How many people did Samuel Little kill? Little admitted to killing 93 women, while investigators have linked him to over 60 murders. The FBI confirmed Little's involvement in at least 50 murders, the largest number of proven cases for any serial killer in United States history. His alleged killing spree ended around 2005. 6 6 Who were Samuel Little's victims? Litter preyed on sex workers, drug users, poor and mostly Black women. It wasn't until 2018 when he began confessing his crimes to Texas Ranger James Holland, who was question Little about a killing, which was later determined he did not commit. Authorities across the US are continuing to search for some of the bodies of Little's victims,.