Its 7am in singapore and midnight in london. There is new hope today for thousands of families who live with the prospect of passing on inherited diseases to future generations. For the first time, scientists in the us, along with experts from china and south korea, have successfully repaired a faulty gene in Human Embryos. But critics are warning that the technique could, ultimately, be used to create so called designer babies. Our medical correspondent fergus walsh reports. The goal could not be more ambitious to eradicate inherited diseases. These scientists have taken an impressive first step on a long road, editing dna in Human Embryos. So how is it done . Inside the nucleus of each of ourselves is our genome, billions of pieces of dna. Its the Instruction Manual for life. The scientists were targeting a faulty gene that causes a serious Heart Condition. They fertilised a healthy egg with sperm from a man carrying the faulty gene. They then injected the Gene Editing System known as crispr. This scans the dna, like a spell check or a satnav. It then cuts both strands of the dna and removes the faulty gene. A healthy copy of the gene from the egg was then naturally inserted. Now here are some of the embryos from the study in the journal nature after being edited. 42 of 58 embryos were corrected. They were allowed to develop for five days. None was implanted. We are very excited about all the work, of course. The research has been welcomed by a team in london who have a licence to edit Human Embryos. They say the technology could eventually help many families. There are some nasty genetic diseases, such as huntingtons or, as in this case, a disease that affects Heart Function later in life, which can basically blight families for many generations. So a method of being able to avoid having having affected children passing on the defective gene could be really very important for those families. Nicole mowbray has the same Heart Condition which was corrected in Human Embryos. She now has a defibrillator implanted in her chest in case her heart stops. She has a 50 risk of passing on the condition, but is unsure whether she would ever consider gene editing. I wouldnt want to pass on something that caused my child to have a limited life or a painful life or a life of risk. I mean, that does obviously come to the front of my mind when i think about having children. I wouldnt want to create the perfect in inverted commas child. I feel like my condition makes me me. And some are worried Gene Editing Technology could lead to an era of designer babies. Previous attempts at gene editing Human Embryos in china led to serious errors in the dna so a lot more research is needed before this could be used to treat patients. And it raises ethical issues about how far science should go to create healthy babies. Also this hour ina deal in a deal that could be worth more than a quarter of 1 billion, the brazilian foot taller neymar looks like he could be leaving barcelona and joining psg. Richard conway is in paris. Fans visiting the club shop in the centre of paris are getting excited, and thats because a deal for neymar is inching slowly forward. Weve seen over the past few days the player go from shanghai, where he was in commercial duties, and flying back to barcelona. Hes been excused from training and now barcelona say, pay us training and now barcelona say, pay us the money, and, ps6, you can have the player, so we will have to see how it plays out in the coming hours, maybe days, but there is now an increasing certainty that neymar will be a Paris St Germain Player for the coming season. The implications will be huge for barcelona without one of their leading players. And for paris st germain, who won to bridge the gap between Champions League wannabes to Champions League winners, and players have a requirement to live within their means. This size of deal, the money involved, is such that many clubs, many individuals involved that the highest levels are looking at it and wondering whether paris st germain will be able to live within those obligations. For now, though, the fans here in paris just want to know one thing when will neymar sign . Germany has ordered the Press Attache at the Vietnamese Embassy to leave the country within 48 hours in response to the suspected kidnapping of a former Vietnamese Communist Party member. The German Foreign ministry called the kidnapping of Trinh Xuan Thanh an unprecedented and scandalous violation. Mr thanh, whos the subject of an International Arrest warrant, disappeared in berlin nine days ago. Two people have been killed when a Light Aircraft made an Emergency Landing on a beach crowded with sunbathers in portugal. A 50 year old man and an eight Year Old Girl died on saojoao beach near lisbon. The two people on board the plane were unharmed. Researchers have warned that by the end of the century hundreds of millions of people in south asia will face Humidity Levels so high they reach the limit of what humans can survive. Thats if Global Warming isnt curbed. Agricultural workers are most at risk. The study is the first to look at the human bodys ability to cool down. Venezuelas top electoral official has dismissed allegations sundays Election Results were wildly exaggerated. Hours earlier, smartmatic, the british based company that provided the voting system, said the turnout in the controversial election was inflated by at least one million votes. Electoral Authorities Say 8. 1 Million People voted and theyre threatening legal action against smartmatic. This was london earlier on wednesday. It was pouring down with rain but that didnt put off the Duke Of Edinburgh from attending his final solo Public Engagement before he retires. 96 year old Prince Philip has completed over 22,000 engagements on his own since 1952. Here he is as Captain General of the Royal Marines the duke attended a parade to mark the finale of the 1664 global challenge, a series of strength challenges raising money for charity. Theres been an alarming rise in the rates of Hiv Infection in the philippines, with Government Health officials calling it a national emergency. Right now the country has the Fastest Growing hiv epidemic in the asia pacific region. 10,500 people were infected with hiv at the end of 2016, the vast majority of them men. Thats a 1a0 increase since 2010. I spoke to carlos conde from Human Rights Watch earlier, and asked him why the hiv epidemic is such a problem in the philippines. We are quite disappointed by the response of the government to the hiv epidemic over the years. The reason for that is because, while goofy government has been doing the best it could to provide treatment and screening for hiv for those people, a lot of efforts are not being directed at promoting condom is all safe sex education, particularly among the young population in the philippines, and theres still a lot of stigma in the philippines, particularly around access to condoms, so people with hiv and particularly men who have sex with men are facing a lot of challenges because of the environment. Indeed, carlos. You mentioned in your report concerns about the rollout of proven low cost interventions, condom access, for instance. Why do you think the government are not implementing these measures. Well, theres several factors. One of the these measures. Well, theres severalfactors. One of the main ones actually is this the lack of political will to go against conservative elements in philippine society, particularly the Roman Catholic church, who generally do not approve of contraception including condoms, and the National Government is not keen on promoting condoms nationally because of the backlash from the Catholic Church and its conservative allies. A local politician for instant keep in mind local government units, towns and cities in the philippines, are the ones on the front line to fight this epidemic, but because they are run by politicians, some of them, many of them, in fact, are not inclined to go against the church, so this is why condoms are not promoted. Thats a real conundrum because the Roman Catholic church has huge influence in the philippines. How can this be resolved, the issue that Government Officials are not able to go up against this enormous influence . Officials are not able to go up against this enormous influence7m ta kes a against this enormous influence7m takes a lot of political will on the pa rt takes a lot of political will on the part of the administration, and in other issues, this has shown some good level of political will, and we just hope that he can show that, in the fight against hiv in the philippines. It takes a lot of political will, it takes a lot of, i would say, fully tickle strength on his part to go against the local Government Officials and just to tell them that fighting hiv is a priority. And really, in the final analysis, the hiv epidemic here in the philippines has not really been given a lot of attention because of the stigma that is attached to it, and we see that a lot still. Youre watching newsday on the bbc. Still to come on the Programme Life story. The world of singapore in the 1970s. We speak to the star who starred and directed in the movie wonderboy. Also, his views often provoked and shocked many. Now a new movie about the partition of india. The question is whether we wanted to save the japanese people and click chance on being able to win the war. The invasion began at two a. M. Mr bush, like most other people, was clearly caught by surprise. And we call for the immediate and unconditional withdrawal of all the iraqi forces. 100 years old and still full of vigor, vitality and enjoyment of life. No other king or Queenin Enjoyment of life. No other king or queen in British History has lived so long, and the queen mother is said quietly to be very pleased indeed she has achieved this landmark anniversary. This is a Pivotal Moment for the church as an international movement. The question now is whether the american vote will lead to a split in the anglican community. This is newsday on the bbc. Im in singapore. Im in london. Our top stories scientists have developed a Gene Editing Technique which could one day be used to eradicate inherited diseases. Health officials in the philippines have described the countrys hiv epidemic as a national emergency. And a Scientist Filming Sharks off the coast of cape cod got some incredibly close up shots of a great white. The three and a Half Metre Shark looks like it wanted to get its jaws round the camera. That video is one of our most watched on bbc. Com. Lets ta ke lets take a look at some front pages from around the world. The china daily reports on tensions at the countrys border with india and a warning from beijing after its Foreign Ministry released photographs showing indian troops encroaching on chinas territory to obstruct the building of a road. In the japan times, Government Officials have assessed the severity of a nuclear exposure accident to be level two on the zero to seven international scale. The accident happened injune at a Research Centre where five workers suffered from internal radiation exposure. The front page of the strait times reports on a Ukrainian Pilot awarded for saving the lives of his passengers and crew on board. He was literally flying blind when a hailstorm shattered the planes windscreen and he was forced to pull off an Emergency Landing in istanbul. Now, what stories are sparking discussions on line . Well, sharanjit, its a picture of empty bus seats that has caused a stir on line. A norwegian anti immigration Facebook Page mistook it for a photograph of women wearing burqas. The Facebook Page, which translates as fatherland first, is now being ridiculed on line for its obvious mistake. President trump has reluctantly signed into law a bill imposing sanctions on russia over its policy in ukraine and alleged meddling in last years us president ial election. 0ur washington correspondent, laura bicker, explained how the president was boxed in to the decision. Congress went through with this legislation. It was unanimously approved by both republicans and democrats. The Way American Democracy Works is this now goes to the desk of the president. Is that there are all weekend. He said he would sign it and now he has. He issued a number of responses as to why he did not want to. One of those if it will limit his ability to lift or leave sanctions from russia. Another reason is it places limits on the amount of money that americans can invest on Russian Energy projects. He believes some of these legislations will limit American Firm business in russia. That is one of the reasons why he says he is fighting this significantly flawed. Finding. And he finds congress is overreaching and stepping on his toes. That is one of the reasons why he says this is unconstitutional. Singapore prides itself on its squeaky clean image. Is that the case . It hasnt always been that way. Wonder boy, a movie that opens here today, is a frank look at the more edgy era of the 1970s that puts the sin back in singapore. The movie is loosely based on the teenage years of singaporean entertainer dick lee, as he tries to break into the music industry. Lets take a quick look at the film. Why so dark . You need courage to play rock music in this school. Hard rock. The wonder boy that was a quick clip of the wonder boy which opens in cinemas today. The director and the person who inspired the film joins me now. Welcome to the programme. It is loosely based on your life. It depicts a very different singapore from what we know today. One from the 1970s. What Will Singapore audiences think of it . I thought it was about time to show the singapore i grew up in. We had our 50th birthday a couple of yea rs had our 50th birthday a couple of years ago. Had our 50th birthday a couple of years ago. Ten years ago. Yes. We saw the 1960s singapore. The emphasis has always been about how we have come to where we are, perseverance, hard work, being good and clean. All of that. But that wasnt what i experienced as a teenager. I thought it was time to show the 70s. You are very much an Establishment Figure now. You have written the Traffic Songs for Singapores National day. How will authorities react to it . To set things straight, that is not what i do. I pick songs that have become patriotic songs. Myjourney do. I pick songs that have become patriotic songs. My journey as a composer has been to find myself as a singaporean. Being such a young country, we did not have much of a National Identity back then. So, umm,i National Identity back then. So, umm, ithink National Identity back then. So, umm, i think that we are now a little bit more open. Singapore is a little bit more open. Singapore is a little bit more grown up and able to look at ourselves. I dont think this will cause a huge scandal. 0k. For audiences not familiar with you elsewhere, you are considered the National Treasure of singapore, the closest we have got to someone like elvis, i suppose. Closest we have got to someone like elvis, isuppose. Your career closest we have got to someone like elvis, i suppose. Your career has gonein elvis, i suppose. Your career has gone in line with the Economic Transformation we have seen in singapore. But in this movie, we see your early struggles being tough for you, especially in a restrictive society. The 70s, The 60s In Singapore was a good time for singapore was a good time for singapore with music. A golden age. But in the 70s, everything ended because of National Service and effo rts because of National Service and efforts to clean up singapore. That was when there was a ban for long hairfor men. If you played guitar and had long hair, you a drug addict. It was a bad image to have degenerative Western Culture and music. As a teenager wanting to have fun, we had to play our music underground. That was a difficult and scary time. But i wanted to do what i wanted to do. I was not a drug addict. You are a songwriter, you are a well known singer. But this is really your first time making your directorial debut. What was it like making a film about your life . When i was first approached for this film i turned it down because i thought i dont want to do a film about me and all of that. But then i relented. I thought i would not like the experience, but actually i loved it. I cant wait to do more. I heard you singing before. You have a wonderful voice. Producing something . Just for you. This is a song from that movie which is from my first album which is called life story. This is my life story, minute by seconds a story, that ages with each year and birthday cake. Wonderful. Thank you so much. Wonder boy opens in cinemas today. 70 years after the end of british rule in india, a movies being made about a writer from the time who wasnt afraid to speak his mind. Saadat hasan manto is most famous for his Short Stories, often a raw and a personal response to his experiences, including the horror of partition. Yogita limaye visited the set of the film to find out more. He wrote about the chaos following the partition of india. He had more than 25 books of Short Stories and essays. Saadat hasan manto was one of the most prolific writers of the era when india was split and pakistan was born. It is rolling. Now, a movie is being made about Saadat Hasan Manto in mumbai, a city he once called home before he moved like many muslims did at the time. In this scene, Saadat Hasan Manto, played by a popular indian actor, is defending his work. He wrote about issues considered like prostitution, sex, and alcoholism. Taboo. Many say he was the greatest writer of south asia. He wrote about Pakistani Society in the 1990s. He was no less than one of the greatest writers of the world, like shakespeare, to me. He fought several legal battles, but was never considered a convicted. This film about a man and free speech has come at a time when censorship has become a concern for the industry here. Many people have to edit their movies before they are allowed to be screened in cinema and homes. This might be a story from 60 yea rs homes. This might be a story from 60 years ago, but the issues it raises are relevant in present day india. Years ago, but the issues it raises are relevant in present day indialj think it is extremely inspirational at times when we are constantly being censored. A time when Freedom Of Expression has become the biggest casualty, not just in of expression has become the biggest casualty, notjust in india, but all over the world. I think it is extremely relevant to the times were living in. I think we need to respond to what is happening today. It is almost like i am taking refuge, making him say all of the things that i want to. Saadat hasan manto died in 1955, but his work is still treasured by many, and his message, perhaps still as important as it was 70 years ago. Bbc news, mumbai. You have been watching newsday. And before we leave you, could we defend the world from aliens . If you think youre up for the challenge, nasa is seeking a new planetary protection officer, and willing to pay up to 180,000 for the successful applicant. Of course, the position is more of a Desk Job Protecting the world from space contamination. Nevertheless, the job title is capturing the hearts and minds of space enthusiasts world wide. I will be back with the headlines. Stay with us. More to come. See you soon. Hello. The area of low pressure that brought the rain on wednesday is still close enough during thursday to produce showers, making it windy. It is edging north east gradually. Not quickly enough for many of us before it gets to scandinavia and improves. Plenty of showers from the word go across many parts of the uk. The north and west in particular. Some will be heavy. The risk of thunder and hail. A picture. Some will be heavy. The risk of thunderand hail. A picture. Eight oclock in the morning, showers scattered in south west england. Much of central and Eastern England will be dry at this stage. Sunny spells around. England and wales, It Isa Spells around. England and wales, it is a windy day. Unseasonably for the time of year. Gusty winds. Plenty of showers in Northern England and northern ireland. Beginning to pull away to be showers in scotland to the west. Longer spells of rain in the west. Longer spells of rain in the northern isles. Easterly winds. Risk south westerly gust of wind in england and wales will be noticeable. Brisk. Show is fading in the afternoon, especially in england and wales. They linger in scotland. Slow moving with light winds. Thundery downpours in Eastern Scotla nd winds. Thundery downpours in Eastern Scotland during the afternoon. Temperatures, high teens, low 20s. The first day of the womens british 0pen we have the threat of some heavy showers moving through. Some Will Fade Thursday Night and to friday. Some styles of rain. Spells. Edging southwards. They are living around the area of low pressure which has not gotten to scandinavia yet. The breeze is down. More sunshine. Feeling pleasant between showers. For the bulk of the uk, the showers away from scotland will be few and far between. Those temperatures, well, the low 20s. Most in the high teens. The big picture going into the weekend, a ridge of High Pressure trying to go in. We will still see showers on saturday, especially in north england, north wales, scotland. They will be more numerous in that area. Temperatures in high teens, low 20s. A chilly night on saturday, sunday with drier weather. This is bbc world news. Our top story for the first time scientists have successfully repaired a faulty gene in Human Embryos. The us and south korean team used gene editing to correct dna that causes a deadly Heart Condition. Critics warn that eventually the method could be used to produce so called designer babies. The rate of Hiv Infection in the philippines has become the highest in the asia pacific region. Health officials have described it as a national emergency. And this video is trending on bbc. Com a Scientist Filming Sharks off the coast of cape cod got some incredibly close up shots of a great white. Luckily the three and a Half Metre Shark shows more interest in the camera than the scientist. Thats all from me now. Stay with bbc world news. Now on bbc news, its time for hardtalk
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