As Martha Teichner will report in our cover story. Calliope joy carr age 6, is slowly dying of a rare genetic disorder. Giovanni price, also 6, has the same disease. But look, he could be any normal first grader. He doesnt know the miracle that he is. And he doesnt know hes not supposed to be running and jumping and playing. That miracle and the future morning. Pauley phil collins is a music superstar who glow has dimmed somewhat in recent years. This morning he talks candidly with our jim axelrod for the record. . The songs the same, but the singer, well, thats a different story. The spotlight, and bearing his soul. I got five kids, you know, and until recently i havent lived with any of them. And that, you know, thats a personal thing that i have to deal with. A very different side of the superstar later on sunday morning. Pauley now you see them, soon you wont. Conor knighton is on the trail of the sha ripping glaciers at the tripod is carefully positioned. The framing has to be just right. When dan fagre is replicating old pictures he makes sure everything is exactly the same. To show just how much has changed. I consider myself a scientific pap pap for the glaciers. Scientists have focused on these Montana Mountains as a poster child for Climate Change. National park loses all of its glaciers . Ahead on sunday morning. Pauley when it comes to fine print, the lawyer turned author john grisham has fewer pierce. His enthusiasm for his craft still shines brightly as Anthony Mason found out during a recent visit. Do you still get excited to see the hard cover arrive . Sure. Every time. He sold nearly 300 million books, gut gone grishams legal thrillers dont always get respect. In the early days rightly irritating. Makes you hate critics. This is your first dual number one . Hes been rewarded in other ways with 28 consecutive number one best sellers. John grisham, later on sunday morning. Pauley lee cowan takes us to ma magic and colorful york times columnist, maureen dowd. Faith salie puts in a good word for swearing. And more. First, here are the headlines for this sunday morning the 23rd of october, 2016. Its a multimedia mega deal. At t is buying time warner, owners of the Warner Brothers studio, cnn and hbo and more. For some 85 billion. At t, as you knows a phone provider and also owns directv. The deal faces still scrutiny from regulators. Defense secretary ash carter is in irbil, iraq, this morning. Carter arrived for an unannounced visit yesterday and met with the Prime Minister to discuss the offensive to retake mosul. Americans are supporting the mission with airstrikes and advisors on the ground. Isis has held the city since at a Campaign Appearance in pennsylvania, donald trump said yesterday he will sue the women accusing him of sexual he misconduct. An 11th woman is now speaking out publicly. A member of the Swedish Academy awarded bob dylan the nobel prize in literature is calling his silence sis receiving the honor i am polite and arrogant. No comment from dylan. Surprise. To their loy but now the chicago cubs are winners, capturing their first pennant since 1945 after beating the l. A. Dodgers last night 50 in game six of the nlcs. They play the cleveland endians in the world series starting tuesday. Stay tuned. Now todays weather. A pleasant fall day is in store for much of the country. Not so in the northeast, though, cool. Rain and even snow cant be ruled out. Showers will also dampen the pacific northwest. In the week ahead, hot and sunny in the southwest. Elsewhere, time to grab a jacket. Next, how hiv helped give him a new lease on life, later they lookmo ,,, pauley the genetic legacy each of us inherits is a powerful force. In a few extreme cases, it can even be deadly. Still, thanks to genetics need not always be destiny. As Martha Teichner shows us in our cover story. Amy and brad prices home in omaha, nebraska, is crazy with all the kids around. There are seven of them ages 2 to 11. But if you look closely youll see small memorials to one more. A rare nightmare disease called late infantile metachromatic leukodystrophy. Mld. That destroys brain cells and is caused by a single, faulty gene. She was happy all the time. She loved pretty dresses. Or a tutu. Always had on tutus. She was talkative, addicted to caillou the series. A lively little girl until she was two. Her knees were going a little knockkneed and she had been just randomly falling down. Her doctor said, nothing to worry about, but she quickly got worse. I was in the kitchen doing something i heard her crying. I turned around i said, whats wrong . Mommy, my legs dont work. Liviana was diagnosed in the fall of 2010. Theyre telling me shes going to die. These are faces of mld. Many children with the disorder are dead by the age of 6. And it runs in families. If it hadnt been for liviana, amy and brad price would never have known to have their other children tested. They learned that their infant son, giovanni had inherited the faulty gene, too. Office. Did you just know . I knew. I was thinking, ive really have just been told two of my kids now are going to die. Except thats not what happened. Doing research online, amy price discovered the existence of a medical trial in milan, italy. Is of an extraordinary gene therapy treatment for mld that later when his sister, cecilia, was born with mld. Hers, too, the treatment works only only children who like them have not yet started showing symptoms. Dr. Alessandra biffi over saw the trial. The patients go to the surgery room for collection of the stem cells on monday and receive their cells back on friday. A patients stem cells contain the faulty gene. Which the doctors have learned how to fix. Amazing, right n then they need a vehicle to insert the good gene into the stem cells before those are put back into the patients body. Heres whats really amazing. That vehicles is the hiv virus, reengineered so the children cant get aids. Why the hiv virus . Is it particularly efficient . Yeah. Very efficient in entering our cells, thats why we use it. How well did the children do . It will take years to know for sure. But so far, so good. At least 7080 of them have an outstanding benefit coming from the treatment. Some of the treated children were going to school and having a normal life. Look at giovanni price, six now. In first grade. Look at his for short. Twice a year they have to go back to milan to be tested and mob stored. Tell me about dr. Biffi . Oh, gosh. I call her my angel. Our angel. She took us in like family. So why italy not the United States . Gene therapy has a checkered withered after serious setbacks, including a death during clinical trials. You see all that typical virus but more than 15 years later its back. One sign, dr. Biffi is now head of the Gene Therapy Program at dana farber boston Childrens Cancer and Blood Disorders center. Do you believe that gene therapy is finally coming into i think, yes, absolutely. The mld trial biffi thinks demonstrates whats possible. Offering promise to the 30 million americans who suffer from some 7,000 rare diseases. Trials for the experimental treatment ceci and giovanni price received in milan have not begun in the United States. They are two of only 24 children it. Doing pretty good out there, dub bee. Compare giovanni start your spa treatment. To calliope joy carr also sixf bala cynwyd, pennsylvania, outside philadelphia. She can turn her head a little. She can still smile and laugh. But she was diagnosed at two. For her parents, College Professors patrick carr and maria kefalis coming to the terms with the disease was wrenching. The time is in slow motion. The social worker said, its good to try to cry in the shower your children. After more than a year of rage and grief, maria decided that she had to find some way of helping mld children. It was too late for cal, but she was desperate to give her daughters life meaning. Were not wealthy people. We dont know very influential people who could write a big check for a million dollars. Well start selling was formed in 2013. Its been slow going, but the money added up. And when maria learned about the italian trial and the fact that amy price had to keep going back to milan with giovanni and ceci it was clear she would use the money to help families get to italy. She sent me a picture of hes three months younger than cal. He should be on feeding tube, paralyzed. I thought, i got to be a part of this. I need to help this happen again and again. Maria kefalis has turned cupcakes into weapons of war. Her war against mld. Seems silly, but i dont know what else to do. Shes raised more than 25 but shes hit a wall. So far not a single gene replacement therapy has been approved by the f. D. A. Trial in italy is closed to new patients. It could be years before any children with mld will be allowed to receive the treatment in the United States. Now its just impatients. Now its like, when do we get this here . Tell me what you need me to do. Yeah, cupcakes one cupcake at a time. The price children, proof to her that the war can be won. You keep using the word miracle. In what way is all of this a miracle . Our sons still with us. Thats the miracle. And cecilia as well. Pauley ahd, with ingredients like roasted hazelnuts and cocoa, nutella adds a smile to any morning. Nutella spread the happy but theres so much more to it. Heres how benefiber . Works. Inside us are trillions of good microflora that support digestive health. The prebiotic fiber in benefiber . Nourishes them. And what helps them, helps you. Pauley and now a page from our sunday morning almanac can october 23, 1814. 202 years ago today, the day london doctor Joseph Carpue performed what is widely regarded as the western worlds first modern Plastic Surgery opern. Plastic surgery was long practiced in india, where dr. Carpue observed it firsthand. His subsequent successful operations, and his writings about them, caught the attention of the medical world. Fast forward to today, when Plastic Surgery figures prominently in tabloid speculation about any number of hollywood stars. Plastic surgery has even played like nip, tuck. I need a bigger set of torpedoes to give myself competitive glenn you want breast implants. Popular as Plastic Surgery is here in the United States is even more popular in beachbody minded brazil, as cbs news discovered during a visit in 2005. Tall, tan, young and lovely as she is, shes getting a little extra help these days. Right afte the clinic, i felt different already. Something like, okay, people are looking now. I like it. Pauley when it comes Plastic Surgery all is not vanity. According to the American Society of plastic surgeons the number of americans who had cosmetic surgery last year was about 1. 7 million. But more than three times as medical reasons. . Fifty years ago, humpback whales were nearly extinct. They rebounded because a decision was made to protect them. Making the right decisions today for your longterm and preserve your legacy. Ask a Financial Advisor how retirement and Life Insurance solutions from pacific life . Before it became a medicine, it was an idea. A wild whatif. So scientists went to work. They examined 87 different protein structures and worked for 12 long years. And the hope of millions. And so after it became a medicine, someone who couldnt be cured, could be. Me. . That was a great it. You must it. What . Is he gone . . Finally, i thought hed never leave. Tv character why are you texting my man at 2 a. M. . No. If you want someone to leave you alone, you pretend like youre sleeping. Its what you do. If you want to save fifteen percent or more on car insurance, you switch to geico. Pauley a range of mountains appeared like magic in americas Western Desert a few months back. The peaks have attracted any number of visitors, including our own lee cowan. I15 in nevada just outside las vegas, arguably one of the more bland stretches of pavement on the planet. But out in all that khaki is something that has motorists rubbing their eyes in disbel this is no mirage. Its very real, very big and very bright. It does sort of call to you from the road in 5 way that nothing else in the middle of the desert necessarily does. Made of painted limestone, these technicolor towers appear both ancient and modern, both native and foreign. That is precisely why it is art museum of art. I think were seeing a movement over the last few years, where artists would like to engage a larger public and would like to have scale. They look almost like people, just giant, nice people, gentle people. Its the vision of uro rondinone a swiss artist living in harlem who calls his desert friends the 7 magic mountains. What do you want people to take its not something intellectual, just something to experience. I always say you dont have to understand an artwork. You have to feel it. And. And people have been making connections with it ever since ugo unveiled it this past may. Its so colorful, its huge. Its not something youd expect to see out here in the desert. Its real surprising. Droves of the curious have been braving the desert heat, investigate the oddity for themselves. One, two, three. Its a social media magnet. Cool, huh . A backdrop for all manner of things, both real and a little surreal. Like the costumed aliens who showed up when we were there. Still, the work is not for everyone. There are some people who say that its marred the desert, not big fans of it. What do you say to those people . People who have never experienced the landscape, the nevada desert, for the first time when they come with their children they see the beauty of this landscape. He took the boulders from the landscape itself. Each he hand pick fred a nearby quarry, some weighing more than 50,000 pounds apiece. We moved them stone by stone. One by one. Saw. And holes were drilled for an internal skeleton that would hold the boulders in place. And then came layer after layer of that bright dayglo paint. Its the contrast that you wanted. Between the artificial and the natural. Exactly. I tweeted use natural materials but make it artificial. Its its worth coming down here for. Thank you. Bigger than i thgh its size is historic. Its the largest land art project out here in more than 40 years. Michael heizer made rift, a zigzag trench dug in a dry lake bed here in nevada back in 1968. Two years later, the spiral jetty, was envisioned by robert smithson, since then, nothing has been created on that kind of scale. The Nevada Museum of art wanted to reprise that tradition, ugos art would get the maximum number of eyeballs from people people going to and from las vegas. Its just a very small percentage of people to go a museum or a gallery. So i love the idea of public art and having it in the open for everyone to see it. Its not forever, however. In two years, 7 magic mountains, is scheduled to be dismantled. The is sentinel, isha beckoned the curious from the freeway will remain only in the minds eye. You financed one of your films. Lets not talk about that one. Pauley still to come, author john grisham holds court with Anthony Mason. Collins, back from deaths door. , ,, pauley 1993s the pelican brief with Julia Roberts and Denzel Washington was a hit film based on just one of the highly successful novels by john grisham. Hes written enough fine print to fill a large book case, not to mention furnish a whole office as Anthony Mason discovered. These two desks were these were in the film. John grishams offic props from the films made from his legal thrillers. And the door . That was sues sa san sarandos law office in the client. Whens your boss coming back . Why, may i ask . The client is the story of a lawyer. Im reggie love. Played by Susan Sarandon in the 199 film, she represents a boy who may know where the body of a murdered u. S. Senator is then just keep our fingers crossed. First we got to be sure the bodys even there, right . Suspense like this has helped grisham sell nearly 300 million books. Do you still get excited to see the hard cover arrive . Sure. Every time. These came in two days ago. The whistler the sale of a corrupt judge and an indian casino is the latest thriller for the author, whos had 28 consecutive number one new york back too to the pelican brief in 1992. Heres the cool stuff, foreign ed glick how many countries are you published in. Up to 48 or 49 language isz its been quite a journey for Johnny Grisham junior as he was called in south haven high in mississippi. The son of a cotton farmer, grisham would get his law degree from ole miss. This is your First Business card . Yes. My Little Office in south haven, mississippi, on state line road. I had a hard time saying no to people in trouble. I really had a hard time. Just because folks needed help. When you do that as a young lawyer its hard to make a buck. To make an extra buck, grisham started writing. Why did you think you could do i didnt know if i could do it. I knew i was going to try. I used to walk in a book store reich this see all of these books on the walls i would say, who wants to hear from what do i have to add to all this. Where did that bug come from . You hadnt really been writing before. I had never written anything. I had never studied writing. I had a great story. Simple as the story. Time to kill. It would take him three years during which time he was also serving in the Mississippi State legislature. Were you a good legislator . I was terrible. I had the highest absentee rate of any freshman legislator. I got sick of the job. I wrote of a lot of a time to kill at the State Capitol in jackson, mississippi, hiding in Little Committee rooms killing tim