the date on the video suggests it was shot today. the town is near the front line of the fighting, about 20 miles from the disputed city of bakhmut. the sound, and the way the people in the street look up, suggest it may have been a missile or possibly an artillery shell. ukrainian officials say at least 3a other people were wounded. the attack happened shortly after the us secretary of state antony blinken arrived in kyiv — the first visit by a senior american official since ukraine launched its counter—offensive against russian forces. our diplomatic correspondent paul adams gave me this update from kyiv. yeah, this happened about three hours ago. and as president zelensky has indicated, he was very quick to point the finger of blame at russia. he actually said it was russian artillery that was responsible for this. this town is within russian artillery range. we don't yet know exactly what the nature of the projectile was, but certainly the images that have circulated subsequently of the damage done are pretty horrendous. blood inside shops, bodies lying in the street, mangled cars for some distance. this was a very considerable explosion and we think probably one of the worst single incidents of its kind since around april. you know, ukraine has become terribly familiar with devastating attacks, but it has been a while since something on this scale occurred. rescue workers obviously still on the scene looking for survivors, but certainly the government here in kyiv in absolutely no doubt as to who was responsible. and paul, we'll get more details on that as the story develops. but as i mentioned earlier, this attack came shortly after antony blinken, the us secretary of state, arrived in kyiv and a big announcement is expected. what what more do we know about that? yeah. so this is mr blinken�*s fourth visit to kyiv since the full—scale russian invasion, his sixth as secretary of state. and every time he comes here, he comes bearing gifts of some kind or another. there have been dozens now of american pledges over the last 18 months of assistance. we believe this one... some of the details we're likely to hear today, perhaps others later in the week, we think will total something in the region of $1,000,000,000. that's pretty much par for the course. it has to be said, in terms of american pledges, it'll be a mixture of military assistance, assistance, probably the bulk of it, but also civilian assistance, because the americans are very keen to try and prop up ukraine's economy, which has been absolutely devastated by the conflict over the last 18 months. but for mr blinken, this... you know, he received a very warm welcome here. he's a very familiar face. and even before he arrived, there was the sound of war here in the capital. air sirens. with america's secretary of state just hours away, a fresh wave of attacks at dawn. kyiv�*s well—drilled air defences called into action once more. outside the city, a supermarket damaged by falling debris wrecked early in the war in the process of being repaired — now wrecked again. and a familiar welcome to mr blinken, bringing a fresh pledge, more than $1,000,000,000 in security and other assistance. every time i'm here, i'm struck by the extraordinary bravery and resilience of the ukrainian people, the ukrainian forces. ukraine's leadership. and i'm here first and foremost to demonstrate our ongoing and determined support for ukraine as it deals with this aggression. this is mr blinken�*s first visit since ukraine launched its counter—offensive in june. after weeks of slow progress, ukraine says the pace is picking up. the cost in men and equipment is high. president zelensky says more supplies are on the way and that ukraine will step up its own production. translated: there will be new supplies. it is very important that there will be new production of our weapons and we have outlined several priority items with the warriors. this is what needs to be done. we will do it. at kyiv�*s wall of remembrance, yet another gesture of solidarity. denmark's prime minister paying her respects, her country among three planning to send f—16 jets by the beginning of next year. and so mr blinken is actually going to be spending the night here in kyiv. i think that's a first. and he will be holding a press conference with ukraine's foreign minister, dmytro kuleba, a little bit later on. probably get to hear some more details about the precise nature of this latest package of assistance. some more details to bring you on the breaking news from a short while ago, a manhunt has been launched after a terror suspect escaped from hmp wandsworth this morning. daniel khalife was awaiting trial after being accused of leaving fake bombs at a military base while serving as at a military base while serving as a soldier. the police say he is six and was last seen wearing a white t—shirt, red and white chequered trousers and brown steel toe capped boots. police say he has links to kingston and is most likely still in the london area. that is breaking news that a manhunt has been launched after a terror suspect has escaped from hmp wandsworth prison. scientists have grown an entity that closely resembles an early human embryo, without using sperm, eggs or a womb. the weizmann institute team say their synthetic embryo model looks like a "textbook" example of a real 14—day—old embryo and it even released hormones that made a pregnancy test turn positive in the lab. the aim for these embryo models is to provide an ethical way of studying how stem cells form various organs in developing embryoes. it may one day make it possible to group tissue and organs for transplantation using embryo models. let's speak now to an expert in this field — robin lovell—badge, from the francis crick institute, in london. thank you forjoining us. we will go into the details of how all this has happened, but first we want to get your reaction to have significant a breakthrough this is.— breakthrough this is. been seen vafious breakthrough this is. been seen various stories _ breakthrough this is. been seen various stories this _ breakthrough this is. been seen various stories this year, - breakthrough this is. been seen i various stories this year, example, injune from several labs that various stories this year, example, in june from several labs that were injune from several labs that were claiming to in june from several labs that were claiming to have these stem cell —based embryo models that were mimicking these aspects of the early human embryo this is the first one that actually looks like you have essentially a complete normal looking human embryo corresponding to an important stage, which is about 1k days of development. haw about 14 days of development. how si . nificant about 14 days of development. how significant is _ about 14 days of development. how significant is this _ about 14 days of development. how significant is this advanced scientifically compared to the limits of what was possible before? i think it is very important because this is the first time we have something that resembles, in order details the scientists were able to look at, a normal human embryo in terms of their appearance, their organisation and molecularly, in terms of the genes that were active or inactive. that means it is a good model to start doing experiments, to address how human embryos develop normally and what happens when things go wrong, so what might happen in a case of disease or what might lead to higher incidences of miscarriage, for example. in might lead to higher incidences of miscarriage, for example.- miscarriage, for example. in very basic minced _ miscarriage, for example. in very basic minced terms, _ miscarriage, for example. in very basic minced terms, can - miscarriage, for example. in very basic minced terms, can you - miscarriage, for example. in very i basic minced terms, can you explain exactly how this was achieved? —— a need to begin with a stem cell, it is a stem cell that can begin rise to any cell type in the body. there are two sources, _ to any cell type in the body. there are two sources, embryonic - to any cell type in the body. there are two sources, embryonic stem | are two sources, embryonic stem cells which come from early implantation, early—stage embryos, or implantation, ea rly—stage embryos, or so—called implantation, early—stage embryos, or so—called induce stem cells which can, for example, he derived by a reprogramming in adult out like a skin cell into something that resembles almost very close to or identical to an embryonic cell stem. you take them, and in this case to put them in different culture medium is to trigger their specialisation into basically the thought cell types that make up the early embryo around the time of the implantation, so that is you have the outer cells, but normally give rise to 3%, cells that normally give rise to the yolk sac, cells that give rise to the embryo proper and you have some cells that give rise to extra needed, which is things like the umbilical cord. they combine this cell and appropriate ratios, they got the official about right, it seems, about a clump of hundred and 20 cells of these four different types and then what you don't rely on is the ability of this clump of cells to organise itself, to pattern itself, to organise itself. you get cell division and growth of a structure and you get this organisation into something that resembles an early stage embryo and thenit resembles an early stage embryo and then it goes on to a 14 stage embryo, which are beginning to develop some complexity. we have limited time _ develop some complexity. we have limited time so _ develop some complexity. we have limited time so i _ develop some complexity. we have limited time so i want _ develop some complexity. we have limited time so i want to _ develop some complexity. we have limited time so i want to get - develop some complexity. we have limited time so i want to get this i limited time so i want to get this clarification in terms of what is the main difference between these models and naturally conceived embryo. models and naturally conceived emb o. , ., ., embryo. the first thing i have to oint out embryo. the first thing i have to point out is _ embryo. the first thing i have to point out is to _ embryo. the first thing i have to point out is to get _ embryo. the first thing i have to point out is to get a _ embryo. the first thing i have to point out is to get a structure i point out is to get a structure spawning in only 1% of these aggregates that actually work, normal human development is much more successful than that. it is not really ready to use them to study all sorts of things but it is getting there. and i'm sure there will be ways to improve success rates. they are not coming from a fertilised egg, so there is no fertilisation and they are very distinct from a normal embryo. they also haven't gone through these very early stages of embryo formation, which might be critical for these structures to be able to implant and develop in a worm. that couldn't be done because it would be illegal to do it with this embryo models anyway, butjust to say, we cannot tell whether they are truly normal but from all the appearances in the paper they do look pretty good. insert; paper they do look pretty good. very briefl , for paper they do look pretty good. very briefly. for a — paper they do look pretty good. very briefly, for a nonexpert like me, this seems incredibly exciting. for an expert in the field, are you very excited? i an expert in the field, are you very excited? ., an expert in the field, are you very excited? . .. ., , , , excited? i am, actually. very. it is the first time _ excited? i am, actually. very. it is the first time we've _ excited? i am, actually. very. it is the first time we've seen - excited? i am, actually. very. it is. the first time we've seen something that really seems to resemble the normal embryo, whereas the previous attempts were defective in some way. it doesn't mean they were not useful to study aspects of development, but this is something that is like a complete embryo. it raises ethical issues but let's leave those for another time.— issues but let's leave those for another time. issues but let's leave those for anothertime. , ., ~ another time. absolutely, thank you so much for — another time. absolutely, thank you so much for talking _ another time. absolutely, thank you so much for talking us _ another time. absolutely, thank you so much for talking us through - another time. absolutely, thank you so much for talking us through that. j a manhunt has been launched after a terror suspect escaped from hmp wandsworth this morning. daniel khalife was awaiting trial after being accused of leaving fake bombs at a military base while serving as at a military base while serving as a soldier. police say he is six and was last seen wearing a white t—shirt, red and white chequered trousers and brown steel toe capped boots. police believe he is most likely still in london but have warned the public not to approach him. let's get more on this from my colleague greg mckenzie. let's see if we can get through to him now. tell me a little bit about what the consents are for the safety of the public. we had a little bit of it there but bring us more details. good afternoon, the police have simply said do not approach this suspect who escaped from the prison at about 715 this morning —— 7:50am. it is wandsworth prison, a victorian jail, and this individual managed to escape this morning. police say do not approach him and simply called them immediately. they believe he has links to some areas in the capital, kingston and some other places in london but he was being housed at wandsworth prison on remand and was due, had been in court, given remand back injanuary this yearfor a number of court, given remand back injanuary this year for a number of terrorism offences, one leading to the official secrets act as well. a 0fficial secrets act as well. a number of terror offences. he was a former british soldier as well and has simply managed to escape. we do not know how he left the prison this morning. there is a police briefing in the next hour but ultimately there is now a manhunt for daniel khalife who is 21 and has absconded from the jail this morning. what from the “ail this morning. what more do from the jail this morning. what more do we _ from the jail this morning. what more do we know— from the jail this morning. what more do we know about - from the jail this morning. what more do we know about the - more do we know about the background, give us a little bit more context about the background. we know he was accused of planting fake bombs, it was a little bit more context. we fake bombs, it was a little bit more context. ~ ~ ., ., , ., fake bombs, it was a little bit more context. ~ ~ ., ., , context. we know he was a serving member of — context. we know he was a serving member of the _ context. we know he was a serving member of the british _ context. we know he was a serving member of the british army, - context. we know he was a serving member of the british army, he i context. we know he was a serving | member of the british army, he was charged on the 27th of january for the following offences. police have released these details in the last few minutes, attempt to elicit information of a kind likely to be useful to a person committing or preparing an act of terrorism. that is contrary to section 58 a of the terrorism act 2000. also in a back inside staffordshire, accused of placing an article with the intention of inducing in another a belief that the said article was likely to explode or ignite, and therefore cause personal injury or damage to property. he is also charged with another offence in terms of the official secrets act, so a number of serious offences that he was currently being held on remand for and was due to appear in court to face those charges, but has now simply escaped from wandsworth prison. just now simply escaped from wandsworth rison., , ., , now simply escaped from wandsworth rison. , ., , , now simply escaped from wandsworth rison. , ., prison. just finally, 'ust to reiterate, i prison. just finally, 'ust to reiterate, what i prison. just finally, just to reiterate, what should i prison. just finally, just to i reiterate, what should members prison. just finally, just to - reiterate, what should members of the public do if they have any information?— the public do if they have any information? . , ., information? the police is asking --eole information? the police is asking eo - le to information? the police is asking peeple to call — information? the police is asking people to call them _ information? the police is asking people to call them if _ information? the police is asking people to call them if they i information? the police is asking people to call them if they spot l people to call them if they spot daniel khalife, who is 21, and simply call them. they are saying do not approach him. his picture is here. if you do see him, the advice is to contact the police immediately, letting them know where you have spotted him so they can take appropriate action to send him back to jail. take appropriate action to send him back to “ail. ., ~ , ., take appropriate action to send him back to “ail. ., ~ i. . ., back to “ail. thank you so much for that. rishi sunak has insisted he's acting �*as quickly as possible' after ministers published a list of nearly 150 schools in england made of concrete which is liable to collapse. more than 100 schools were ordered to fully or partially shut buildings due to concerns about raac — nineteen were forced to delay the start of the new term. analysis by the bbc has found that thirteen schools in england containing raac had their re—building plans cancelled in 2010. the issue came up at prime minister's questions — take a listen. doing everything we can to fix this quickly and minimise the disruption to children because my education. we make no apology for acting decisively in the face of new information and let me provide the house and an update of where we are, of the 22,000 schools in england, the vast, vast majority will not be affected. the vast, vast ma'ority will not be affected. ., ., , the vast, vast ma'ority will not be affected. . ., , , the vast, vast ma'ority will not be affected. . , ,, .,~ the vast, vast ma'ority will not be affected. . , ,, ., affected. that was rishi sunak. have affected. that was rishi sunak. have a listen to how _ affected. that was rishi sunak. have a listen to how the _ affected. that was rishi sunak. have a listen to how the leader _ affected. that was rishi sunak. have a listen to how the leader of - affected. that was rishi sunak. have a listen to how the leader of the i a listen to how the leader of the opposition responded. it is a listen to how the leader of the opposition responded.— a listen to how the leader of the opposition responded. it is the sort of thin . opposition responded. it is the sort of thing you — opposition responded. it is the sort of thing you expect _ opposition responded. it is the sort of thing you expect from _ opposition responded. it is the sort of thing you expect from cowboy i of thing you expect from cowboy builders saying that everyone else is wrong, everyone else is to blame, protesting they have done an effing good job. the difference is that in this case, the cowboys are running the country. live now to frances read who's at a school in north west london. what's the situation at the school you are near? it what's the situation at the school you are near?— what's the situation at the school you are near? it has been a mixed resonse you are near? it has been a mixed response fr