical Chemistry Analyzers Market Size is Projected to Reach USD 15.2 Billion by 2026 from USD 12.3 Billion in 2021, at a CAGR of 4.3%
Market growth is driven by factors such as the rising geriatric population and the increasing prevalence of chronic & lifestyle diseases, growing adoption of Point-of-Care testing devices and rising demand for laboratory automation. On the other hand, high capital investment, shortage of clinical laboratory technicians, and the availability of refurbished products is expected to limit market growth to a certain extent in the coming years.
The reagents accounted for the highest growth rate in the clinical chemistry analyzers market, by product, during the forecast period
Oak Brook, IL - The March edition of
SLAS Discovery features the cover article, Therapeutic and Vaccine Options for COVID-19: Status After 6 Months of the Disease Outbreak by Christian Ogaugwu (Federal University Oye-Ekiti, Ekiti State, Nigeria ), Dawid Maciorowski, Subba Rao Durvasula, Ph.D., Ravi Durvasula, M.D., and Adinarayana Kunamneni, Ph.D. (Loyola University Medical Center, Maywood, IL, USA).
This cover article focuses on the therapeutic and vaccine options available against the novel coronavirus, roughly six months after the outbreak; because the COVID-19-related death toll worldwide had reached 500,000 in six months (and ballooned to over 2,000,000 at the time of publishing) the importance of options to temper the disease cannot be overemphasized. The article highlights the available treatment alternatives for mild and serious active cases of COVID-19 infections and explores the vaccine options that should aid to confer immunity to vaccinated individuals. In addition
The Society for Laboratory Automation and Screening (SLAS) is pleased to announce David McIntyre, Ph.D. candidate from Boston University (Boston, MA, USA), as the 2021 SLAS Graduate Education Fellowship Grant recipient.