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New holy grail HIV vaccine shows huge promise after first human trials
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Novel HIV vaccine approach shows promise in Phase-1 clinical trials
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Results from a phase 1 clinical trial suggest the vaccine can induce the targeted immune response. By
Story at a glance
Researchers gave participants the vaccine or a placebo in a phase 1 clinical trial of the HIV vaccine candidate.
Participants were able to produce the targeted antibodies in response to the vaccine.
This vaccine could be the first stage in a multi-step vaccine regimen for HIV.
Human immunodeficiency virus (HIV) is a virus that attacks the body’s immune system. Over time, this can lead to Acquired Immunodeficiency Syndrome, or AIDS. Advances in treatment of HIV using antiviral drugs has been successful in recent years, but producing a vaccine has been elusive. Scientists at the International AIDS Vaccine Initiative (IAVI) and Scripps Research have been working on an approach that is proving to be fruitful so far.
A novel vaccine approach for the prevention of HIV has shown promise in Phase I trials.
IAVI and Scripps research reported that the vaccine which is being developed to act as an immune primer, to trigger the activation of naïve B cells via a process called germline-targeting, as the first stage in a multi-step vaccine regimen to elicit the production of many different types of broadly neutralizing antibodies (bnAbs), successfully stimulated the production of the rare immune cells needed to generate antibodies against HIV in 97 per cent of participants.
European pharmaceutical review reported that stimulating the production of bnAbs has been pursued as a holy grail in HIV for decades. It is hoped that these specialised blood proteins could attach to HIV surface proteins called spikes, which allow the virus to enter human cells, and disable them via difficult-to-access regions that do not vary much from strain to strain.
We finally have a vaccine that works against HIV (in early tests)
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