From nbc news World Headquarters in new york, this is nbc nightly news with lester holt. Good evening. We begin with a heartbreaking story out of oklahoma where a College Softball team trip ended in tragedy on a busy interstate. Four young women were killed after the bus they were on collided with an 18wheeler. All the victims were members of the Softball Team at North Central texas college. The youngest of those killed was 18, the oldest 20. And tonight back in texas their tightknit College Community is gripped by a profound sadness. Kerry sanders is in ardmore, oklahoma, tonight for us. Kerry, good evening. Reporter good evening, lester. The womens Softball Team was about 40 miles shy of their destination when their bus was hit by a tractortrailer that crossed that wide grassy median down there here on interstate 35. The crash happened on a stretch of interstate 35 in oklahoma where the speed limit is 70 miles per hour. A tractortrailer headed north, a College Teams bus driving south back to texas. Those who happened upon the wreckage in the dark describe chaos. This girl, she was in her seat and the bus came on top of her, on top of her head. Reporter killed in the accident four players on North Central texas College Softball team. Freshman infielder katelyn woodly and three of her sophomore teammates. Pitcher meagan richardson, jaden pelton, infielder brook deckard. I would like to offer my sincere condolences to these families. Reporter the lady lions had just scrimmaged against southern nazareen university. You just picture the faces you just played. You cant imagine them actually being gone. It wasnt real. Reporter washingtonbased investigators from the National Transportation safety board are now here trying to determine why the truck drifted over the rumble strips, into the grassy median and headon into southbound traffic. This afternoon wrecker crews were still cleaning up finding personal items including a cell phone. And in the brush alongside the road, practice softballs. One of them girls that died touched one of these balls. Touched one of them. Reporter this evening friends and family have gathered in gainesville, texas, to remember one of the victims. Most of the injured players have now been released from the hospital. First responders tell nbc news some of those survivors had to be cut from the wreckage learning as they were saved other teammates had died. Among the things the ntsb is looking at, why is there no barrier in this section of the highway where a few miles away there are steel cables that may have prevented this accident. The truck driver survived this accident. The truck tonight, the oklahoma Highway Patrol says theyre categorizing this as a homicide investigation. Lester. Kerry sanders tonight. Thank you. The countrys air travel system began to recover today. Flights resuming at chicagos two airports after a big Regional Air Traffic Control Center was knocked out by an act of sabotage. Still, more than 700 flights were canceled at ohare and midway. Much of the air traffic normally handled by the damaged facility in aurora, illinois, was handed off to other facilities. An employee allegedly set a fire at the Aurora Center then tried to take his own life. Federal Health Officials are monitoring nine children in colorado tonight with symptoms that range from muscle weakness to paralysis. And at least four of them have tested positive for a rare virus strain thats caused severe respiratory illness of hundreds of kids around the country. Nbcs Hallie Jackson has more tonight on this new health alert. Reporter Jaden Broadway could barely breathe, so his mom knew he needed help, fast. I was across the room and i could hear him wheezing and it was petrifying. Reporter the 9yearold who has asthma showed symptoms of enterovirus 68 and was treated earlier this month. Now four children in colorado who tested positive for that strain of virus are showing poliolike symptoms. Health officials are trying to determine if theres a link. Some of these kids i think are just having some weakness and some have progressed to paralysis. Reporter doctors say the paralysis could be an extreme complication of a virus that typically develops like a very bad cold. Across the country the cdc says 277 people in 40 states have tested positive for enterovirus 68. Virtually all of them children. Parents have been warned to watch for symptoms in their kids like extreme trouble breathing, severe coughing and sometimes wheezing, fever and a rash. Outside Los Angeles Erin noticed her son struggling with similar respiratory problems two years ago, before he was paralyzed. She says her toddler was never tested for enterovirus 68 but was diagnosed with a poliolike syndrome. So after hearing about the cases in colorado, she felt for those families. I know this dark hole that they are facing not knowing where to go, what to do. Reporter the cdc wants doctors nationwide to report any clusters of kids with breathing problems and muscle weakness or paralysis. All in the fight to figure out this dangerous outbreak that has doctors and parents on edge. Hallie jackson, nbc news, los angeles. Overseas the u. S. And its allies conducted more Bombing Missions today against isis targets both in syria and iraq. But after weeks of bombing in northern iraq, the campaign seems to be having little effect. Nbcs bill neely is there for us again tonight. Reporter british jets join the air war against isis in iraq. The coalition and its fire power is growing. American warplanes make up the bulk of the force bombing iraq for more than six weeks now. More than 220 air strikes by u. S. , european and arab states hitting isis targets. They aim to degrade and destroy the group. On the ground, kurdish troops show me where the most recent american bombs hit destroying armored vehicles. But in an isiscontrolled village their black flag still flies. The isis positions here and just over there, theyre on two sides, havent moved in spite of four days of air strikes. The u. S. Warplanes are hitting isis vehicles, but the islamist fighters arent leaving. Air power has its limits. Isis gunmen on this front line hold ground and stand guard without fear. Their fighters have beheaded americans. So far u. S. Fire power has not cut their lifeline. These are the Ground Troops the u. S. Hopes can retake land after air strikes, but they are outgunned by isis. Their heavy weapons are old. Their Missile Systems outdated. New weapons are promised, but havent reached the battle. This kurdish commander says without better weapons they cant attack isis. So for now a long entrenched front line is growing with both sides dug in. The u. S. Has warned this war may last for years. Air strikes can degrade isis, but air power alone cant win it. Bill neely, nbc news, kurkuk, iraq. In japan at least one person is dead tonight, Dozens Injured and many still stranded on a mountain after a volcano suddenly came to life. We got the latest tonight from nbcs kelly cobiella. Reporter mount ontake came to life with a boom, a witness said it sounded like thunder, then everything went dark. Hot gas, ash and rock shot two miles into the sky at midday with no warning. This cell phone video captured the frantic moments after the eruption. The volcano is a popular spot for hikers and more than 200 were climbing the slopes today. Within seconds these hikers were covered in ash. One woman was killed and more than 30 seriously injured. Many by flying rocks. Mount ontake is 125 miles west of tokyo. The last major eruption in 1979 covered the area in 200,000 tons of ash. Today, rock and ash rained down across two and a half miles, causing a few flight delays but no Major Airline disruptions. The ash is a problem for rescue helicopters. Searchers have to climb the mountain to reach survivors. Japanese Prime Minister shinzo abe said the army will help evacuate as many as 150 survivors still stranded in lodges. With the volcano still active, rescuers have to wait until daybreak to reach them. Kelly cobiella, nbc news, london. Big news from the Clinton Family. A new arrival as chelsea clinton, a former member of our nbc family, gave birth to her first child and her parents finally got to call themselves grandma and grandpa. As speculation grows about a Hillary Clinton run for the presidency, todays news could have a big impact. We get more on that tonight from nbcs kristen welker. Reporter its a girl. Today the entire Clinton Family tweeted out photos of their new addition. Charlotte clinton mezvinsky. Hillary writing, bill and i are over the moon to be grandparents. And mom chelsea tweeting at 7 03 p. M. On september 26th we finally met charlotte. Were in love. Chelsea clinton has been world famous since she was about 12 years old. So its almost like the British Royal family. Reporter for the past several weeks the expectant grandparents have been brimming with excitement. First and most importantly, bill and i are on constant grandchild watch. Reporter historian Michael Beschloss tweeted out photos of past president s and their grandchildren from fdr, truman and lbj and saying being a grandparent can help politicians of both parties connect to voters on the campaign trail. I think that allows Hillary Clinton to say even more ive been first lady, i was a senator, i was secretary of state, but like you im a grandparent too. Reporter the image of hillary as a grandmother in waiting was first on display in april when chelsea announced she was expecting. I just hope i will be as good a mom to my child and hopefully children as my mom was to me. Reporter political analysts say clinton will likely consider her new role im back reporter as she weighs whether shell run for president in 2016. Theres no question but that shell take into consideration the fact that her daughter now has a daughter in terms of her deciding how much time she wants to spend in public life versus private. Reporter for now the clintons are celebrating the newest member of their family and publicly sharing the moment as hillary ponders what her next role will be. Kristen welker, nbc news, washington. James traficant jr. Has died. A colorful nineterm democratic congressman from ohio, an advocate for the disenfranchise and known for antics on the house floor. His speeches often ending with a nod to star trek and the words beam me up and known for his wardrobe including denim and polyester suits. Skinny ties and cowboy boots. He was expelled from congress in 2002 after he was convicted of taking bribes and kickbacks. He died after an accident on a tractor earlier this week. James traficant was 73. When nbc nightly news continues on this saturday, bumper crop as legalized pot fuels a new breed of startups looking to cashin. And later the memories of a Country Music legend. Thousands of his personal items from a road well traveled now about to be sold. Were back tonight with a sign of the times. High times in colorado, where business has been booming since Recreational Marijuana use was legalized earlier this year. This weekend those behind a new wave of potrelated Tech Startups are meeting at a conference in denver looking at green in more ways than one. My report tonight from nbcs gabe gutierrez. Reporter as the smoke begins to clear from colorados social experiment, the ideas here are bigger than the bong hits. So weve been growing at a rate of 25 . Grow buddy has a grow journaling app. I built the courses to be extremely interactive. Reporter this is billed as the first marijuana tech startup competition ever. Entrepreneurs hoping their pot pitches will turn denver into the next silicon valley. You can be young and be a boss and nobody disregards your age. Reporter this 25yearold is aiming high. He says he turned down a job at a Tobacco Company to start a webbased destination connecting marijuana buyers and wholesalers. All he needs is the technical help to make it happen. You hope to develop the Chicago Mercantile Exchange of weed. In due time, yes. Reporter one investment grum here is only focusing on potrelated startups and has already shelled out more than 12 million. It predicts the budding industry will grow to more than 10 billion by 2018. This is a big deal because its really people shining a professional spotlight on the innovation that can be seen applied to the cannabis industry. Which before has not been able to be done. We got this building about two months ago. Reporter zack just moved here from indiana. His Company Already employs five people who create smartphone apps. One is a dating app for pot smokers. Another allows users to research and discover dispensaries. Im sure people are surprised were not smoking a bong right now. Contrary to belief were able to get work done and build a business. Reporter so he coorganized this weekends event. Smokings allowed in a private area. But more focused on meeting developers and investors to get his business off the ground. So it relies on a product still illegal in most states. With great risk comes great reward. Reporter and has the green rush going hightech and a new generation of entrepreneurs fired up. Gabe gutierrez, nbc news, denver. Theres more to tell you about. Up next, what some are calling the wedding of the year. The scene here in new york this evening live from central park where tens of thousands have gathered for a starstudded concert. Its this years Global Citizen festival. And for the most part it was an invitation event. Most of the fans were given tickets because theyve taken action to help end world poverty. And tonight we hear from some who are doing their part in their own words. My name is deviny james. I teach at outdoor nursery school, which is just outside washington, d. C. I grew up on the Beautiful Island of jamaica. I am the first one out of my family to graduate high school and to go to college. My vision is to educate all girls worldwide. I was looking through my purse and i saw all of these pennies. And i thought what can i use them to do. So far i have collected over 600,000 pennies, 60 alone could send a girl to school for the entire year. Im steve crane, age 72. I live in seattle. And im a member of the seattle rotary club. I was diagnosed with polio at almost exactly the same time as the vaccine first came out. I did not have the benefit. It would have made an enormous difference in my life. I was a star athlete. I couldnt make touchdowns and score and do the things i like to do. My mission is to help fund the eradication of polio by urging members of congress to provide the critical funding in order to finish the job. And were this close. My name is sarah. Im 15 years old and im a sophomore and i go to Aurora Central Catholic High School in aurora, illinois. When i was in elementary school, my mom had lost her job at the hospital she was working at. So our family was struggling for a bit. Our town opened a local food pantry. You can have three items today. Now instead of being in the line for the food pantry, im volunteering and helping at the food pantry too. At the Global Citizen festival, every person there is there for the same reason that i am. Just try to end global poverty. And thats what makes me smile. Thats what im looking forward to the most. You can watch an hourlong primetime special on the festival right here on nbc tonight at 9 00, 8 00 central time. In venice, italy, tonight the wedding some thought would never happen Actor George Clooney tying the knot with amal alamuddin, a human rights lawyer, he is 53, she is 36. It all took place at a sevenstar hotel. It was called the grand canal. So many celebrities descended on the city that one headline called it hollywood on the adriatic. An official civil ceremony will take place on monday. When we come back, up for sale some of the prize possessions of a Country Music legend. Finally tonight, were getting a rare glimpse into the life and times of one of the superstars of Country Music, the late Waylon Jennings has spent years on the road. And along the way accumulated a treasuretrove of objects. Next weekend thousands of them will be auctioned off in arizona. Our report tonight from nbcs kevin tibbles. Reporter they called him an outlaw. I never could tow the mark and never could draw the line reporter but those who knew Waylon Jennings like his wife, jessie colter, call him the real deal. He was a peoples choice. He was a man of the people. People were comfortable. And if you werent comfortable, hed make you comfortable. Reporter jennings who died in 2002 dragged traditional Country Music kicking and screaming into a marriage with rock and roll. He was an outlaw in the sense he didnt conform to the establishment. And people could read into that anything they wished to read into it. Reporter it was all those years living on the road that perhaps took Waylon Jennings from his fans at the relatively young age of 64. Jessie colter is now auctioning many of their shared possessions, in part to raise money for the phoenix childrens hospital. It was an easy choice. Waylon would say if i cant figure out who i am, i look to a child. When i want to see who i am. And thats a pretty co