A nico is in germany to learn german lunch pinnacle. Why not learn with him online, on your mobile and free chest c, w e learning course eco speak. Ah ah. The 1st questions appear as quickly as the cancer. What are my chances . How much time do i have . Medical advances . Mean half of all Cancer Patients can be cured. But those, this report cant be cute. Their only hope, cutting edge cancer drugs, many promise a longer and better life with cancer. And as ive, the exclusion of new medications is a blessing for many patients of the islands. But many drugs do little and escape true evaluation of dental and gain. Many patients have just one choice. Try them and hump oh, im ready comment though. If were honest to the guns. Ellison, we dont know if a drug will work. Informa, why has communist i embark . You cant get a word out. Its like being trapped in your body. Of that, i wouldnt wish that on any one of us on me, and i would never have linked these side effects to this drunken to comment about how safe and effective are these new cancer drugs. How well are they researched before theyre released, then, or is it worth you and us via the money average long were seeing more drugs being fast tracked as a child with less and less certainty about their efficacy on, on his own. Were spending massive amount disregard all scheme 8600000000. 00 euros for cancer drugs each year and the trend is increasing. How effective are they . A marty and drink has had chronic leukemia since 2007, incurable. The disease is always present every day, even on vacations, photos of her last cruise hooked it as the man he had and did look at this. You mason, you are clean cortisone cheeks when it surprises me every time here. Its embarrassing, didnt evict me. Its not, its your life and my life to. Im also tooth athletic about cook my toilet even when i looked so awful. Look how you look at me on my way. Its wonderful. Thought haley adams again. They are. Her 1st serious symptoms appeared in 2013. 0, so she spent 6 months in hospital chemotherapy and high doses of caught his own, brought her cancer under control, but then it returned her rubbing her energy with oh my god. Yes he from london. But his head and it was so difficult just moving from the bed to do a bit of washing up and then back to mahonnan. Done with things like that. If you have to experience it yourself, man, woman, so this exhaustion never ending exhaustion longer does. It wouldnt english about was my experience, maurice surfaced but fear what would have happened if you hadnt received treatment, hickin, and vh thank flow of his gastorm. I would have died until appeared without treatment. How chronic lymphatic leukemia killed you . Logan made some porter with treatment. You can, what does my specialist say . You can grow old with an effective therapy, good, and flea. The chemotherapy wasnt effective just a few years ago, there would have been nothing more for patients like ring. But there are new cancer treatments. And there her hope. Then manzona ish earn, if you have a serious disease like i do me with very few drugs available, then youre trapped to you would are fold that in what you have to say at some point. I know i want to live with lee. I want to sobriety him, youre grateful there. And now so many drugs, speed seller, me to comment and switch and gift. Shes been representing patients for years on various committees. She knows the Health Care System for for them to send them to alicia. She knows that new and promising drugs are always being developed on dustins laws. Ah, modern cancer drugs are often the final attempt to extend the lives of people who have been curable, cancer, the hassle, her community hospital, berlin has allowed us to fill. Despite the pandemic, it has a unique humanist approach, an office state of the art cancer drugs in its certified oncology co units. Each morning, the pharmacies deliver cancer drugs customized for individual patients. In addition to chemotherapy, new immune and antibody therapies, potentially flock said mechanisms in cancer cells more precisely than key my therapy, oncologist on and mrc, has worked at the center for our patient chima treatment since 2017 you him number. And this is an antibody that we often combine with chemotherapy, young visa to antibodies for a Breast Cancer patient like a lock and key for a particular part of the cancer cells. These are some floss patterns and some of the new therapies cost many times more than classical chemotherapy and gorse. I give me the come into the a lot of these very expensive drugs and not designed to cure the patient. Idol author tilapia for they slow the disease of and ideally maintain quality of life when the relations can then remain independent, heightened, lapsed, and they also live longer would, as its vital effect in mouth and even filling up for oncologists like on a missing the range of Treatment Options gross every year. They are currently 237. 00 cancer drugs on the market. A good one, 3rd of which a state of the art cop tales that are recombined again and again for more and more cancer types. He tries to keep track of this market of hope. New marketing materials arrived almost every day. Your mother must been part of us. This is a combination therapy that was approved for prostate cancer. Was 50 percent. This is for female patients with a certain kind of Breast Cancer. You get to say 5 here. There are 2 combinations for patients with malignant melanoma home. And finally, an antibody combination for a specific leukemia hoops and anti copper papa doesnt. Thats 2 or 3 days worth of marketing material i the hog. Im sure all my colleagues receival this to but on the other man at the superlatives of pure marketing for the Quantum Leaps everywhere thing the things. And alice fontainebleau. We cant difficult is it for you to stay up to date does is not hipaa often as of yet not really to lot of workmen zuber you can do it yourself by reading journals. If not, thats a very important source of information without marketing of on babylon. Off either i dont have the time during my shifts to read up because even if needed side, that means i have to use my time off to stay up to date hinder here. And if i typed it in, the tuned us it, me dar by the skin formula to floss up on the cancer would an alarm, a patient in severe symptoms is getting worse. Cancer is very advanced for many patients on this wound in the fight to prolong life, freedom and shot, and his team always looked to the ideal dose and combination of active ingredients quickly with bad news for this patient. This last the count, if we know the liver is massively damaged, if her liver is deteriorating, repudiated, she knows it and wants to go to a hospice. Excellent. So when does cancer . When doth. And when can drugs ward off the victory for weeks or even months . Will the patient even respond to treatment . Difficult questions . It is. Oh, im ready comment, vert, when the guns, if were honest, we dont know if a drug will work in advance in for him on skipped a. M a respond. There are always responders and non responders in teams on behalf im forced back within the patient is told we have a suggestion guide. We recommend this treatment is regularly rises on sol as skipped off of likelihood that it will help is such and such. He does, if it was, he had a lot of people are afraid if theyre uncertain or, and doctor, we always try to offer the patient as much information as possible to make the decision all Time Favorite went off. We dont want them to refuse a treatment that could help him do it. Hows his this is the niche we work in law does faith of india. I let the mines em. Tennyson marian drink also has to research my things up, come to a decision. Ho. Leukemia had progressed and she had to rely on a new active ingredient a promising you combination therapy had been released about 4 years earlier. It was supposedly more effective than classical chemotherapy. If you really had no alternative to didnt typo nice 5 year, not then because we tried the traditional options. The common bush done. When i say we, i mean dr ludovic and die professor lute and nothing really worked and, and conceived nists voc leash bond patient is unclear. Nist on the thing. He carefully read all the studies he could about this drug or dish spite. I met old me again and again in the us there is something we can try. And kelley is that, maam, and an elderly man responded to it very well. I have a daughter mad bohannon and gloves or say a good on and you trust that and fat heart man. All her foolish, she decides to take the new drug. A bruton, it is an enzyme inhibitor that can very precisely slow down the growth of diseased blood cells. Study showed that 42. 6 percent of participants responded well to the drug. But after 2 weeks, something unexpected happened while on a short cruise. Im lets an on mac. It started on the last evening when i said, lets go to bed early. Im a bit cold and chivalry when we got up in the morning and wanted to leave the ship, i couldnt find my wedding ring finger so on. If i always take it off at night, usually i panicked. Reason panic, what was that . Wheres the wedding ring . Wheres the wedding ring . And i had to look for it. I see that it was on her other hand and, and then we left the ship and the situation with the bus made emboss. My mother with called my husband santa fe, comes the bus, get your tickets on me. I opened my wallet and tried to enter a pin game, said out, so my, instead of taking out her ticket over when dot you start thinking, oh, what is this as noon . She was also having trouble finding words or what renew it. Went on the canton. I wanted to tell a friend at our car about our vacation and have him i started to speak, but couldnt get a word out to the status of. I thought why its coming on here is what i couldnt get a single word out to her. Its like youre trapped inside your own body and you know what he want to thank back. Boy, i had the images i wanted to talk about, but nothing came out of the house. Ah, the next day she drove to work thinking the symptoms would disappear, but the opposite happened. She was rushed back to hospital and diagnosed with our trail, fibrillation, a transitory shaming attack or t. I a which it interfered with the blood flow in her brain. Ah, the doctor, treating her at the helios clinic in berlin bush noted. Oh, we diagnose our trio, fibrillation, and t. I a as an undesired side effect of a brute nib as it does a to yard id come years, all this tear, it came on. So suddenly and without warning, i there was no predicting it proceed. Ah, it took half a year to recover from the side effects. Was it a known risk . Ah, her oncologist, professor of t to load vig also chance the german medical associations drug commission. Thats what, what did you know about the drug command . We had no foul nose for fear yarn. When wilson does us, we had about 4 years of experience and knew that it had been highly effective with several patients who had already been treated with of the drugs or had really about us. I need a name, vocal, and keep the of a new a gun fire. We also knew that there was some rear side effects like arrhythmia with more strong and from diarrhea published thomas. And while i prescribed this drug, since i was quite convinced of its efficacy, because other patients had responded, manassas down as outside toyota, and for as a doctor says, you criticize yourself when its a patient with a disease she can live with for 10. I think 2030 years later vanish and then suffer severe toxicity to see that may have serious consequences. We have a photon and as these are toxicity, it had to have gone t i is not listed as a side effect in the 2014 clinical study. Why wasnt it discovered by the manufacturer . Theres man, many guys fired for less than 200 patients were treated in the study and it will, rare side effectiveness and rest. Serious side effects may not be found here. Fast down approved based on a study with a 195, a brute nib test subjects. In 20195 years after the drug was approved, an International Research team analyzed the Worlds Largest w h o database for side effects. At the time, some 90000 patients had been treated with a brute to nip world wide. The analysis showed that 13500 suffered serious side effects. 303 died of cardiovascular disease. 254 had brain blood flow issues such as t i a mazin theodore it and his hours out of this Analysis Shows very clearly that theres a very long list. Even look at some of the side effects, especially the blood flow issues in the brian pixels. Theyre not as rare as originally thought and a name wrong. Its a side effect. We have to inform our patients of emerson, so they can react quickly if necessary and stop take on a drug given and follow schnells he again, colonel medea i numbers. Mm. To come in as alter. Its not until september 2019, around 5 years after the drugs approval that t i appears as a side effect in the Product Description along with the recommendation to regularly monitor patients. We want to talk with the anson the company itself. It brought to nip as improve a car in europe. They offer a written response. Instead, we ask, how do you respond to doctors, accusations that insufficient information on potential side effects was available before the drug was approved. Among other things, johnson refers to a number of studies without stating whether these took place before or after the drug was approved. Quote, over a 150, improve because studies are ongoing, an 8 phase 3 studies in the area of chronic lymphatic leukemia. They continued, we continuously monitor the safety of our drugs and any potential side effects and finally improving his risk profile remains positive. Ah, these new types of drugs brought a new kind of hope when doctor started describing them around 20 years ago. Many even thought the battle against cancer would soon be won. But disappointment followed the euphoria a 2014 analysis of 71 cancer drugs by the American NationalCancer Institute showed that the new active ingredients could only slow chima growth by an average of about 2 months. Statistically some drugs only prolong patient life by a few weeks. Not easy for medical professionals who are gaps. My men come in fast. There was a drug that was heavily promoted for pancreatic cancer in their congo. In the end, it turned out that it only barely prolonged life can come in. They asked my house for some people just 14 days during the luncheon. Phillips is still statistically significant. Is too significant. Ok, lets use it. So 10. 00 to 14. 00 days is not a lot over a long period laying on, but its a dilemma for every one. Well, i look at what doctor wants to say. Im not going to offer this drug and this machine ish would have and what patient is going to say thats i dont want it and im, it does really some sub populations dont respond at all as a group. Why . Even use it . All right, well make america, but then you could see that for some patients it did work. Awesome. Then contact, so you can use it in those cases cocked ozium con to look, this is post Approval Research as to how do these drugs work . In reality, revealed is emitted come into integrated how do drugs actually get on the market . What hurdles do they have to clear to be approved in germany . The European Medicines Agency, ema in the amsterdam is responsible for approving drugs. This is where pharmaceutical Companies Ask for approval. They have to prove that a drug or a new combination of active ingredients both works and is safe. The process for regular approvals is always the same. In phase one, the drug is tested on a few patients. Here its about how the body processes the drug in phase 2, the medication is tested on several 100 patients depending on the disease. Here, the efficacy of the new drug is compared to a control group that receives an older one. In phase 3, the drug is given to several 1000 patients. This stage is about determining the safety efficacy and any rear side effects. But this standard is followed. Lesson less frequently. New drugs are being approved. Faster officials want patients to benefit from innovative drugs as quickly as possible. Under certain conditions, drugs can be approved after phase 2. After being tested on just a few 100 people. Wolf, t to load vig represents the german medical profession at the emer. Hes been critical of this trend in oncology for many years. Zeros on is to to slide an ongoing olivia, im very critical because an oncology, we have a significant increase in the number of accelerated approval processes or 2 impact is often not clear which patients would do best with the drug original. And we know too little about safety and side effect emerging authority should only agree to accelerated processes, an absolute emergencies, not, for example, with diseases by cove at 19 corbett noisily. From them we discovered extreme examples like this one approval of a drug for a special chima mutation was accelerated for 17 types of care. So, but it was tested only on very few subjects. For around half of the cancer types, it was tested on less than 10 patients and on just one patient each for appendix, liver and prostate cancers. Since 2015, 28 percent of all cancer drugs have been approved for sale using the accelerated process. The publicly funded institute for quality and efficiency and health care in colon thomas cause a heads up its drug assessment unit. Oh, he looks at all studies published on a new medication. Oh, does of a shiny its glass on phones are showing up on crypt, maybe come in and the her goal of the accelerated approval process for cancer drugs is to make them available to patients fast. Often whats in a sense of awful stead that since we have no data on whether they are better than existing ones, we cant know if patients will actually benefit. Lesters asked, isnt that gang up . Lighting is a percentage them, but in the fonts for tim. Another reason why the institute checks every new drug after approval to see if its better than the current therapy. And he asked his its with us and so found some unzip that and yeah, he does. If we look at these approval processes and we assess every new area, for example, every new cancer type, the drug is approved for the us and we see that only about half of these newly approved drugs. A proven to be more effective than a previous standard treatment therapy. Now, what does that tell you . Is fin the survey me and as kidney, its not enough. I will, thats my m, as its not about saying it always has to be certain that every new treatment is much better than what is already on the market. Unless the chances that it would be good or i would prefer thought that a newly approved drug offers some progress, lessons mini commend the institute was unable to determine any additional benefit from 46 percent of the cancer drugs approved since 2011. Hon skilled eichler. T