Come november for the general election should she ultimately lock up her partys nomination. Donald trump, and that is not only because he leads the republican delegate count or because he crushed his competition in indiana last night. We know for a fact it will be mr. Trump because he is the only republican left. Ted cruz suspended his campaign after his indiana loss and sources now say john kasich will do the same in an announcement scheduled for a little later today. So lets parse all of this out before we take Hillary Clinton live. Let me bring in our political guru, mr. David chalion, our cnn political director and cnn chief Political Correspondent dana bash, and we have m. J. Lee here in new york with breaking details first and foremost on the Ohio Governor. M. J. , what do we know about governor kasich . Well, john kasich, it sounds like, is out of the ration, and, remember, brooke, he has really had no path forward for a long time. This is not a sudden development, not even surprise, and i think really the nail is the coffin is when last night ted cruz in a surprise announcement to many people decided that he was getting out, even though his trump has not reached 1,237 delegates, and i think theres also no clearer sign that the gop primary season was really over than Reince Priebus tweeting last night, look, donald trump is the presumptive nominee and the party needs to now move forward and take on Hillary Clinton. Even though the kasich folks said Reince Priebus, were not out just yet and a lot has changed over the course of 12 hours. The strategy all along is he wanted to take this to a contested convention. I think last night it became very clear with trumps big win in indiana that he probably will get to 1,237 delegates, and its also important to keep in mind it became increasingly clear over the last couple of weeks that theres really no appetite among Republican Voters to take this to a contested convention. Many people clearly believe whoever goes into the convention with the most number of delegates should become the nominee so even if trump had come short 50 to 100 delegates or what say you, i think the appetite just would not have been there for the fight to take place. What a night for all camps involved, dana, and david. Let me just pose this next one to you. I know well push forward and look, of course, ahead. Once we hear from Hillary Clinton and well hear from donald trump as well. Wolf blitzer sat down with him at trump tower earlier today and my question, just for a second, can we talk about ted cruz and my question is, dana, you know, behind the scenes what do you think ultimate lire was it for them to say enough is enough . Was it, you know, the fact that he got trounced in the acela primary, you know . What was that moment, do you think, for them to to call it quits . You know, the acela primary which, of course, was last week, was an area demographically, geographically where he could say, you know, thats not my people. Indiana he couldnt say that. He put everything in indiana. I was with him there on monday. He gave it everything he got. He had everything set up the way that he wanted it to be so he really didnt have frankly any excuse but to beat donald trump if hes going to beat him anywhere. He had a oneonone race with him. It was a place where theres maybe more moderate than other midwestern states, but he had plenty of conservative electoral voters to mine, and he didnt win, and he didnt win in a big, big way, and, so, frankly, as somebody who has spent a lot of time with ted cruz, i was a little bit surprised that he did it so quickly. You were surprised, because of the delegate ground game, the outmaneuvering, all of that. Exactly. More than that, mine was almost a little bit more about his personality and his sort of psychological ability to retain and take pain because ive watched him for so many years be ridiculed in the senate for doing what he thought was right morally and political and philosophically, you know. Even a lot of his colleagues said he was just a dem gosh, and he was really ostracized for doing that, and so he has been able to deflect a lot of that kind of stuff and sustain really an uphill battle for what he called the good of the party and the will. People and conservatism, so i i was surprised that he did it so quickly, but it was a big loss, and this is not like him going to washington where hes just kind of doing his thing in the senate. It was all in. His wife was there. His kids were on the trail. They left school. They were being tutored on the road. Yeah. I mean, this was a Family Affair and it was just clearly enough. Brooke, can i extend that metaphor for a second. Please, please. It might be that ted cruz has an incredibly high political pain threshold, but you actually need to be alive politically in order to deal with pain, and Paul Manafort, Donald Trumps adviser i thought had the best quote. You were asking about the acela primary in indiana, and i think lets use Paul Manaforts words because i think they proved accurate. The acela primary was the nail in the coffin. Indiana was when ted cruz realized he was in the coffin, and that is what happened with indiana. David, let me stay with you, and, again, just reminding our viewers we will take secretary Hillary Clinton speaking oneonone with Anderson Cooper. This is the first after, yes, she lost indiana, but she is doing quite well. They are obviously hoping to clinch in the next month or so, and she now knows essentially who she will be running against come the general election. David to you just in terms of context before we take a break. Here we are, donald trump. I dont know. Watching him last night, did it almost seem to you he was surprised . It was very trumpesque quoting the polls. No major pontificating on the country or the campaign. Ragtag group of, you know, analysts that hes been running with for a number of months. What did you make of that moment . Well, i dont think he was necessarily anticipating sort of the formality of the moment of becoming the quote, unquote presumptive nominee. Thats not the kind of speech he wanted to give. He wanted to stick to whats been working for him and he was clearly holding back in some reserved way to not lash out at opponents. That was the biggest difference than weve seen other nights, but clearly he wanted to tick through the things that have been working for him, the poll numbers, the message. I will tell you though, brooke, what i heard last night more than anything else in that speech from donald trump was the message he is going to take to Hillary Clinton on the economy. He hit it over and over again. Our brand new cnn orc poll shows him beating her on the economy. Its the only issue of all the issues tested where hes ahead and guess what, thats the most important issue to voters, so that was my big takeaway from his speech last night. If Hillary Clinton has been running an economic message for the primary season dealing with Bernie Sanders on her left, how shes going to adjust to combat donald trump on his economic populism for the general election audience i think is one of the key things to watch. Its a great question and perhaps will be one tossed at her by anderson minutes from now. Again, just a reminder to all of you tuning in. Its a huge hour for us here on cnn. Moments from now, democratic frontrunner Hillary Clinton in her first oneonone interview since donald trump became the presumptive nominee. That will happen next. Well take it live, and well have a huge conversation out of it. Keep it right here. Youre watching cnns specks live coverage. Heres the plan. You want a family and a career, but most of the time you feel like youre trying to wrangle a hurricane. The rest of the time, theyre asleep. Then one day, hr schedules a meeting with you out of the blue. And its the worst 19 minutes of your career. 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Jusdoes that mean they have toer grow apart from their friends, or from the things they love to do . With right at home, it doesnt. Right at homes professional team thoughtfully selects caregivers to help with personal care, housekeeping, meals, and most of all, staying engaged in life. Oh, thank you, thank you. Youre welcome. Are you ready to go . Oh, i sure am. We can provide the right care, right at home. Welcome back. Im brooke baldwin. Right now democratic frontrunner Hillary Clinton with her very first oneonone interview since donald trump became the presumptive nominee. We turn to my colleague Anderson Cooper standing by live in chappaqua, new york. Anderson, the floor is yours. Thanks very much. Secretary clinton, thanks very much for joining us. Good to talk to you. Take us back to last night, the moment ted cruz dropped out and you realized who the nominee in the Republican Party was going to be. Well, it seemed pretty clear for some time how it was going to turn out, but i also know what its like to keep fighting to the end because i did that in 2008, and something can always happen, but it it didnt surprise me at all that it was over last night. Assuming you get the democratic nomination. Right. Are you ready for donald trump . I mean, hes already got an unflattering nickname for you . Hes unlike any other candidate probably certainly youve ever run against, anybody people have seen in a long time. Anderson, ive seen the presidency up close from two different perspectives, and i think i know what it takes, and i dont think we can take a risk on a loose cannon like donald trump running our country. You know, donald trump has said its okay for other countries to get nuclear weapons. I think thats just downright dangerous. He has said wages are too high. I think we need to have a raise for the american people, raise the minimum wage, get wages back going up. I think when he says women should be punished for having abortions, that is, you know, just beyond anything that i can imagine, i think most women can imagine. He did walk that back. Well, hes a loose cannon. Hes somebody who has said so many things, and im sure hell be scrambling and his advisers will be scrambling, but hes already said all of these things. He says Climate Change is a chinese hoax, and i think its real. Weve got to pull the world together to deal with it. You can do down a long list some of which hes tried to bob and weave a bit. I think its a risk. He is a loose cannon and loose cannons tend to misfire. If hes a loose cannon hes certainly willing to say things against a race against opponents. Weve seen this already that a lot of candidates were not prepared for on the gop side. Are you ready for that . Well, ive sort of been in the arena for 25 years, and i think nearly everything that can be thrown at somebody in politics and public life has come my way. You feel like you know how to run against him . Oh, absolutely. Im not running against him. Im running my own campaign. Im running to become president , to really deal with the economy, get it working again, take on all the barriers that stand in the way of people of getting ahead. I have a very Clear Mission in this campaign. But there were a lot of folks on the gop side who said that they would be running on the issues as well, and that wasnt they werent able to against donald trump. Well, maybe they just didnt have the experience. Maybe they just didnt want to take him on on issues because they actually agreed with him. Everybody in that republican primary didnt want to raise the minimum wage, dont believe equal pay is a problem, dont want to talk about Climate Change. A lot of the same views, so they were really trapped. They couldnt run a campaign on the issues that mattered to america, and i can, and i will. He talked about the economy last night and hitting an economic message that clearly hes going to echo going forward. He talked about your husband signing nafta, what he called perhaps in the history of the world the single worst trade deal ever done, and according to the latest cnn polling out just today by 50 to 45 margin voters said trump would do a better job handling the economy than you would. Hes got an economic populist message which is appealing to people. Well, well have to go back and talk about the history. 23 million new jobs in the 1990s. Incomes went up for everybody. If he wants to argue against peace and prosperity, he can absolutely do his best to make that case. Im going to talk though about what were going to do in the future, and i think that there are some lessons we can learn. The economy does better when we have a democrat in the white house. We saw the stark difference between my husbands presidency and george w. Bush who went back to trickle down economics which is also what donald trump is advocating, and then we saw barack obama have to rescue the economy from the failed economic policies of the republicans, so im more than happy to take that issue on, and i think that there is not only a lot of evidence on our side and certainly history on our side over the last 25 years, but any specifics that he has put out. He makes these grand statements and grand accusations. At some point when youre running for president you actually have to put a little meat on the bones. Youve got to tell people what it is youre going to do and how hes going do it. Does run a different kind of campaign than anyone else certainly on the gop side. He makes himself more available to reporters, calls in. Is that something youll do more of . He did it and it worked for him hand i think reporters now have a chance to ask some tougher questions. Its not enough to call in and give somebody a platform. Its now the time to make the tough decisions, and youve got to the ask him, okay, so what exactly would you replace x, y and z with . If youre against trade agreements how is that going to work . Im against bad trade agreements. Im for, you know, fair and free trade. I voted against some of the trade agreements that came before me when i was actually a senator, so lets get to the specifics. If you think wages are too high, how do you look americans in the eye and say hey, i know you havent had a raise for 15 years, but i dont think you deserve one. If youre going to have a budget that slashes taxes on the wealthy and throws our economy and our federal budget into the worst downward spiral of debt, tell us how thats going to work. I think its time to get serious. The man is the presumptive nominee, and, you know, being a loose cannon doesnt in any way protect him i hope from being asked the hard questions that he should have been asked during the whole primary process. Wolf blitzer asked him today about how hes going to be running against you and whether hes going to sort of change his tone and be more president ial. I want to play that exchange with wolf. Mmhmm. There was a little talk about will he be president ial . We had 17 people, all smart. One by one, week after week, boom, boom, boom, gone, gone, gone. I dont maybe want to change so much and do i want to use that same strategy for trade deals and i want to use that same but i feel like im a president ial person. Is the same strategy that you used to get rid of the other republican candidates you want to use now against Hillary Clinton . I would say yes, and, again, a lot is going to depend on how they treat me. If they treat me in a certain level, im not looking to do more. Youve seen im a counterpuncher more than anything else. I dont really like hitting people first because i dont know how i guess ive always felt that im better, like certain boxers, they are better counterpunchers. He says hes a counterpuncher. How how scorched earth is this race going to be . You know, hes the one thats making that decision, anderson. Not me. Hes the run who has run the campaign insulting people, demeaning women, degrading people with disabilities, talking about keeping muslims out of the country. Hes the one who has been running that kind of very negative aggressive bullying campaign. He could choose to run whatever campaign he wants to run. Im going to keep staying on the campaign im running. I have more than 3 million votes over senator sanders and i have 1 million votes over trump. Im going to keep telling people what i will do as president and im going to keep being specific because i think people want to know what youre going to do and they can hold you accountable that way. Elizabet