Effecting 10 million drivers. Nightly news begins right now. Good evening. From the campus of Catholic University of america, behind me the basilica of the nationalal shrine of the Immaculate Conception where pope francis will sell bright mass tomorrow. The first journey to america began late this afternoon. Welcome to washington, planeside by president obama and a cheering crowd. Following his threeday trip to cuba. For american catholics, the next six days offer a chance to see and touch a leader who is inspired with his humbleness and compassion and mercy. But his outspokenness on matters of world afears means this visit is seen through a political lense. We begin with peter alexander. Quite a welcome today. That is right. This is a historic trip. Pope francis is now in for the night. But his arrival has energized so many americans, including 70 million american catholics. His holiness today made history, touching down outside of washington, franciss first visit to the u. S. Joined by president obama and the first lady at andrews, so rare a president has only done it once before. And the father showing attention to school children. And he left in a fiat, carrying his secret service detail. Aboard a jet dubbed jeb one. He would not bring up the u. S. Embargo on cuba saying this is a pastoral trip, not a political one. In cuba, a remarkable reception with the pope calling for a revolution of tenderness. Today thousands lined the streets to green francis as he made a surprise visit at the cubas holy shrine and taking photos with some of the hosts. And even castro was impressed, meeting finally with him today for the third time. Carrying his own briefcase as he boarded a flight to the u. S. Awaiting in washington, a city known for tight security, police everywhere, closing streets and putting up barricades an everywhere is excitement. There it is, going pipe and there is the pope. Were focusing on the message of love and mercy and the joy that he brings to all of us here. Francis will visit with the president at the white house tomorrow. On thursday becoming the first pope to address a joint meeting of congress. Speaker boehner today tweeting the vieh he will see while visiting the capitol. While here he will parade along the National Mall and celebrate mass at the Largest Catholic Church in the u. S. Tonight he arrived in what is the vaticans embassy, located directly across the street from the Vice President mansion. Now at the center of democracy. And in a city not known for spirituality, reflection, what has stuck me so much is how much of a reception. And there was a call from a cardinal and saying take care of our pope and he wasnt a catholic. Peter, thank you very much. Anne thompson was with the pope on the way to the u. S. And during the flight he took a question about the message he hopes to deliver during the historic visit. Ann joins us live from joint pace andrews. What did he say . Lester, i can tell you it is was an energized pope francis talking to reporters after three long hot days in cuba telling about a woman thinking he is the antipope because he doesnt wear the red shoes. The pope knows he has the worlds attention on this trip and we expect him to use it to hit some favorite photographer sis themes. First of all climate change. He believes that developed countries like the United States owe a debt to developing countries for all of the Carbon Monoxide they have spewed into the air. Immigration, he has asked everybody to adopt refugee family. Might he do the same here in america. The plight of the poor. Le have lunch with the homeless here in d. C. And the important of family is the topic when the pope travels to philadelphia over the weekend. The hope told me on the plane he is anxious to meet the american people. And he gets the first chance around the ellipse tomorrow. Lester. Anne thompson, thank you. And a story sparking widespread outrage. About a drug company that jacked up the price of a life saving medicine by a staggering 5,000 and the young ceo is taking major fire about it all. Andrea mitchell has this report. Reporter he is the face behind the latest out cry over alleged drug price goublging. The former hedge fun manager who touring pharmaceutical bought a drug called dara prim overnight and boosting it from 13. 50 a tablet to 750 a pill. This is the more appropriate price for dara prim. At this price it is still on the low end of what or fan drugs cost and were not the First Company to raise drug prices. Reporter he said it was for Research Money to develop a better drug, but dara prim used by those with infections, sometimes contracted by aids and cancer patients, has been around for 62 years. We dont need another drug in this space and there is no indication that this guy has any idea how to do Drug Research and development. So i dont think this is a welljustified argument at all. It is simply exploiting a niche drug. Reporter after a public out cry, Cnbc Meg Tirrell asked if he would consider lowering the price. After all of this attention and doctors cant access the drug, are you going to change the price . No. He was blasted online and tweeted lyrics by a song by eminem. It seems like the media immediately points a finger at me so i. 1 back at em, but not the index or pinky. But tonight under pressure he has backed down telling nbc news he will in the next few weeks lower the price to either break even or make a smaller profit. It is easier to see a large drug price increase and say gosh those people are gounling but when you find out the company is not making money, what does that mean. It is easy to villianize people and were in an election cycle where this is a very tough topic for people and very sensitive. Reporter and indeed, with drug prices skyrocketing here in the u. S. And not the rest of the world, it is a campaign issue. With Hillary Clinton today holding a plan to hold Drug Companies accountable for lowering their prices. Lester. Thank you. And also under fire, the largest automaker in the world and under federal investigation after getting caught cheating by installing hidden software on vehicles to get around air safety standards. For 10 million drivers affected by this, Pete Williams has details. Reporter volkswagen tonight is in full throttle apology gear, admitting it installed software in the diesel models that allowed them to cheat on air pollution emissions tests and claiming they were selling an environmentally friendly car. Our company was dishonest with the epa and the California Resources board and with all of you. And in my german words, we have totally screwed up. When the cars were being inspected with only the front wheels turning on the test bed, hidden software turned on the pollution controls. It went off when the cars were back on the road, increasing fuel economy and performance but allowing emissions of a Greenhouse Gas known to cause smog and gas up to 40 times higher than the standard. They said this was a environmentally friendly vehicle. They lied to consumers. It was in about 480,000 diesels, 20092015 jetta, beetle and golf and passats and audi a3s. They have been ordered to stop selling the cars and set aside more than 7 billion to fix the cars in the u. S. And 10. 5 million more of the diesel models elsewhere around the world. The ceo Martin Winter korn is sorry volkswagen violated the trust of the customers. Now the company faced potentially billions in fines for violating filter laws and a criminal investigation from the Justice Department and a huge challenge in winning back trust in the brand. Lester. Pete, thank you. Lets turn now to news that broke just as the countrys attention was focused on pope francis touching down in the u. S. Hillary clinton wading into a hot button issue, announcing her opposition to the Keystone Pipeline. A decision that already has republicans pouncing. Chuck todd has late details. Under pressure from environmental groups and from democratic opponent bernie sanders. The secretary can agree and disagree. But i think you got to have a position. Today Hillary Clinton finally made her position on the Keystone Pipeline clear. I oppose it. And i oppose it because i dont think i dont think it is in the best interest of what we need to do to combat climate change. Clinton began the Environmental Review process on the final 1200 miles as secretary of state. She said she didnt want to secondguess barack obama on an issue she worked on. But last week she signaled she was finally ready to weigh in. I am putting the white house on notice. Im going to tell you what i think soon, because i cant wait. Reporter critics who support the pipeline said it will create jobs and drive down oil prices. Why doesnt she, Hillary Clinton want to build a pipeline . Reporter the state department estimates construction would support 42,000 temporary jobs and once operational it would support 35 permanent employees and 15 temporary contractors. Now lester, ironically, four years ago as secretary of state it was widely assumed she was okay with approving the pipeline. Now president ial politics and environmental pressure put her on the side that she is on. But the reason there is a delay from the whus in coming out for or against is that it is a diplomatic issue. Canada wants this and they are a close ally and thats why there is a delay in the president announcing his own position. Lester. In the republican race, donald trump is locked in a war of words with the latest sparring partner, a surging Carly Fiorina. While ben carson continues to defend remarks he made about islam on meet the press which some found inflammatory. Hallie jackson has more. Reporter under fire for his controversial comments about muslims, ben carson is a casualty of the p. C. Police. P. C. Culture says whenever you are asked a question it has to be answered in a certain way. And if you dont answer it that way, then lets attack. Reporter carson today, tripling down on his remarks the islamic faith is unconstitutional as those like kaepernick respond. Anyone of any faith is welcome here. Reporter campaigning in South Carolina today she had a microphone moment that everyone heard. Contrary to some caricatu caricatures, im quite soft spoke. From donald trump who is attacking her online and on air. If you hear here you get a big fat beautiful headache. And now taking target at fox news and Host Bill Oreilly who laughed it off. This is just theater right now. He gets a lot of attention from the theater. The frontrunner turning his attention to Carly Fiorina and turning up the sign he is sweating her fast rise in the polls. Her campaign thinks say. Saying we get the point, mr. Trump, you are worried. You should be. But her critics say she should be worried on the strength of her Campaign Organization and the history as the fired ceo of hewlettpackard. Im concerned you will spend this campaign defending your past Business Record versus looking ahead. Im not concerned at all. Im happy to defend on my past Business Record. I will run on that record all day long. Fiorina, trump and carson not just the top three in the race but the socalled outsiders who have never held elective office. The last time voters picked a president without a political position and hadnt been elected, more than 60 years ago. The candidate, dwight eisenhower. The power of dday, so powerful, both parties wanted to get him to run. Thank you. Still ahead, medical mistakes that will happen to nearly every american, sometimes with fatal consequences. What every spacious should do to protect themselves. And terrifying moments in the water caught on camera. Moments in the water caught on camera. How a kayakter with the pain and swelling moments in the water caught on camera. How a kayakter of my moderate to severe rheumatoid arthritis. Ordinary objects often seemed. Intimidating. Doing something simple. Meant enduring a lot of pain. If ra is changing your view of everyday things orencia may help. Orencia works differently by targeting a source of ra early in the inflammation process. For many, orencia provides longterm relief of ra symptoms. Its helped new ra patients and those not helped enough by other treatments. Do not take orencia with another biologic medicine for ra due to an increased risk of serious infection. Serious side effects can occur including fatal infections. Cases of lymphoma and lung cancer have been reported. Tell your doctor if youre prone to or have any infection like an open sore, the flu, or a history of copd, a chronic lung disease. Orencia may worsen your copd. If youre not getting the relief you need. Ask your doctor about orencia. Orencia. See your ra in a different way. Its easy to love your laxative when that lax loves your body back. Only miralax hydrates, eases and softens to unblock naturally, so you have peace of mind from start to finish. Love your laxative. Miralax. Therthat can be serious,ere. Even fatal to infants. Its whooping cough, and people can spread it without knowing it. Understand the danger your new grandchild faces. Talk to your doctor or pharmacist about a whooping cough vaccination today. Were back now with a staggering new report about a dangerous blind spot in our health care system. It concludes that every single one of us will get a wrong or late diagnosis at least once in our lives an that can lead to very grave consequences. Nbcs ron mott tells us more. Reporter 12yearold rory dreamed of becoming a pilot. But a seemingly simple cut on his arm in gym class killed the new york city preteen leading to a blood infection that was caught too late. Our son died and our son died despite us raising our concerns that there was something wrong. We were told over and over again that this was a stomach virus. A new report about the National Academy of Sciences Engineering and medicine concludes misdiagnose is conclude in one out of ten deaths an one in 20 americans misdiagnosed every year. It is a wakeup call researchers say, demanding more attention. We found diagnostics is much neglected in health care and we need to study it more to do anything about it. The solution, researchers recommend changing the pay structure for doctors to emphasize the time with patients and elevating the stature of nurses who spend the most time with patients and improving the process. Ask for the tests and more than the test ask for help understanding the tests. Peggy zucker man of los angeles said her Kidney Cancer was misdiagnosed as a stomach ulcer and now advises patients on how to talk to the doctor. Number one, know yourself and your story. You need to know what brought you to the doctor, what were your symptoms, what youve done. Did it make sense to you and did the doctor fully listen to you as you gave your diagnosis . A call to decrease medical misdiagnose is on uncovering what is really ailing us. Ron mott, nbc news, boston. Were back in a moment with a tradition that fans are kissing goodbye at a College Sport every insurance policy has a number. But not every Insurance Company understands the life behind it. For those whove served and the families whove supported them, we offer our best service in return. Usaa. We know what it means to serve. Get an insurance quote and see why 92 of our members plan to stay for life. Pope francis isnt the only dignitary visiting the u. S. And causing road headaches. Xi jinping arrived in seattle for a three day visit. His motorcade snarled traffic downtown where he was greeted by protesters, not over the trax, but upset over the human rights record. Later in the week he will be welcome for a state dinner at the white house. It is a regular future at sports events, the kiss cam. Like last week with the carters locking lips at an Atlanta Braves game. One place you wont see it is at cuse. It is getting rid of it after complaints when men force ably kissed women that were clearly saying no. Some fans say it sends the wrong message at a time when colleges are dealing with sexual assault. And battle with a hammer head shark as a kayaker walloped the shark repeatedly but the shark wont give up. For 15 minutes, it circles and rams the small vessel over and over. Even after the kayaker made it so safety, he said the shark swam near shore waiting for him to come back. It looks like this one was person. When they come back, they just got the honor of the young where our next arrival is. Red carpet whoa toenail fungus . Fight it with jublia. Jublia is a prescription medicine used to treat toenail fungus. 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