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 E-Mail BOSTON - (April 12, 2021) - A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published today by Nature Metabolism, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) a protein known to sense noxious stimuli, including pain and temperature. Specifically, the authors point to smooth muscle cells expressing the Trpv1 receptor and identify them as a novel source of energy-burning brown fat cells (adipocytes). This should translate into increased overall energy expenditure - and ultimately, researchers hope, reduced weight.

United statesUnited kingdomYu hua tsengAnushka guptaMatthewd lynesUniversity of californiaNational institute of diabetesJoslin diabetes centerTian lian huang joslin diabetes centerAmerican diabetes associationUs national institutes of healthLi lun ho massachusetts institute of technologyNature metabolismMary piperPublic healthMassachusetts institute