the republican party slow march into autocracy, led by donald trump. the one day dictator wannabe. in a speech last night at the new york young republicans club gala, the gop front runner did not back down from his comment last week that he would only be dictator on day one of a possible second term in office. instead, he doubled down on it. >> baker today, in the new york times, he said that i want to be a dictator. i didn't say that. i said i want to be a dictator for one day. but the new york times said, and you know why i want to be a dictator? because i want a wall, right? i want to wall, and i want to drill, drill, drill. >> reporter: for all the lying that he does, there is no reason not to believe him when he says he wants to be dictator for one day, what is unbelievable about it is that trump, who is not known for his restraint himself discipline, we only want to be dictated for a day. it is significant and disturbing escalation of rhetoric even for donald trump, because of how bluntly an openly he is telling us all about his autocratic plans for a second term. during last night's speech, trump also issued a thinly veiled warning to president biden, saying that the criminal indictments against him have, quote, opened up a pandora's box that may never let our country be the same. trump's most subservient allies are falling in line as well, picking up on these themes of retribution. at the end of last month, robert kagan, and other large for the washington post, edited a lengthy piece about the increasing availability of a trump dictatorship. in response to kagan's, because ohio senator j.d. vance sent a letter a few days ago addressed to attorney general merrick garland secretary of state, antony blinken, seeking an investigation into kagan. a journalist. vance, by the way, is one of the names being considered as trump's running mate, according to a recent report by axios. kagan is far from the only one warning about the erosion of democracy in america. trump's open admiration for autocrats and strongman tactics have caught the attention of a broad swath of people, just a few weeks ago, the economist declared that trump, quote, poses the biggest danger to the world in 2024. in a recent media blitz for her new book, former publican congressman liz cheney has given a lot of sharp criticism about how america is, quote, sleepwalking into dictatorship. she's even gone as far as to say that it is quote, so important, the republicans not being the majority in 2025, which is a remarkable statement for someone who is a senior member of house republican leadership up until two and a half years ago. meanwhile, with the first nominating contest of 2024 just five weeks away, the latest issue of the atlantic magazine considers in full what a second trump term might be like. the atlantic's message is clear. if donald trump is able to wield power again, the harm he could cause would be full and complete. he could inflict lawn lasting and possibly irreversible damage to american democracy. as we've heard a straight out of trump's mouth in recent months, he's prepared to unleash a torrent of abuses on immigrants and citizens alike, especially to those who dare criticize him. he is an effort to upend american foreign policy at the risk ofiminishing our standing in the world. and the second trump term uld leave a lasting legacy of corruption. as the atlantic staff writer franklin fo notes, the first ump administration left power havi cpiled for public office for private gain. atnow-how, that confidence, and their owimpunity, that savvy understaing of how to profitably deal with malignant interest will inevitably be applied to plants for a second term. if the rstrump presidency was, for the most, part in improvised exercise and petty corruption, a second would likely consist of systematic abuse of the government. there's a term to describe the sort of regime that could amuse on the other side, a mafia state. joining me now is eric newman she previously advised the attorney -- she was the attorney adviser the office of legal counsel made portman of justice during the trump administration. now she is council for the nonprofit group, project democracy. also with this is the aforementioned franklin foer, staff writer for the atlantic. he is the author of the book, the last politician inside joe biden's white house, and the struggle for america's future. good morning to both of you for an important conversation. franklin, i was at lunch yesterday, not yesterday, but tuesday with an old friend who thought this here on fire stuff is nonsense. so we agreed that when we leave lunch, he is going to pick up a copy of the atlantic and read the series of articles. and we would discuss. then we would go through it, because they are evidence based. i would not necessarily thought that you needed to do that, but basically, you and your colleagues the atlantic have run the alarm. you've said, this is serious. there is still a way out. >> it's a genuine emergency. i think liz cheney has used the term, sleepwalking, is appropriate. because we are marching into the scenario. there is a lot of ways in which people look back on the trump years, the first set of trump years, and they, say you know what? it was not that bad. we as a country survived. but i think what we wanted to illustrate here, item by item, area of policy by area of policy, area of governance by area of governance, is, that in the first trump term, a lot of the norms that govern the behavior of a president started to shift especially within his own party. that trump over the course of those four years, started to test the limits of what he could get away with. and on the other side of the presidency he walked away with a sense of a genuine impunity. he saw that when he tested the limits there were in fact no limits. his party was able to let him get away with whatever, essentially, he wanted. so when -- if trump returns to power in 2024, he would likely do so with a unified control over congress, and he would do so with this knowledge of how he can exploit the system to punish his enemies, to enrich himself, to enrich his friends, and to, most fully enacted this edition that he has been articulating all along, which is essentially a vision of autocracy. it would now come to fruition. >> reporter: erica, it's flawless, franklin's argument, in the arguments that are put forward in the atlantic. it is worthy of debate, absolutely, but he is correct. here is what i hear from people. for all of this talk, donald trump can break anything. now in the abstract, he broke a lot of things, including the republican party and peoples faith in democracy and people trust their votes can be counted, and all that kind of stuff. but the argument is that the institution held up. so i would be different in the second term? >> thanks for having me, ali. thank you for having this very important conversation. what's different now is that our guardrails are weaker. when all of this started, 2015, 2016, people laugh at the idea that we wouldn't have a peaceful transfer of power, that the vice president would not show up and count the certificates, but there would be a mob attack in congress. not to mention the corruption that franklin so well details. the corruption of the department of justice, that we saw in the trump administration. i would also point to the people who are raising the alarm bells the first time around. we had -- writing a so-called here on fire piece in 2016 or 2017, here he is again, saying the same thing. you had bob kagan in may of 2016 saying, do not elect donald trump. this way goes fascism. and now he is raising those same warnings again. these people have credibility. and we should be paying attention. >> reporter: and the ohio senator j.d. -- jaime vance is looking into investigation, something that franklin cash patel, one of trump's insiders, has said will happen in the next administration. they said they will specifically go after journalists. we will go after the media. donald trump has spoken about this network as president, which is by a whole lot less bad than what he said about members of the military, who should be executed. they are all saying it. they are all saying the quiet part out loud. and yet, i still have to have these discussions with people, and you still have to have these discussions with people, and you still have to publish those. why? what is the disconnect? what is going to be the thing that makes reasonable people, no matter where they are in the political spectrum, say, i am for democracy first, fanned than partisan politics and being a lot of the political spectrum second? >> -- had a phrase in the new york times that encapsulates a lot of the way people thought about the first trump presidency, which was, malevolence tempered by incompetence. and we hear these hateful things, but at the end of the day, donald trump is a blow hard, he doesn't follow through on what he says, it is all just optics, it's theatrical, but what i think is so different this time is that the plans have been hatched. it is not coming in with a sense they are just going to fake their way through at this time. you look at something like, the obscure part of presidential personnel hiring, an order that is called, schedule death. trump railed against the deep state. he felt like they were all of these obstacles within the bureaucracy, that were impeding his vision. this time, a lot of smart people in the maga movement have come up with a very well in detailed plan to purge those bureaucrats, that part of the deep state, to change the very regulations that govern the civil service. this is not a buffoon early this time around. this is well conceived, there is a plan that can be executed, plausibly, and effectively, at the very beginning of the presidency, which would eliminate all of these guardrails, all of these impact mints, and those impediments would not be there for the rest of his term. >> reporter: that's an important one for us to study. >> repor>> reporter: there's anr one going on, erica, not on the deep state, but a lot of conservatives are calling the administrative state. there is a couple of cases before the supreme court right now, in which the result could be, the dismantling of government agencies. that may sound abstraction to some people who are watching this, why do i care about the epa, or the s.e.c.. but it actually plays into the hands of a president who would be king. >> this is exactly right. the administrative state is how the government delivers goods and services to the american people. and part of trump's plan, he writes about the so well, is to get rid of what the government can do for the american people, and turn the government into his own, personal kingdom, with his own palace guard, serving him, lining his own pop get book. getting rid of the administrative state is a way to make sure that we don't have clean air, we don't have clean water, we are spending money on delivering those goods and services. instead, everything is just about appreciating in strengthening donald trump, and then increasing his power over all the things that we are paying taxes for. >> reporter: i'm going to ask you to to stay here for a moment, because i wanted to get quick break, we will come back and continue this conversation on the other side. erica newland and franklin foer, thank you for staying with. me velshi continues after this. i continues after this chase. make more of what's yours. struggling with the highs and lows of bipolar 1? ask about vraylar. because you are greater than your bipolar 1, and you can help take control of your symptoms - with vraylar. some medicines only treat the lows or highs. vraylar treats depressive, acute manic, and mixed episodes of bipolar 1 in adults. proven, full-spectrum relief for all bipolar 1 symptoms. and in vraylar clinical studies, most saw no substantial 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(vo) it's your last chance to turn any iphone in any condition into a new iphone 15 pro with titanium and ipad and apple watch se - all on us. only on verizon. >> reporter: i never one of the commercial break ten so fast, i need to get back to this conversation with our guests to seek -- and franklin foer, staff writer the atlantic. i'm not going to commissioner anything, but i've told everybody that i met by the sitting, rated and argue with everybody around you about it. in your piece, specifically, you point out corruption in the first trump administration, and you are saying that it pales in comparison to the complex system of patronage in a country, use hungry as an example. but that trump could change it. he could have evolved into that sort of thing, tell me about that, tell me about how you see that happening. what have the trump's learn from the term first time around that could actually change us into a place like hungry? >> during the first time around, if you are corrupt interest, you are trying to change government policy, you knew that if you spent a bunch of money at a trump property, at one of his golf clubs, or mar-a-lago, or any of these places, that you would have a chance of influencing the way that government made its decisions. that is kind of petty corruption. but before the break, we started to talk about schedule left, and the trump plans to change the bureaucracy, to clear out all of these people in these lower government posts who trump considers to be disloyal. and so, in the place of what those longtime civil servants, you have a bunch of trump cronies getting hired, whose interests really don't reside with the american people, or the common good, or office, they reside with trump himself. and those people, those hacks to get put in power or people who are almost definitional going to be inclined towards that corruption that we see in foreign countries, for friends punishing foes. and so since there's no guardrails that's going to proliferate a major sort of way. and we see a system start to form, where we have the middle getting extremely rich off of the government, and people on the fringes also lining their pockets off the government. and the system becomes self protective, where everybody needs to protect the guy at the top, to protect the system itself, from its critics outside of the system, from legislators outside the system, from journalists. and so the corruption actually has the effect of further spawning and further entrenching the autocratic interest. >> reporter: erica, part of the problem part of the reason everybody can't discuss this really is because, to some, people it still feels like an abstraction. one of the reasons you are on the show this morning is because you were in the department of justice from the end of the obama administration into the first couple of years of the trump administration. so you are on the inside, and you saw firsthand how things change, and how they happen in realtime. we all talked about from the outside. what is going on in the permit of justice, what is happening. how do you detect, how did you detect that something was amiss? how do you detect these cracks in the foundation? >> well, within the department of justice, what i saw was extremists pushing the law beyond where it was. and accepting president trump's, quote, alternative facts. not holding us to a standard of reality in the governance. one of the things that was so hard when i was there, when you are in that bubble, is keeping your perspective, and not letting this get normalized. and i think that is a message for the american people. we have to stay alert. things that seemed abnormal for seven years ago seem normal now, and we lose our own sense of guardrails on that. and here, we should listen to the courts. the courts have been telling us, just in the past two weeks, the courts have rejected three times trump's attempts to say, he is different, he is above the law, because he was president, he can do anything that he wants. we need to listen to those voices so that we don't accept this as normal, and sleep walk our way into a disaster. american people have not made the choice. yet we can still get out of this. >> reporter: franklin, one of the things, we use hungry as an example. you can choose many countries, but hungary is a great one. before the last elections in hungary, i spent a lot of time in budapest because of the ukrainian war. everybody around, me everyone i talked, to said that there is no way viktor upon is when the election again. this time, it'll be different, every realizes what it is, just like brexit. the polls come, in and everybody in budapest voted to throw viktor orban out, and everyone in the entire rest of the country voted him back in. i was in london the day of the brexit vote. same thing. how to present the people i talked to said there's no chance this is going to happen, and everyone in the rest of the country voted that way. how do we have people figure that out in america? that that is a similar situation, that people around you may be saying, it's all going to be fine, it will all be fine, that a whole bunch of people who think this is existential for them to get back into power to perpetuate these things you write about? >> one of things that happened and hungry for sure is that the opposition to viktor orban grew both complacent, and it was a sense that they couldn't actually change things, in the end, and the opposition fought amongst itself quite a bit. and it never really jailed in the sort of way that you are describing, where the existential threat to democracy snaps into place, and the opposition responds with this sort of urgency that the situation requires. i think what happened in both brexit, maybe even 2016 would certainly have been, and the opposition and starts to complain about their own guy and other start to bellyache about their own fight, they start to lose track of the big picture and the big picture here is that, you have a guy who's promising to wipe out the civil service, to install internment camps, to round up immigrants. to deport them. we are talking about extremely major threats to our democracy, from which it might be very hard for us to recover, as has been the case in hungry. >> reporter: thanks to both of you, important, important discussion, thank you for the work you've done on. this erika newland is a former attorney adviser at the office of legal counsel in the department of justice. frequent foreign staff writer at the atlantic, to get everybody to pick up a copy of the atlantic will read it online. this is really important for democracy state. both of you. coming up next, many are calling israel's violence attacks on gaza a disproportionate response to the october 7th hamas attack. it is causing more american voters to support pause for a cease-fire. ase-fire ase-fire -go! -unnecessary! -go! -unnecessary! -when you can take this phone, you'll be ready. -make the unnecessary, unnecessary. let your employees do their own payroll. it's the perfect menu lineup. just give us a number, we got the rest. number three? the monster. six? the boss. fifteen? titan turkey. number one? the philly. oh, yeah, you probably don't want that one. look, i'm not in charge of naming the subs. ♪♪ vicks vapostick provides soothing, non-medicated vicks vapors. easy to apply for the whole family. vicks vapostick. and try vicks vaposhower for steamy vicks vapors. >> reporter: despite initially receiving ample global support for its military offensive against hamas after the october 7th attack, israel is now facing increased criticism for what many are calling a disproportionate response in gaza. the relentless bombing is killed about 17,700 palestinians, most of them women and children, and that's according to the gaza ministry nbc news cannot independently verify those numbers. military operations have apsed, and aid workers, along with thecivilian their lives.are pleading for just off today, the biden stration bypassed congressional rules to authorize the sale of 40,000 take shells to israel, worth about 100 and $6 million. tank shells are the artillery, the ammunition that tanks used. and on friday, the u.s. vetoed a resolution calling for a cease-fire in israel in gaza. public sentiment tells a different story. the majority the american public, 55%, are now calling for a cease-fire, according to a poll to at least late last month to the economist and yougov. the numbers even higher among democrats, with 77% calling for a cease-fire. a reuters poll from 2017 called for a similar outcome, 65% of americans called for a cease-fire, but remarkably, in a time for significant evasion on various issues, there is growing consensus among americans for a need for a cease-fire. in fact, many of the organizers behind a growing number of rallies calling for them are jewish americans, with rallying cries that include not in our name, and cease-fire now. and now, some larger american jewish groups or having that same discussion. on thursday, more than 500 staffers -- across the country, and synagogues tinnitus centers, and philanthropic organizations signed an open letter urging president biden to's call for a cease-fire. the state support for the public to know that there is, in fact, quote, broad support within the jewish community for a cease-fire, and quote. the letter reads, quote, we are individuals who are for a ride away of jewish organizations across the united states coming together across the broad land of beliefs, practices, backgrounds, and identities, that make up the rich fabric of the american jewish community. we are uniting together in this moment to call for a cease-fire, the release of all hostages, and the commitment towards a long term political solution that ensures the freedom and collected safety of israelis and palestinians, and quote. f e signatories come from pro israel groups that opposed a cease-fire,the j street, esare the advocacy group. on thursday, terry also announced that it was reconsg itstance, saying, quote this is a moment oftrutfor the u.s. israel tiship. u.s. security assistance an entitlement program to provided in therm oa blank check. if we do not see evidence to know the government of israel is, in fact, meaningful changes to its conduct of the war, and its attitudes regarding postwar arrangements, that j street will no longer be able to provide our organizational support for the current military campaign, and que. for more on this, i'm joined by jeremy ben-ami, he's the president founder of j street. he's also the executive director of j street packed, and the author of the book, a new voice for israel, fighting for the survival of the jewish nation. jeremy, thank you for being with us this morning. i appreciate it. there's a lot of nuance to this discussion, and it's we are in a world which we are in where we say someone's a cease-fire, it's one mix descriptions about who you are and what you think. you are trying to bring that nuance to this conversation. so can you help me, i'm trying to give an explanation of what's going on. but can you let me know, what is the current stance of j street, and how has that changed? >> i think j street represents a very central voice within the american jewish community. we are people who have deep, deep connections to israel. we have family, we have friends who were affected by october 7th, in the deepest way. we know people who are hostages still in gaza. and we support israel's right to self defense. we understand it can't live with groups like hamas armed and ready to attack it constantly on its border. and we are not pacifists. we understand that there has to be times of military response to a military threat. so we do believe that israel has this right to self defense. yet, at the same time, we look at what is happening in gaza, and we understand that not every effort is being made to minimize the harm to civilians. not every effort is being made to maximize the math of humanitarian assistance. this government of israel has no commitment to a political resolution of the underlying conflict, with the palestinian people. there is only a political resolution to this conflict, and it has to involve self determination, and freedom for the palestinian people. so we have real problems with the way that the israeli government is pursuing this campaign, at the same time, we've seen with the israeli people, and understanding that they have every right to pursue justice against those who took their people an attack and killed are people on october 7th. >> reporter: so there is nothing weird about your position, however, there are people, here and in israel, who have argued that peoples hold views or express views like yours are outside of the mainstream. we have 16 or 17 senators, i spoke to senator van hollen this morning, who were asking for ways of thinking about the aid that we give to other countries, and conditioned them on humanitarian conditions. tell me about, is there an evolution here, is there somewhere that this could go that could become reasonable and meaningful? into the question of aid and senator van hollen's amendment. the unites it spends trillions of dollars a year on a wide wage of programs, domestic and foreign. every single dollar that we spend council strings attached. >> reporter: we see the people, whether you're building low income housing or providing food to the hungry, or providing assistance to people abroad through our foreign aid products, hear the things we need to do. here is what our money is for, and here is what it cannot be used for. and with senator van hollen is saying is that the money we provide to the state of israel as it pursues its honor to have justice for october 7th, that there are certain things that can't do with our money. and that is a very, very reasonable approach. it is right down the middle of what should be american politics. you want to have money from the night states, then you have to use it in the way that follows american law and international law. >> reporter: much of the broader american public, the divide on this issue becomes most pronounced if you look along generational lines. one of the individuals who endorsed the open letter that i tabout in the introduction expresses the jewish organizations might alienate youngerjews if they for israel.cal of their he told nbc, quote, if you're atg an entire generation of american jews, who is going bthe next generation of leaders and doers and members, if so many people my age and younger don't feel like they need these organizations, or have a place in them. i'm terrified that they want to my children -- >> look, i empathize deeply with that view. and several members of my own staff signed that letter. i am very proud of my children, my children's generation, that they have a very deep commitment to justice. they understand the question of oppression. and what happens on a daily basis between the state of israel, the palestinian people that there are rules out there without providing them with equal rights, is something that this generation, this younger generation of jewish americans is very committed to fighting to correct. and i could not be more proud. the government of israel, even as it is pursuing this military campaign, is at the same time, turning a blind eye to radical settler violence on the west bank that is displacing palestinian families and displacing palestinian militants. this is simply not in keeping, not only with the values of united states, but not keeping with the values of the jewish community, and the lessons that we should have learned from our own history. so i very much respect and stand with the people who are standing up for justice, and for oppression who are in the american jewish community, and particularly young people that i think we have raised really well. >> jeremy, good to talk with, you the president and founder of j street. he's also the executive director of impact. still ahead, at least six people are dead after multiple -- late tennessee yesterday, we're gonna bilious from the ground, next. a bilious from the ground, next vicks vapocool drops. vaporize sore throat pain. my most important kitchen tool? my brain. so i choose new neuriva ultra. unlike some others, it supports 7 brain health indicators, including mental alertness from one serving. to help keep me sharp. try new neuriva ultra. think bigger. we come from people we can be proud of. seeing all the places i come from, i know. if it's a serrano, it's something to be proud of. give the gift of family heritage with ancestry. >> reporter: all right, we're following breaking news out of tennessee, where at least six people are dead, including for the people that are -- up to the middle of state, late yesterday. three people, including a two-year-old boy, were killed in the nashville area. the states capital, another three were killed, in the town of clarksville, which is around 50 miles northwest of nashville. the mayor of nashville hasn't declared a state of emergency, the severe weather destroyed homes, businesses, and downed power lines, and as of this morning, nearly 44,000 people are currently without power across tennessee. i want to go right to nbc's marissa perez on the ground for us in madison, tennessee, right side of nashville, which is one of the hardest hit areas. i'm just looking at that image around two. you that is something, what are you seeing, what are you learning? >> reporter: yeah, you just mentioned the three fatalities in this area. that was actually just on the street from where we are right now. this is nesbit lane, this is the name of the street and this is some of the worst damage that we're seeing in tennessee, in addition to clarksville, and i want to have you take a look at what you're seeing here. because not just the destruction of the homes, and you'll probably spot people walking around with trash bags, with garbage bags, you trying to salvage whatever is left. you know, i spoke to a homeowner inside of here. and thankfully, he wasn't in that bedroom, because you can only imagine what would've happened if he was. we've spoken to so many people where there were so many close calls. just down the street, the two mobile residences. the man who is inside a mobile home that rolled over on to the residents, where that woman and her two-year-old son were inside. it was just awful. and then, ali, i want to take you to video that we've seen overnight. striking images of the tornado itself, you can see it not just tossing around debris which is now expected to see a tornado, but also igniting fires that were even small explosions. and then of course, the aftermath the destruction. we are talking a greatly at nesbit lane, here in madison, because that's where we're seeing a lot of destruction. but, also clarksville, tennessee. it's about an hour or so away from where we are, northwest, and that is where we also saw three fatalities. of course, all of us are waiting to find out more about the people who lost their lives here. but in terms of what i am seeing on the ground here, you can imagine a lot of times, in the worst moments, especially with natural disasters, you see the best of humanity. so people are out here helping their neighbors. we've heard some remarkable stories of exactly that. the red cross is assisting with people who have been dealing with everything. as you mentioned, there is still tens of thousands without power, people leaning on each other to get the basic necessities. but just a lot of people have spoken to who are just grateful to be alive right now, ali. >> reporter: people always ask me, what are the most meaningful interviews you've had, it's not anybody famous. it's people coming back after some sort of disaster. because that's where you actually see the greatest strength of the human spirit. marissa, thanks, stay safe, thank you for your great coverage of this in outside of nashville, tennessee. coming up next. humans are lugging -- living longer, but they're not unnecessarily living healthier. new top scientists around the world are working to change that by targeting the aging process rather than fighting specific diseases. and if they are successful, it could improve the quality of life for millions of people. for millions of people. for millions of people. oh. 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deal on the subway app. buy one footlong, get one 50% off in the subway app today. now that's a deal worth celebrating. man, what are you doing?! get it before it's gone on the subway app. ♪♪ >> reporter: over the last 70 years, average global life expectancy is increased by more than 25 years. and while scientific and social advancements have allowed us to live longer, not necessarily living healthier. age related chronic disease has an impact on nearly every person over the age of 60, a disease that is associated with aging have huge human economic costs. now doctors and scientists around the world want to combat the health challenges of getting old by combatting aging itself. no most of the researcher and health and aging has focused on the lifespan. that is how long you live, this is global, the average global lifespan is 73 years. but a newer area of study focuses on something called health span, which is the period of your life if you are generally healthy, globally, that is thought to be 64 years, when you don't have any serious or chronic illnesses. it focuses on the quality of life rather than the length of your life. according to data collected by the national institutes of health, we are looking at 64 years. and as you can see, the average lifespan is about 20 years longer than the average health span, meaning that most people spend about the last 10 to 12 years of their lives in poor health. now, as we age, our body undergoes changes, and a whole variety of factors, from our genetics, to the food we eat, to the amount of daily stress we encounter. and where we live. all of that contributes to the aging of every single cell in your body, at varying speeds, you can literally see cell changes under a microscope. and there is a long list of diseases that are directly associated with the biological aging of the body, inflammation, alzheimer's, physiological decline. but top scientists around the world by targeting the biological aging process, not the diseases themselves, most age related diseases and ailments can be prevented, if not slowed, or put off by years. addressing health span would not only improve quality of life for millions of people, but could also have a major economic impact. currently, in the united states, people over the age of 65 account for about 17% of the population, but they account for approximately 38% of all spending. we spend a whole lot more on people in their later years of life. the science on addressing health span is something that we are looking at right now. it is combatting aging, it is an emerging science, but it is very new. and with the global population above 60 set to double to more than 22% by 2050, there is a huge individual societal and economic incentives for us to figure this out very soon. enter ex bryce. ex prize raises money to design massive competitions. competitions with multimillion dollar prizes, to incentivize teams from around the world to come up with innovative solutions to some of the world's biggest challenges. the funds are raised to a mix of big and small donors and corporations individually for each prize. by the way, i should tell, you i'm on the board of trustees at the x prize, it's an unpaid role. but last, month ex prize launched its newest and biggest competition yet. ex prize health span. it challenges teams to develop therapeutic treatments that target biological aging rather than to seize. the 101 million dollar prize is going to go to the team that develops a fair pick treatment for seniors, that in one year or less, could restore muscle, cognitive, and immune function by a minimum of ten years, with the goal of 20 years. after a quick break, i'm joined by jimmy justice, executive vice president of the health domain, an ex, prized talk about the science and the competition. competition. know your glucose level and where it's headed. no fingersticks needed. manage your diabetes with more confidence. and lower your a1c. the number one doctor prescribed cgm. freestyle libre 2. try it for free at freestylelibre.us (car engine revs) (engine accelerating) (texting clicks) (tires squeal) (glass shattering) (loose gravel clanking) >> reporter: before the, break i told you that a new competition by the ex prize foundation that aims to develop a therapeutic that targets biological aging. joining me now to discuss this is doctor jamie justice she's the executive vice president of the health domain at the x prize foundation. she is a professor of internal medicine at wake forest university school of medicine, she focuses on aging and giro science. doctor justice, good to see, you thank you for being with us. this is a very exciting one. so i wanted to ask a number of questions that i know my viewers are very interested in. this is 101 million dollar prize. the prize goes to a team that develops a therapeutic that restores muscle, cognitive, and immune function by a minimum of ten years. the goal is 20 years. and it is the target group which is people aged 65 to 80. and they've got seven years to figure this out, right? is that roughly right? but >> you've got it exactly right, ali, thank you so much for allowing me to be here to talk about. it is absolutely audacious, really exciting prize. i could not be happier to lead it. >> reporter: how did you come to these benchmarks? one of the things that folks who don't know the price is that there's always a benchmark. there is a big prize, it's a good prize, but you have to be very specific things. and it has to be audacious, otherwise, everyone would've done it already. but you have to believe that it is attainable. >> reporter: >> absolutely, i've been working in this field, it is an emerging career, but look at the biology of aging as a possible target for a therapeutic development, and the goal here is really not disease based. so we are very specific in this award, and in the mechanics of it, which is those three functions, i'm not specifically looking anyone disease or treatment. what we're really looking at is improving function, and functions that are really important to people. to stay active, to say engaged. things that we like and value so much throughout life, and especially as we get older is the ability to maintain our physical function. being able to walk, and stay fit, maintain our cognitive abilities, so that we can interact with others. we remember that grocery list women go to the store. and we just live through a major international pandemic. i think we cannot really value how important is to have a healthy, and a resilient immune system, so that we can go out, and meet the world's challenges, as we exit our house and interact with others. these are the cornerstones of staying fit, productive, and part of a really growing, aging, community. which, again, aging is a beautiful thing. we have an aging population, and it is filled with really incredible optimism, and really great promise and opportunity. but we have to have solution, so that we can maximize the years that we are given. >> reporter: one of the problems, i'm not sure if it's a problem at all, but the concept of dealing with disease has been hyper specific. right? whether you're thinking about a type of cancer, a very specific type of cancer, or diabetes, heart disease. people fund-raise that way. the studies go that way. you target that learning. it is siloed. i did not even know there was another way to do. it i just assumed, that's what we do. we target all these diseases, and eventually we live longer and healthier. why this different approach? why aging, as opposed to disease? >> you've nailed it exactly. this is the major misconception. when we start talking about aging, people automatically think we are talking about a brutality. and really, we're talking about very practical solutions for a very real problem. and that is exactly it. it's that the number one predictor, the major risk factor for any disease, any major chronic disease, is age. so there have been really incredible modeling work that's been done by jay chance, keith and many others, that have shown it if you actually do target and cure individual diseases, the net benefit on a population level is actually not that great. so, if we actually take the reverse perspective, and start looking at our biological aging, which is actually just another way of studying health in life, if we can really look at some of these fundamental mechanics and these fundamental processes, we begin to find new solutions. both for existing diseases that are really difficult to treat and target on their own, but also the converse. so we find ways to actually improve health across multiple diseases, or, again, really what we are interested in is the aspect of health that is more than any disease. so if we can find ways to optimize, and really approve that quality, i think that benefits to society, both to the individual, and to society, are much greater. so this is the real innocence of the field. >> reporter: and just in use of language, interesting. we're not talking about curing things, and, fact the prize talks about restoring functions. not even necessarily prevention. and that's how we gotta understand. destroying function means versus prevention, versus cure. >> you're right. and it's not really that there is one, yes in the other no, it's not a binary. it's that we have to go tandem. the thing for us is, this is not just a trial. we're actually getting our scientists, getting our public to really start talking about this. is when you assume the aging process is inevitable. so this gives us a new language, where it is not going to be one or the other. in fact, the solutions that we show in the short term, within one year, in a very private will weigh, we can show an improvement in one year. then those are probably going to be the things that are going to have the largest effects on prevention when we start talking about those sort of more clinical disease outcomes. and if we can show improvements in function that are really essential to a whole host of different diseases, and not diseases, just a way to actually interact and be part of our life, then i think even when we are talking about prevention, that's probably going to be the earliest signals that we are going to get four things that can actually extend as what we think of as more of a disease -centric sort of held span. so how do we prevent multiple diseases? and some of them, as i mentioned before, have also had really great opportunities for existing, very difficult to treat diseases. so the impact is multiplicative, and so there is a lot of ways that this could be really useful across. so prioritizing health, and prioritizing function. and that access of health that is more than anyone disease process. >> and >> reporter: i'm booking you for what, seven years from now? that's when we have a deadline? >> ali, come along for the ride. so one of the really great things is that, yes, this is a long prize. because running trials takes time. but we have multiple and points. we're gonna be engaging scientists now. we already have almost 100 teams that have signed up just in the last week. we are going to have early research and development opportunities. there is really great ways for people to get involved. we have clinical trials across the world. this is a global competition. and we would love for you guys to join us on the ride. there is just such incredible people. >> reporter: can't mean. i think you'll hear from a lot of our viewers as well. jamie, got to see you. jamie justices executive vice president of the health domain in this foundation. thanks for watching, check me on every saturday and sunday from 10 am to noon eastern. this monday, and tuesday, on deadline: white house. iraq where you are, inside jen psaki begins right now. ow a