Faction's 2 studies have shown the virus can destroy parts of the immune system that build up protection against other diseases Dr Vella Slava Petrova helped lead the research virus removed in the one memory cells that they had created in response to other pathogen thanks to befall and they also return their system back to a baby like state where they no longer protected to pathogens they've been exposed to before but also they have limited ability to respond to new pathogens university was in the u.k. Have bought strike action of the pay and conditions more than a 1000000 students at 56 institutions could be affected b.b.c. News it's 3 minutes past 8. We are ready for David Cameron 3 to make Boris Johnson referendum the referendum protocol to be meeting on clean renewable backstop so we're going to go out and get these Adrian told me on b.b.c. Radio Hello hello hello in tournaments like breaks it was supposed to have been same but despite Boris Johnson saying you'd rather die in a ditch than see that deadline missed we've now got an extension into January and with an election looming who knows what will happen next so is the fact that will still be in the e.u. At a minute past midnight or how we trick or treat tonight it's time to have your say as we've been together b.b.c. Local radio across England taking your calls on our 800 to one night double to find . Out. Who I laid 100 to 18 double to double 5 v.d.c. Local radio. Such at all it was meant to be bricks day instead we face more daylight and a pretty Christmas election where joining a baby seat local radio getting your thoughts from across England how do you fail tonight be trite all relieved maybe you just be willed it either way I share it with this tonight every change. Mine since the 2016 referendum switch from leave to remain or from remain to leave either way tell me why would you welcome a 2nd referendum should the politicians just get on with it how is the situation making a difference to your job or your prospects to get in touch we're going to get as many callers as we can on tonight between now and 10 o'clock the number to call 80218 double to double 5 that's our 800 to 18 double to double 5 you can text one treble 3 Start your message with the words breaks it on social media using the hash tag b.b.c. England our reporters are covering England tonight and we start on the waterfront in Liverpool I'm clad Hamilton looking over the river messy and there are hopes here that Liverpool's ports could be an even bigger success story if bricks it leads to a stronger trading relationship with the USA from the north to the east harmony homes hearing from aviation experts and passengers at Luton Airport on how this latest pranks to delay will affect our holidays from me in the east to the South Bend voice in haste things East Sussex at this residential language school which teaches English to foreign students now the prospect of Breck's is already changing the market and I'll be finding out how they're adapting from the south over to the west and I'm Jenny Kumar at the sausage factory in Devon on u.k. Sausage week expect no poor keys and plenty of bangers from the West Country later great stuff going to be taking your calls across England tonight oh I don't read too 18 double to double 5 chuckling away Maine a war that's their main their commandment tell us where we are with Briggs. Patria Adrian Adrian it is 3 years 4 months and 8 days to be specific since we voted 52 percent of us to leave the European Union it took 10 months just to trigger Article 50 of the Lisbon Treaty that started a 2 year countdown which ended in March of this year but if you. That's a reason I couldn't get that deal through in fact was the biggest defeat in Commons history at 2 am forced to go cap in hand to the you and asked for an extension that was until tonight the 31st of October spin Northbridge Johnson couldn't get his deal through either much to his frustration he's called a general election the e.u. Have extended it to the end of January and we all weeks away from having another public poll which let's face it may not get us any closer to leaving the e.u. We'll all be home and to reason I called an election in the hope that it would give her a greater role for a teacher to deal with Bragg zing it ended up undermining her and eventually cost her jobs and Boris Johnson is striking a similar gamble now is this going to big a brick city election here absolutely right 2 years ago that's what everybody said that people would be voting based on whether or not they wanted to leave the European Union or stay in it as the weeks progressed tools that's not poll it became very much about bread and butter issues you remember it's a reason May's disastrous dimentia tax that was suggested you remember Jeremy Corbyn being very visible very popular with demographics that were really unexpected instead of consolidating power in the Commons she actually lost her majority and her frustration was never ending then until she was forced to stand down and the conservatives are keen to keep that focus on the e.u. Over this campaign Labor have other ideas they want to replicate the success of 2017 here the Tea Party leaders we are going to deliver a fantastic deal by which this country will come out of the European Union a deal that is try to block and that we will deliver that is the future for this country Kerry for a good under the Labor Party or taking Britain forward to a brighter future under the Conservatives people have a chance to vote for real change after years of conservative unlived damned carts privatisation and tax handouts for the richest this government that's. Porch our n.h.s. Into crisis this election is a once in a generation chance to end privatisation you know you just give it to finally get me so there we go that's libron conservative call being the Johnson what about Bracks it for some of the smaller parties Well Jeremy Corbyn and Boris Johnson neither of them can stand up and say my party's divide is completely united one way or the other when it comes to membership of the European Union the Liberal Democrats can from the very beginning they have been steadfast in wanting to stay in the e.u. The promise of their party leader if we win a general election we will revoke Article 50 there won't even be another vote on it and she believes her party are the only ones with a very clear focus the Liberal Democrats are only are we both Labor and the conservatives in the European elections we have more vendor is than ever before and we have been joined by end he's joining us from both Labor and the conservatives we have a bold vision just don't practice it don't forget though Adrian Do you remember those European elections the ones that were never supposed to happen at the Braggs it Party in the greens they did incredibly well in the Northwest for example the budget party won half of the seats and the independent group change u.k. They might not have been as successful but what they did do is take some votes away from some of the other remain parties what could happen is that the smaller groups in marginal seats which are the ones that in the end have the keys to 10 Downing Street over they could make all the difference in terms of splitting the leave votes or they remain votes let's go to longer plenty more from Nina is a go through between now and 10 o'clock tonight but most of all I wherever you live in England listening to local radio we want to hear from you our 800 to 18 double to double 5 and there is in Blackpool Good evening to you Maria welcome along thank you how are you. It's clear that you want to import business in Port been to carpets and rugs directly from Belgium from the. Right so what do you make of today what has happened today or for the last 2 years. Well 1st of all you say how how we're feeling we're feeling very very weary at the moment. We failed in election was not the way forward we were. Initially of course a result or referendum. In the case of election I don't think any general election should be fought on one issue an unfortunate that's what's been asked of the contraceptive Mary and I wish in the one nation to ask you this is the 2nd deadline where we expected to leave as a small business owner how much have you had to spend just to prepare for these deadlines never actually happen well if we say normally I would have spent last month in the region of around about $5000.00 on start we spent around about $20000.00 on start last month alone. The family we use stockpiling stockpiling with stockpiled Michelin star power for the March 29th deadline we have a business model where we import about once every 6 weeks the situation with not knowing what's happening and deadlines change and has completely changed the business model with how to stop pile then we talked about our suppliers on hold they're very confused in the then with how to stop again. Impact on cash flow and it's had a huge impact on how our suppliers the world and how they're likely to supply in the future some are just really understand what is your concern is that if we had left the European Union for whatever reason your supplies would be disrupted if we left the European Union tonight it would have been in the case of a no deal in the case of a no deal it's. Just a case we had to stop Al Again no deal because we not only import from the e.u. We also can our own goods so we go across and buy in the and that way a comedy hour goes on a roll on roll off situation on the on of cross-channel ferry on the train fortunately right up to one week before no deal to happen they are masses and situ our inquiries as to how would we actually move our goods on the 1st of November in a no deal situation their answer to that one week before that day which we really don't know I asked their advice they said stop and sit tight Wow So that was. Just a few Marriott you are in Blackpool 2 thirds of people in that constituency voted leave Have you found yourself in for all debates when it comes to membership of the European Union or is it one of those issues in Blackpool that you simply can't talk about anymore. Governments divided me from. Small community just myself and my partner. And. It's divided us from friends it's divides us from family. It's a very heated issue. For actually one of the things that does tend to frustrate us particularly if somebody is voted to leave. They do not want to talk about. When we do try to talk about it. Very quickly becomes heated and then one of the issues that we find ourselves facing is we just tired of the whole thing we don't want to be bothered anymore now for people like us been waking up every morning going to bed every night waking up in the middle of the night trying to work out what will happen next to our business that we spent 20 years building it's not really a such as factory answer I'm very emotional as families open down the country who are divided into 2 I hope it works out the America one way or the other and you look around you that you have that margin where you can stockpile and bring in William and Charlie in Lancaster. Hi William hello there hi yeah go on what's your take on the fact that we're not leaving the European Union tonight William. Well this appointed really because I think when we voted to go out and leave that was our policy I am no problem with that are gone out of the way and I would absolutely contend if we to stop or we will leave that's a majority and that's the way I think you heard Maria that talking about the need to stop poly in the event of a no deal Brack see you prepared for the fact that the business model had a real rough ride of it in the event of another deal breaks it. Well you do it you know. Where you called your you know I'm called Adrian I'm presenting the show. And let me just tell you yeah I'm 72 I don't get it really well actually Don't you care about the people who leave any country might be really businesses like Marie who are facing hard times. I cared about my children well banks very much indeed for your go let's move on let's break it to him Squires is from Squires gear in engineering Coventry a small firm supply in the car industry. Good evening interesting William there saying he doesn't give a. Shit about your business can you see why. No not really. The last comment was he cares about his children. I'm truly lucky children. So I would tell. Very interesting take on things what do you tell us a little bit about your company Tim and how you would have been impacted if we'd left the European Union obviously we don't know whether it would have been a no deal breaker whether a deal could have been agreed because the business with a droll agreement Bill being put through parliament so it's possible the model been a dale but tell me how your business works and how it might have been impacted and how it might still be impacted if and when we leave the European Union Yeah. Manufacturing companies. We supply predominantly that's for the automotive industry . We've got about 30 percent of our goods on a monthly basis go out to Europe Italy and Switzerland and the rest of our parts get. Them I just think that we want to move forward was a no. The u.k. Is not the most cost effective nation in the world to manufacture goods and our customer certainly in Italy was out a very frank conversation with me and said look you know. If this terrace that we're going to be put on for your goods we're not going to be. So on our that we would have to extricate us or. They would randomly start one not randomly they would certainly. Look for a new supplier so just so we understand that Jim because not everybody my understand the way business works at the moment in the European Union there are no tariffs no extra taxis on your goods if you trade between one e.u. Country in another if we're going to with a no deal Bragg's it then you would have had World Trade Organization rules which would have bought tariffs i.e. Taxis on the movement of goods from the u.k. To the e.u. And that would have made your goods more expensive Yeah that's right I mean we were very very handsome compete in a global market where you know. The kind of companies that we compete against across the world have much lower White use than what we do here in the u.k. And there are able to manufacture goods a lot a lot cheaper than what we can. But yes and only if if there's this scenario where tiresomely and puts on my can are good small more expensive than what they currently are rapidly you'll find that customer base will start looking to it to treat the source's to source their goods from that was a major thing. Certainly our company and I knew most of the companies were really really trance of OJT Yeah so the idea that the people might voted to leave the European Union at a broader level you're you're relaxed with that but please let's not have a no deal breaker that's the thing that would be really dangerous and damaging for . Business yet but might the major thing was that what we're trying to avoid obviously as a company when we really hopefully with a deal with the deal that we've got on a good deal hopefully it's as quick as possible because the major impact on business at the moment is this uncertainty it's starting to slow down business projects aren't going to hurt investment the slide down dramatically across the board and till breakfast is done and dusted and people can start moving forward that isn't going to change I'm interested to know Tim with the general election community will the fact that we are still in this bigotry when it comes to finding it the leading without one without affecting the 4. Yet very much so strange I mean from the last and yes I mean certainly we've Jeremy Corbin stance of. Putting things off for police he was looking for another 6 months he wanted to put it to another photo again etc etc I mean myself we are to remain in the European Union however. More than happy to go with the consensus the majority of the country votes it's a link so we'll go with that but certainly dragging it out for more and more time is discounted be more and more detrimental to the u.k. Business and this. Callers have said previously to now that I've been listening to . It it's gone on long enough and it can't go on any longer amount to drag out even for. It's not the white do things to really push a time tonight thank you Tim Squires manufactory in Coventry going to get as many of your calls on as we possibly can on b.b.c. Local radio across England on the day that we were told was going to be the day the u.k. Leaves the European Union that's now been put back to January who knows with an election looming what ultimately might happen give us a call 800 to 18 double to double 5 a text I want trouble 3 Start your message with break seats let's bring in class Hamilton he's our Merseyside political reporter is an interesting region isn't it Clapham many reasons but not least because 3 Blair is there feted leaves 3 voted remain we just heard from Tim in Coventry he voted remain but at the moment he's thinking of backing the conservatives because he's so fed up with Labor's stance on Bragg's it are you hearing any of that on the side in such a traditional Labor heartland. No I'm not. The site is about as red as it gets when it comes to politics in this country the parts that I cover only house one no one Labor m.p. The South Pole which is represented by the conservatives I think it would be a reasonably hard sell for the conservatives to pick up votes at the general election particularly in Liverpool but of course as he says Hoffa pretty much half of the Liverpool City region did vote leave in the referendum so this election that's coming up is going to be a really exciting one in previous years there's been you know less excitement because people thought that they could predict the result and it's turned out to be as I predicted at this time people are feeling there's more up for grabs there's more possibility of things changing and certainly being interesting and the Bracks it Party really I went to Southport a few weeks ago there were lots of people talking about the possibility of that party picking up votes he almost he said I'm speaking to you tonight from the majestic Liverpool waterfront I'm overlooking the mess he's standing on Liverpool's iconic waterfront with its fabulous listed buildings the 3 Graces the take gallery is to my left the Kummel the lead ship yards over the water from me and has in a way to my right is the port of Liverpool now in the late 19th century this place helped Liverpool become the 2nd city of Empire trade building for 8 people but in 1073 when Britain joins the e.c. There was an argument from some people he said that because of the geography the city would lose out to southern ports and in fact in the $97.00 seas Liverpool's fortunes to take a bit of a nosedive but that's what's changed now in the city is being the port is the 4th largest in the u.k. By tonnage of freight there's going to be a new cruise line a terminal not far from where I'm standing now and tourism is huge business all of that is helped aided and abetted by this. And I'm joined on this rather cold following tonight by Chris shelling recuse the chief executive of mezze maritime which is the representative body for the maritime industry in the Liverpool City region Chris how big a deal is this refer to this area I think when we talk about maritime I think it's useful to not just think about ships and ports and shipyards mark time for this Liverpool City region as worth about 4200000000 a year and employs some 52000 people and this incredibly influential impactful industry could surprise so many subsectors professional services universities and Jeanette companies offshore wind energy it's all time so. It is our lifeblood being based in Liverpool we have the as