Yes, this is a different vaccine and logistically it is a bit different in terms of how we handle it and how we deliver it. But we feel ready and we deliver it. But we feel ready and we are raring to go to get it started for our community. As another deadline is passed, talks over a post brexit trade agreement resume the uk and eu agreeing to go the extra mile for a breakthrough. I must apologise for my friends misbehaviour. I think you bloody well should the doyen of espionage writing tributes to spy turned authorJohn Le Carre, whos died at the age of 89. And coming up on bbc news liverpool will be forever grateful. The world of football pays tribute to Gerard Houllier, as the former liverpool manager dies at the age of 73. Good afternoon, welcome to the bbc news at one. London and essex an area covering more than nine Million People looks likely to be moved into tier 3 of covid restrictions. Health ministers and officials are understood to be deeply concerned about the sharp rise in virus cases across the capital. It comes as the mayor of london, sadiq khan, is calling for secondary schools and fe colleges to close early if theres no mass Testing Available ahead of christmas. Schools in greenwich became the first in england to move to online. Downing street says it expects all schools and colleges in england to remain open until end of term on thursday. Andy moore reports. Mobile testing units have been sent the parts parts of london, kent and essex which have expensed recent rapid rises in infection rates. London is currently in tier 2 and could go into tier 3 f rights continue to escalate. If the government decides to move london to tier 3 they must provide additional Financial Support of those businesses who otherwise will go bust, hundreds of thousands ofjobs will be lost and its far better for the government to keep these businesses afloat by additional Financial Support rather than the alternative, which is these businesses going bust and hundreds of thousands of londoners losing theirjobs. Scientists are concerned about the speed of the rise in infection rates in parts of london and the south east. Infection rates in parts of london and the southeast. London probably doesnt need to go into tier 3 because otherwise we are going to just have even more problems, were coming up to christmas and the relaxation of the rules for the christmas period, and then we are looking down the track had problems injanuary, looking down the track had problems in january, february. Looking down the track had problems in january, february. Parents and children arriving this morning at primary schools in greenwich what is now going to be the last day of term. Parents at these schools were informed yesterday that they would be closing a few days early and switching to Online Learning where possible. What can we do . We need to just go on with it and get of the way. At least it would help the incidents, thats fine. It is too short notice to get any sort of child in place. So we will be taking the day off unpaid, coming up to christmas, which is not doable. People mix while they are dropping the kids at school so we can see that the cases are rising. They have to do what they have to do. Its a shame things have been left till the last minute, this should have been done ages ago. The labour leader of Greenwich Borough Council said he had to take immediate action because of what he called the exponential rise in covid cases in the borough. They have risen by about 60 in one week and now stand at 248 per 100,000 people. In the letter to pa rents, 100,000 people. In the letter to parents, danny thorpe said. London mps have been briefed on the increasingly serious situation in the capital. He move to tier 3 now looks highly likely and that announcement could come as early as this afternoon. Andy moore, bbc news, greenwich. With me now is our health editor, hugh pym. What are we expecting . We are certainly expecting a statement from the Health Secretary, matt hancock, at half past three and more detail will be set out their photo but certainly talking to mps, london mps we re certainly talking to mps, london mps were briefed this morning by Health Officials and Council Leaders across the capital are all expecting a move up the capital are all expecting a move up to the highest tier in england, tier 3, possibly even tomorrow or in the ensuing days. What does that involve 7 the ensuing days. What does that involve . It is already being imposed on certain other areas of england, it pubs, bars, restaurants have to stop taking customers into their premises, it will be taken away only. If that is imposed in london it will hit a very big sector of the hospitality industry, really, for the whole of england. And it prohibits meeting people indoors or in private gardens. We can only meet people outside your household or your support bubble in a public park 01 your support bubble in a public park or somewhere like that. Essex is also likely to move up to tier 3, kent is already in that highest tear, and looking at the top 20 hotspots, 19 of them are in the south east of england at the moment including some of the london boroughs. London has the highest case rate per 100,000 of any area of england, even though it is in tier 2. So that is the expectation, and certainly, talking to some people in local authorities, they feel urgent action is needed because case rates have risen so rapidlyjust in the last week. And there is debate even going on about whether it needs to be tier 3 with extract restrictions to try to curb what looks like a rapid spread of the virus. 0ur Political Correspondent helen catt is in westminster. A difficult decision and a political one . It is, we should be hearing from matt hancock later this afternoon, he is due to give a statement to the house of commons. But as you heard just now, there was a briefing earlier this morning for mps from london and also from some of the surrounding counties like kent and essex. Im told the picture that was painted was pretty bleak, they were told cases were rising exponentially, one mp saying the figures were alarming and while there wasnt any specific discussion about moving areas tier 3 or not, as west put it, they might not have set it in words but they did say it in figures. There were some concerns raised earlier too, one mp asking, why they did not seem to have been any impact on the rights in kent, which Went International lockdown and came out into tier 3, why that didnt seem to have had an impact and there were also concerns raised about this plan to relax some of the guidelines on household mixing over christmas. The Prime Ministers official spokesperson has said there are no plans to review the christmas guidelines although i did urge the public to continue to be cautious and to follow the guidelines. They did urge. About a hundred gp practices in england are receiving doses of the Pfizer BiontechCoronavirus Vaccine today, to start immunising patients over the age of 80. The surgeries will operate seven days a week, from 8am to 8pm, and people eligible for a jab will be contacted by their gp. Theres some flash photography in sophie hutchinsons report. Batches of the Coronavirus Vaccine being prepared for delivery today and this warehouse in the midlands. Each box here contains almost 1000 doses and this centre has distributed more than 40,000 doses this morning. The vaccine is being taken to more than 100 gp practices in england, most of their patients will get it tomorrow. But a tiny minority, like the surgery in hell isa minority, like the surgery in hell is a line on the outskirts of birmingham, will have the jabs as early as this afternoon and this gp will be one of the first to administer one of them. Covid19 and the pandemic has been unprecedented in the nhs. We have used to delivering a mass vaccination, we do the flue Programme Every year, this isa the flue Programme Every year, this is a different vaccine, yes, logistically it is different in terms of how we handle it and deliver it but we feel so ready. Gps have to work at speed. The vaccine has to be stored at ultra low temperatures. It is then thawed out and practices have just temperatures. It is then thawed out and practices havejust three temperatures. It is then thawed out and practices have just three and a half days to use it. This one in Central London is aiming to vaccinate as many as 1000 people in the next few days. That will mean injecting up to 40 patients every hour. Nevertheless, many will have to wait for hour. Nevertheless, many will have to waitforan hour. Nevertheless, many will have to wait for an appointment, and doctors are urging people to be patient. Inevitably, with the relatively small number of centres, not everybody will have access to it straightaway. But over the months working through the list, the expectation is that perhaps the 30 million or so people in the country that acquire the vaccine will actually receive it. The rollout to gp surgeries comes less than a week since Margaret Keenan made history by becoming the first person to receive the vaccine as part of the nationwide roll out. People aged 80 and over along with Health Care Staff are being prioritised in what is the largest Immunisation Programme the nhs has ever undertaken. Its taken a huge amount of work, lots of people with lots of different backgrounds and experience. We worked with scientists, people from the army, supply, scientists, people from the army, supply, logistics, estates, all sorts of people who have come together to make sure that we can offer vaccinations as gps come as pharmacists come as nurses, so we are pharmacists come as nurses, so we a re really pharmacists come as nurses, so we are really very lucky and its been are really very lucky and its been a phenomenal endeavour so far. And some gps will be running a mass vaccination programmes from larger centres, such as this one at epsom racecourse. Nhs staff plan to vaccinate up to 300 patients a day here. To be able to do this at scale and get the number of patients vaccinated in a timely fashion, is really good to do in in a central hub where everything on is on site and set up correctly, where the right precautions are taken and we can be sure it is a safe and quality service. Centres like this are part ofa service. Centres like this are part of a rapid scaling up what will be over 1000 vaccination sites in the coming weeks, in the hope the viruss race may soon be run. Sophie hutchinson, bbc news. A 90 year old woman in South Lanarkshire has become the first care home resident in scotland to receive the Coronavirus Vaccine. Older people in care homes and staff have been prioritised in the vaccine roll out. The Health Secretary for scotland said distribution of the vaccine to care homes was a challenge, but she was delighted the programme had begun. This from our scotland correspondent james shaw. You might end up with a wee bit of a bruise. Oh, im full of bruises anyway. An historic moment over in seconds. Hey well done. Annie innes, a former carer, became the first of thousands of residents in scottish care homes to be given the pfizer vaccine. The start of a process which should allow a return to some sort of normality. Oh, its been a terrible year, terrible. I would like to see it a lot brighter for everybody else then. All 52 residents and the staff who look after them at abercorn house care home in hamilton will get the vaccine. In this Health Board Area alone, there are nearly 9000 residents and carers to be vaccinated, a huge logistical challenge. The last week has been really, really challenging. Just trying to overcome each of the logistic hurdles that has come at us with this vaccine. However, the staff across lanarkshire, across the so far, scotland has enough doses of the vaccine for around 33,000 people to get a first injection and then a booster three weeks later. Much more will be needed just to protect those most vulnerable. Over a period of time, particularly once we get for the oxford and the moderna vaccines, the space and the pace will be able to be increased. We are all working as fast as we can but it will be a slow start and then gathering speed. The process of protecting people from coronavirus and ending the long nightmare of the pandemic has begun but no one yet knows how long this beginning of the end will take. James shaw, bbc news, glasgow. For the past 11 months, our medical editor, fergus walsh, has followed the team at Oxford University and astrazeneca as they designed, developed, manufactured and trialled their covid 19 vaccine. This evening theres a special programme in which he charts their progress. Fergus is with me now. This is a remarkable story. They were really quick off the mark. They were really quick off the mark. They design their vaccine over a weekend. They were first to take their vaccine in europe into human trials and now we could be days away from it being approved by the regulator. Now the issue is how do you get the 3 billion planned doses for the world which astrazeneca has promised . I went along to one of the sites where they make it and they grow up the vaccine in human cell culture and it is a bit like watching vaccine masterchef. Their role these people in ultra clean room doing their bit to the recipe. The team at oxford had to find a way to get production up from a Small University level to a huge scale. To get production up from a Small University level to a huge scalem isa University Level to a huge scalem is a little bit like developing the recipe for coke. It takes quite a long time to get the recipe just right but once you have that recipe, it is like a template and it can be transferred to all sorts of different manufacturing organisations around the world and thats exactly what weve done. I hope the programme tonight will reassure people about the speed at which this has been done. There havent been compromises on safety, the trials have been huge, and 0xford actually are ahead of all the other companies in being transparent about its data and publishing it all ina about its data and publishing it all in a medicaljournal. Thank you very much. And you can see ferguss full report in panorama tonight on bbc one at 9 05pm, and afterwards on the iplayer. It is just after it isjust after 1 15pm. 0ur it isjust after 1 15pm. Our top story this lunchtime as coronavirus cases soar, london faces a move to tier 3 englands highest level of restrictions and, coming up, Blood Donation rules for gay and bisexual men are being relaxed across the uk. Coming up on bbc news liverpool will face last years semifinalists rb leipzig in the next round of the champions league. Ill bring you all the details of todays draw as Manchester City and chelsea also discover their fate. The head of the Eu Commission ursula von der leyen had said there is movement in the brexit trade talks. She was speaking as negotiators from both sides resumed intensive discussions in brussels on their outstanding differences. In the last hour, downing street said that a no deal outcome was still possible but that work continues to try and reach an agreement. Jessica parker reports. Where are we going with this . Hopes forfinding a deal go down and edge up again. Arriving to brief ambassadors, the eus chief negotiator. The cameras can follow Michel Barnier out here but not into the negotiating room. Fishing rights still unresolved, also shared competition rules and standards and what happens should they diverge. Today, claims there is movement in the talks but. If the uk wants a seamless access to the Single Market, and the Single Market of the European Union is the largest one in the whole world, they are welcome, but they either have to play by our rules, because this is a matter of fairness for our companies in the Single Market, or the other choice is there is a price on it and price is tariffs. In brussels, four further discussions today, lord frost, the uks chief negotiator. Both sides saying they will go the extra mile. It is what businesses want, it is what people in our country want and that is precisely what were doing. We are not going be walking away from these talks. If we are going to get a deal with the eu, it has to be on the basis that the eu understands that the uk is a sovereign nation and an independent nation. The uk left the eu injanuary but it has been following eu rules and regulations since then while the two sides work towards a future relationship, but there is not long left now until that arrangement expires. Borisjohnson briefed his cabinet yesterday after another phone call with brussels. Both sides agreeing to stretch sundays deadline a little further. So yesterdays deadline came and went and notably a new one wasnt set, but of course there is that ultimate deadline of the 31st of december, in just over two weeks time, when the brexit transition period comes to an end. But a senior uk government source says talks cant go on that late because both sides need time to ratify any agreement. We all want to get a deal over the line. We are up against the wire. The Prime Minister went to the country with one promise a year ago, that he would get brexit done. He as good as said he had a deal. He needs now to deliver on it. But both sides need to keep negotiating, both sides need to compromise. Yesterday, the Prime Minister said a no deal, which would mean new trade taxes called tariffs, was still the