All. Mo rocca will report on our cover story. More than 5 million americans have alzheimers disease. Keep your eyes closed. Reporter which continues to stymie some of the best minds in medicine. But this sunday morning, we will take you to columbia, to meet a family whose unique genetic makeup could provide a road map for fighting the disease. Some of the Family Members believe that illness was caused by a curse that a priest put on their town. Reporter join them for the longest journey ahead. Osgood taking the fall comes easily to the hollywood performers our lee cowan has been ghachg action and i do mean action. Ready . Count off. In the minds of most Insurance Companies being a stunt person is probably not a good risk. Especially when those who do it do it over and over. Anybody can do what we do once, when it comes to take this and you have to keep doing it, thats what we get paid for. The actors behind the action. And why they keep coming back for more. If anyone is a happy guy these days it has to be Pharrell Williams the music and director who trademark happiness who has his own exclusive. We will give him a listen. What happiness is. One of musics Top ProducersPharrell Williams now has a massive hit all his own. Are you okay with being the happy man . I am thankful. The happy man talks about his song, its success and that hat. Ahead on sunday morning. Good morning, joshua. Come on. Osgood matzo is a simple form of unleavened bread that plays an Important Role at this time of year. Nancy giles will be giving us a taste. Matzo is an important part of any passover saider and important part of jewish tradition. Matzo factory on the Lower ManhattanLower East Side they know all about tradition. It is just flower and water. Thats all it is. That is what happened back in egypt. How some of the worlds best matt suppose is made, ahead on sunday morning. Osgood we go on a train ride through the past, aboard a posh pullman car. Martha teichner shows us the work of superstar architect know shah safte, we admire the handiwork of a barber and first the headlines for this sunday morning, the 13th of april, 2014. Federal investigators said they cannot confirm a claim that a fed ex tractor trailer was on fire when it crossed a california freeway median and slammed into a bus full of High School Students and also say there is no sign the truck driver tried to brake before the crash. Ten people died in the collision. Texas, tensions are rising in ukraine, in the east. Pro Russian Forces seized many buildings. Armed men exchanged gun fires with one person who is said to have been killed. The vatican holy week has begun with the celebration of palm sunday services, pope francis celebrate add mass in saint peters square. Thousands turned out yesterday to be bart of a Sports Illustrated cover photo marking tuesdays First Anniversary of the Boston Marathon explosions. Gathered at the finish line were survivors, emergency workers and city officials. Three people died in those bombings, 260 others were injured. Barbara watson and jordan speak are tied for the lead heading into the final rounds of the masters. Goes on to win he will be the youngerest tournament champion ever. He is 20. You can see the masters later this afternoon right here on cbs. Now the weather. Severe thunderstorms are moving across the nations midsection, snow is expected in wyoming and colorado, along the east coast it will be sunny and wonderfully warm. It will be a cool and stormy start to the week in many parts but warm never the southwest. Next, a family affair. Happy. Osgood and,,,,,,,,, osgood this morning, we will be taking the longest journey, the journey that we all face as we, and our loved ones moved into our senior years, mo rocca focuses on alzheimers disease and the possibility that researchers may be turning a corner in their effort to treat and perhaps even prevent it. Keep your hands straight out and close your eyes. Every 60, 67 seconds someone in the United States is diagnosed with alzheimers sees. Disease. Up and down. But the journey to a cure coulcould begin here in south america, in the country of columbia in the city of medell medellin. It is here that we met martha and jose, an ordinary couple with an extraordinary story. Which is plain to see soon after our camera crew arrives in their apartment, they appear to forget we are even there. That is not her real name, her family asked us not to reveal it has alzheimers, a degenerative disease marked by memory loss, followed by loss of motor skills and finally death. Even now while martha can still get around she need constant care. I try to make it so that she doesnt think about the disease, so that she has zero stress. I am in charge of everything in the house, i am with her all the time. The physical burden on jose is great, the emotional burden even greater. It is one of the most painful things in my life, my wife was she seemed like an american. This was a woman who worked 24 hours a day. She was never tired, never at all. She had this amazing emergency to work, and to see her on this downward curve, it is devastating for me. It is too much. Too much internal pain. Most of us soles alzheimers with the elderly but martha is not even 50 years old. Hers is early onset alzheimers and it is hereditary. Which is one reason we come to medellin. My grandma died from it, they say she went still litigate. Not, not her grand marks her mom. Oh, yes, my mom, my mom. Alzheimers is devastating at any age. But particularly for those with hereditary early onset, which could account for up to five percent of patients worldwide. Yet as you will soon see, marthas extended family may hold the key to treatment for alzheimers everywhere. Lets start with stretching our hands up. Alzheimers is already a Global Health crisis affecting one in eight americans over 65 and one in two over 85. Thats one of the most common causes of death in the United States. Dr. Eric ryan man of phoenixes Alzheimers Institute says by the year 25th the United States will have about 16 million alzheimers patients at a cost of 1 trillion annually. Because the number of People Living to older ages is rapidly growing, we think that the single age related disorder will take a financially overwhelming toll on us all by the time my children become senior citizens. Still, there may be reason for optimism. It has been shown that the degree of brightness you have on the scans is highly associated with the numbers of plaques you have in the brain. Using advanced Imaging Technology he is able to point out the beta and plaque, a buildup of protein in the brain of a living alzheimers patient. Most scientists believe the protein is a main cause of alzheimers. Before this scan, how would we detect the presence of the analoid plaque . Well the best way was as autopsy which obviously is too late for the patient. But while alzheimers can be more accurately diagnosed, a cure remains elusive. Thats because by the time even mild symptoms appear, brain cells are already badly damaged by the plaque, the brain has literally begun shrinking. We can see these alzheimers plaques building up in patients brains 15 to 20 years before they likely would have any symptoms. But what if you had a group of people you knew would develop alzheimers and you could shoot them years before their brains were damaged at all . If the disease were prevented this people otherwise fated to get it, that might lead to treatments for alzheimers patients worldwide. Which is where martha comes in. Her extended family in medellin and the mountainous country side around it are carriers of a rare genetic mutation that guarantees they will get early onset alzheimers. With symptoms developing this their 40s and progressing to death just a decade later. This genetic mutation is so rare that only a handful of families around the world are known to have it. Marthas extended family is one of the best documented. At, the first patient i saw was approximately 49 years old and had complete memory loss. It was remarkable to me that his father had the same illness, and his grandfather too. This was my First Experience with hereditary alzheimers. Dr. Francisco loquero is director of the Neuroscience Group in medellin. Since the early 1980s he has been studying marthas family. Of an estimated 5,000 members, about onethird carry the mutation. Some Family Members believed that the disease they have lived with for generations was a hex. Some of the Family Members believed that the illness was caused by a curse that a priest put on their town. It took a while to gain their trust but today the doctors team has collected the dna of over 3,300 Family Members, 300 of them are participating in one of the worlds first drug trials aimed at preventing alzheimers. We are very optimistic about this. The medication has neve never bn tried on healthy people. The universitys brain bank includes 75 brains of Family Members who died from early onset. You knew many of those people. Si. Both of them. Most of them. I know most of them because i was during neurological examination. The ravages of the disease weigh on the minds of younger Family Members like natasha, martha and joses daughter. There is a 50 percent chance that she carries the mutation. What scares me in the future, not only for me but also if i am going to have children if it will affect them. Natasha says while she has given doctors a dna sample i prefer not to know. I dont get it. No. I prefer not to know because i will end up thinking about the future before i have to. In that case, i will always be thinking, oh, i will die of alzheimers, so, therefore, i prefer that they do not tell me. A breakthrough cant come soon enough for natasha or for another Family Member mauricio who lives in the small Village North of medellin. His mother in her fifties was in the final stages of her illness when we visited. I bathe her, yes, i bathe her. I dress her, i feed her. I do everything. Are you in school . Not right now. He says he left school at 13 to take care of her. Yes, i always wear myself out. They told me i look tired. Right now, yes, i always feel exhausted. I ask him what he would like to do with his life. I would like to sing. I like computers. I would like to study computers and become a professional in that. But he says he doesnt have time to think about the future or whether he himself carries the alzheimers gene. I dont care about what comes next. I am only thinking amount what is happening now. Last december, patients in dr. Ryan man and la parras study received their first dose office an experimental plaque reducing medication, a small but potentially important step on the journey toward a treatment for alzheimers. As members, do members of this family realize what position they are in and how much hope they are giving to alzheimers patients all over the world . Yes, they are more and more aware of that. They know that the study can serve many people in the world. They know that they have the possibility and opportunity to make a contribution to the world. Ahead, the man behind the mask. E in alaska are working to safely produce more energy. And now a page from our sunday morning almanac. April 13th, 1570, 444 years ago. Generally accepted birthday of the english conspirator guy talks. Talks. Although his father held a job with the church of england, he was catholics were persecuted, he served for a time in the army in catholic spain, under guido, he returned to england and he joined the catholic plot to place gunpowder under the houses of parliament and blow them up. But early in the morning of november 5th, 1605, fawkes and the gunpowder were discovered, king james took a personal interest in his case and in the words of his director the gentler tortures are to be used first against him and so by degrees proceeding to the worst. In days guido signed a confession revealing the names of his coconspirators. He and his company were executed early the next year. And ever since britain has celebrated the filing of the plot with fireworks and bond fires, bonn fires, as for fawkes he is all sort of allpurpose symbol of insurrection most vividly in the film v for vendetta, wherein the leader of a revolt against a future totalitarian regime hides his identity behind a stylized guy fawkes mask. People should not be afraid of their government. Governments should be afraid of the people. The mask is adopted more recently still by protesters of all sorts, venezuela, to washington, to wall street and more. Remember the fifth of november, gunpowder treason and plots, a popular rhyme begins, and with guy fawkes the plots recognizable front man there is no likelihood of it being forgotten any time soon. Osgood coming up, new from the top. This portion of sunday morning is sponsored by advil, the pain reliever that is built to be as fast as it is strong. Osgood legos are more than a toy for the world famous architect sofi he is the inspiration for one of his most famous works, Martha Teichner has the portrait of an artist on top of the world. The man in the pool is architect moshi softi a man of the world at the top of the world, the creator of this colossal stonehenge, the 10 million square foot marina sands resort that dominates the singapore skyline. 57 stories up, 650 feet off the ground, there is a park and a pool that seems to spill right over the edge. I didnt know what it would be like to be on the 57th floor, would it be too windy, how would it feel . Would you feel vertigo. He is building or has completed 85 projects across five continents. Museums, colleges, apartment complexes, libraries, government buildings, airports, an entire town. Global citizen is the name of a recent exhibition of his work at the Cultural Center in los angeles which he designed. The circumstances of life made me a man of many countries and many places. I have three citizen ships, israel by birth, canada by adoption, and the United States by adoption, so i have three passports. Born in 1938, he spent his childhood in hyfha on the mediterranean coast but his family moved to Montreal Canada when he was a teenager and Aptitude Test in high school led him to study architecture at macgill university, he had no idea that his thesis, a concept for reinventing the Apartment Building would soon make him world famous. It became habitat 67, the center piece of canadas worlds fair, expo 67. I was then 24. It was like a fairy tale. The point was to create a better way to live in a city. Affordable apartments that were not cells. They were more like houses, accessible to nature. Each of these boxes is preface indicated, prefabricated in a factory we built, we have kitchens and everything in the factory, lifted each box by crane and lifted them one on top of the other. He admits being inspired by legos. Each apartment which is made up of two or three or four of these boxes has one or two recesses one above the other on the way up. 15 million fair goers saw habitat, it became an international sensation, so did mosha softi and suddenly there were plans for habitats in new york city, jerusalem, in puerto rico, but none of them ever got built, a huge disappointment for softi. It is ahead of his time then and it is ahead of the time now. It is a time yet to come, still i say that. Because . Because i think it is meanwhile, from the moment habitat was completed there were waiting lists for its 158 apartments, there still are. It is really pretty. She moved in with her family in 1973. It is a house, yet it is an apartment. Moshe has moved on but has taken with him many of the ideas he explored here. He says that as an architect he uses light and water to try and achieve what music achieves with rhythm and melody. I have always wondered, can architecture actually have that kind of impact that music has on us . Because that is beyond utility and beyond functional. It is spirituality. The pavilions of crystal bridges museum of american art in bentonville, arkansas are actual bridges built over a flowing spring. At israels Holocaust Memorial and museum in jerusalem softi built through a mountain. I felt that the story of the holocaust is so horrific it cant be a building that feels like a building, so i thought, i started thinking underground. Introspective. Yes, completely, you go deep into the earth and then you emerge to life at the other end of the mountain. That was controversial because people said it is overly optimistic why are you doing that . Zero why so he expressive and my thought is, life prevailed. The nature of his commissions often requires turning symbolism into structure. I wanted to be drenched with daylight and many of my buildings, here, because light penetrating the building has something to do with peace for me, it has something to do with transparency. The United States institute of peace in washington, d. C. Is meant to suggest the flight of a dove. Was it important to you to do good with architecture . Every project, the sublime and the ordinary has Critical Issues of humanity, of social responsibility, it could be a housing project, it could be an institute of peace, it could be the Central Library of a city. Humanity and social responsibility, why more is that softi is still refining, revisiting habitat 67. This is and at his office in an Old Industrial building outside of boston, the drawings and models show how he has adapted his ideas for humanizing city living. The shape of the facade is undulated so each unit has a garden coming out of it right there as you clim