London cab I'm not the problem in any way shape or form the problem lies elsewhere . Anyway who knows when I go to back to this in the future Mark Forrest is next on b.b.c. Essex I hope you have a very good evening and join me tomorrow for. 30 years of B.B.C.'s it. Seems to be the easiest thing. Pvc news at 7 o'clock I'm sorry Loughton the Queen's offered her congratulations to Team g.b. On what she described as their remarkable achievement Downing Street says there's no limit on the number of British athletes who may be given on as it's been the U.K.'s most successful Olympics for more than a century the head of team g.b. Markings and says there's a generation of young athletes aiming for medals at the 2020 Tokyo games there's no reason why given the investment with his continuing given that the breadth of sports that quite quickly we have now investing in and returning with medals and the the appetite in life from being a white guy that way every confidence that I can try and be a child again with something that will actually be a high gain for Taliban you know be a real appetite to try and do as well again we feel the swimwear manufacturer speed 8 has ended its sponsorship of the American star Ryan Lochte over his false claim that he was ropes its gun point in Rio The firm said it could not condone his behavior the former Radio one d.j. Christan in his view to guilty to 21 sex offenses many against children committed more than 30 years ago he denies 3 other offenses the 75 year old is already serving a prison sentence for other assaults. People in Germany may be asked to stockpile food supplies in case of a terrorist attack all natural disaster the plans will be discussed by the German cabinets this week as Jenny Hill reports for the 1st time since the end of the Cold War German citizens are being told to prepare for the West the proposed civil protection strategy is believed to recommend that household stockpiled enough food to last 10 days and to ensure they have a sufficient supply of water the country's interior minister told a group of schoolchildren the Gemini must be prepared to react if water or food reserves a poisoned or if oil and gas supplies are interrupted and Islamist militant has for the 1st time appeared before the International Criminal Court in The Hague Ahmed al faqih al Mahdi has pleaded guilty to destroying cultural heritage in the West African city of Timbuktu and 2012 the chief prosecutor is Fat see Bensouda but eradicating the music only arms was. Intentionally this fraud something that is intangible in measurable. Comes from the book the region and as it is old was fully aware of the importance of the Muslims and this significance to the city's inhabitants known operations will be scaled back during the winter to help in h.s. Emergency departments cope with extra demand the Department of Health says it will put more resources into emergency units ahead of Christmas the weather rain will move into the Northwest even ice for the south it will be fairly dry with some folks patches b.b.c. News at 3 minutes past 7. And there is the weekend behind is which together was called just after 7 o'clock hope your weekend was down Bismarck Well a badly run for about. Over the weekend. If you need cash and have you ever considered. Well thousands do. You. Figure if. You're about to hear. Do you want to drive. 20 miles. The country's biggest mountain range. the week before with our life reporter. Seem to be sitting on Copacabana beach so how we actually got to see anything because you couldn't watch the triathlon which took place there that happened as I discussed with you on Thursday during my commute into do the show as I recorded it or what a pleasant Saturday afternoon that was watching about 3 or 4 hours of it back yet including the hour beforehand on the hour afterwards even though the event and he takes 2 hours it was worth spitting it out for every last 2nd and he was just as good got lots of interesting stories to share with you starting with this and you ever been involved in a clinical trial I ask because more than half a 1000000 people in the West Midlands alone have taken part in such a trial over the last decade which is more new recruits than in the whole country Jonathan Sheffield is chief executive of the National Institute for Health Research is on the line Jonathan Good evening good evening fascinating numbers how many people in this country take part in clinical trials each year. Well every year we recruit over $600000.00 patients into clinical trials in England in the n.h.s. Huge huge numbers what type of trials would they be taking part in it's a vast range so we can start off with studies looking into people's diet and eating habits to see if there are any indications about diet that may cause problems later on in life but also some very detailed investigation studies into cancer new drugs and new treatments for cancer across the whole range at any one time the National Institute for Health Research is running about $4000.00 trials in the n.h.s. In England and the research for me is that said straight back to the big drug companies who might be bringing forward new drugs that can help treat us in the future so we do work with big drug companies but that's actually quite a small percentage of the total work we do only about 10 percent of all the patients we recruit are recruited into studies that we're working with drug companies an awful lot of our research is the n.i. Char National Health Research is own research which is usually in areas of disease where there's not much funding for from Big Pharma all from the charities so mental health research we do a lot of mental health research within the network but also we support all the large medical research charities arthritis research u.k. Cancer research u.k. a Whole range of different charities that also fund clinical research in the n.h.s. So it's a very broad spectrum how important are these clinical trials in the human involvement and all the other ways we could get the same results we have to do the trials in humans that's absolutely that's how we prove the concepts that have been developed in the lab or a trace And so this is a very carefully regulated area starting with what's called phase one trials which are the 1st. Asked in Human Being trials and those are in very controlled tight and violence having already done lots of experiments with in the laboratories to look at the safety and efficacy of the drugs and actually introducing the the new drugs in very small doses to make sure that no abnormal reaction once those trials have been successful and there's no obvious complications and those trials those phase one trials with them move into phase 2 which is then started to look at people with the disease and just exactly how much of those types of drugs we require to have an effect and then finally the thing where we recruit the large numbers of patients or ones to try once the drug has been shown to be effective but wanted to look at the whole population so recruiting hundreds of patients into these clinical studies to prove that it works be that there are no unforseen consequences of using drugs Well I must emphasize is that all patients that get involved in clinical trials are given fully informed consent as they everything's explained to them the potential complications explained and then we get that consent you do not have to participate in in the trial the tool so to speak up on the potential complications I mean what all the risks of taking part in these trials well to be honest the risks are very small so we've had very few complications over the last 10 years at the end at the end I charged been running these trials and in actual fact people do get abnormal reactions to drugs even when they're not in a trial so what you try to do is make sure that you pick up any of these complications and these people are very carefully observed so that the thing about a clinical trial is it's a very controlled environment with extra detail being put into checking up on people and making sure that there aren't any complications showing and if there are complications trials or stop this constant ethical review of the way things are going so it's incredibly rare for any complications to come out of these trials and it's incredibly rare that we are. To get real problems with trials can really problems actually mean fatalities. In our clinical trials that we've performed in the last 10 years we've not had any fatalities at all and if you look at the complications that you get from routine treatment then I think that shows that the the area of clinical trials is so well regulated by the 600002 have you ever been one of those 600000 have actually yes so that the area that I've been involved in is in dementia research I'm clearly not dementing now but we are really interested in looking at the chronic disease conditions of of the elderly and so we have. Announced today working with the Medical Research Council the world's most in-depth study to detect early signs of out so I missed disease and things that people who are listening to this program could get involved in themselves so we have a Web site join dementia research at an eye doc. But if you just Google joined dementia research all runs into one word there's a. Website there where you can get information about how you can become involved in dementia type studies and we're looking for not just people with dementia but people who are carriers of people with dementia but also healthy people who may to later date in life develop dementia and what we're looking for is what all the factors in their life might indicate that tendency to develop dementia so that there's an awful lot of research we're doing which is trying to predict whether or not people will get diseases and what we can what interventions we can bring to prevent those diseases we can think about side as well thank you so much Jonathan Jonathan Sheffield from the National Institute for Health Research $600000.00 just over a year take part in cynical trials that they organize I'm going to meet somebody who's involved in a clinical trial right now. Have to Billy Joel and tell her about. The trial drug might make your life a little. Shake it. Was just. So. Let me let. Me. Bring. In the. Flu. Julia. Would Say. That it. Was. A. Way. To. Get in touch with the shell this guy number 345358 Billy Joel and Teller about it you can take the show. The message extended message rights apply email me Mark at b.b.c. Talk to u.k. On social media just search mark for a show on Facebook Twitter that we are I was astounded by those numbers over 600000 in this country every year take part in a clinical trial what's it like Monica Debbie is from Coventry Hi Monica. You have a gastro intestinal condition called all sorts of collides us do you know what trials have you taken part in and the 2nd part and nothing. Really at the trial and. And. Obviously not the she dish no medication but still arsenic stroke and unfortunately they haven't worked for me but I am on a new one now that just started Ok what form do these trials take is it is a question of taking away some meds that hasn't actually been put on on general use no pm the previous ones have been in drip forms so I have to go in to hospital not the drip the one I'm on now is an injection form and how many of us are you to take something which is just being trialed. Obviously I am nervous and they have obviously do have failure as you don't know what the side effects are going to be but the way I see obviously even with the license strokes you don't know what effects are they going to have on you as it's different for everyone and your motivation in doing it is it financial or is it in the hope that they will work for you make you feel better it's because the traditional medication didn't work for my health and I was at a point where they told me that my only option would have been surgery and obviously does not the route I wanted to go down and so when the trial was offered to me are always more than happy to try it because a good isn't want to have surgery and we just heard from the chief executive of a National Institute for Health Research who says doctors all very careful to get informed consent from patients but what's that process mean for you and obviously they tell you all the risks they tell you the potential side effects and say You're while informed before you do take part and. It is a case of then once you're told of all the risks if you want to participate or not is entirely your decision and is there any payment. The one the trial I'm on now is just literally your car parking fee for giving back and mileage to and from the hospital that sit on a supposed you not only helping yourself potentially these do all of these drugs for your trolling you you could be helping many other people exactly I mean if people don't put themselves forward for these cars and we're never gonna know obviously if they work and haven't lived with this condition for 3 years I know it can impact your life so if it can help with the people who are not brilliant and how long typically does a trial last if it works for you. Some of them could last a year 2 years. But I suppose yes if it's if it's going to make the condition easier to live without God I gotta say I know a little bit about. A friend of mine when I was younger I suffered from a form of the disease but it can be extremely uncomfortable. Actually every day like when you go you can't. 2 times you can email you say yes no maybe not I will go out with a trial I hope it works for you monocoque you really nice day for me I'm on a cadaver you from Coventry who is actually taking part in one of these and it has clinical trials at the moment those are the only sort of trials you can check. There are all these run by drug companies that might. Figure. It out one of them after. We talked about clinical trials $600000.00 plus volunteered to take these trials every year in this country now it makes perfect sense if you're in Monaco situation Monica's in Coventry she has a debilitating condition she's had it for a couple of years she says the way she looks at it if it's going to help or she's going to take the trial but what if you're in perfect health would you just do it for money Joining me now is freelance journalist Jack Hutch craft he went undercover on one of those trials for online magazine vice chairman evening good evening now you come horror I mean more to the point how you having gone through this and what led you to want to try it out. Well basically the idea of a piece about what kind of people would go to do this because I was like I'm quite health conscious I didn't really want to go in there blindly I thought I'd approach some friends of friends of friends who were you had do it themself or they didn't want to go on record and the very very secret thing it seems to be so I thought what better way of meeting people who do this than to go do it myself so. So I went in I went through and what sort of drugs were they trial and what what were they going to put into you or they were trialing. Like a painkiller that works with the cannabinoid receptors in your brain for off the arthritis it was in the very early stages. In the early stages and then you go through those and then you go for next April and eventually to work towards easing people's pain that got us so your day right in the beginning your the early stages it really hasn't been tested very much at all did you not walk into that facility thinking oh my goodness 10 years ago London Hospital 2006 you remember those 6 healthy young man that organ started shutting down their brains caught fire in their eyeballs were going to pop out when it went through my mind almost hourly when I was in the right waiting room. You know I mean life the risk is and. So I went for and then it crossed my mind and then I did a bit of research while I was in there and found out the same hospital It happened in and then one of the guys all speaking to He'd been on the same course as these these guys 10 years previous and so at this point I started to worry a little bit well you know are committed to it by then so that's extraordinary So one of the people that with you had been on that extraordinary trial the Elephant Man trial. And came back Chen really Jack what kind of people were there with you taking the money to have goodness knows what injected into them. Yeah well it seemed like I was expecting a lot of desperate students are you know uni graduates you hadn't yet found a job or in fact it was a big a smorgasbord of people really very different people I spoke to I spoke to a list guy he was. He was it was in naff a kind of I mean he got paid really well what was in that almost true. Reasons and he was like oh my body just a vessel and if I can help people out why not I spoke to the people who were guy had been in jail he said. How to get a job and to be honest being in. 2 weeks time was in 3 different to being in jail for weeks to do him it didn't seem too different very different people I also did meet a young student who hadn't told their parents and this kind of thing goodness gracious what's the money like me talking about people making a lifestyle choice here if you're in that will give me a for example how much well well I got one of the guys in the phone 26 you had been in there for 26 days which is. In the scheme of things not an excessive one he got 4500 and he said he didn't twice yeah 2 or 3 times yeah I used to go to holiday all the time afterwards and used the money for a spiritual retreat and I thought something sinister to make a lot more are you counting that for a couple of couple of days so I only got files and quite I mean a lot of money a 1000 quid for 2 days is what have you would you do it again. I wouldn't you know I didn't realize how much I didn't like needles until I had them go in and out of my arms all day long I looked out my arms and it was 2 in each arm and I felt a little bit queasy so it was for the sake of the article I did it but I wouldn't do it again but apart from that craziness. That craziness I mean any other after effects. No I felt fine Interestingly enough there is a ball or 2 placebos in the like in the story so no one knows if you got the placebo or not I know everyone else seemed to feel fight the end I felt fine you mind your mind complete tricks on you so I tried not to overthink it and I lived to tell it really interesting thanks Chad great to talk to you Jack Hutch craft a musician and journalist who put himself on to one of these clinical drug trials he did 2 days got just over a 1000 pounds the guys doing up to 26 days for 4 and a half 1000 pounds and that guy does it 3 times a year and then goes on holiday What's a right 13 and a half 1000. 3 months in hospital. Would you do it. In 950 he was in the Army and was told the room did to be divided 5050 they were going to try a new drug for flu he didn't get a placebo added up in hospital for a 50 days with flu boy. But I suspect. A lot of money. Between junction. And junction. Junction. Both directions. 123. 4. Weeks. Trial getting holidays. Or 3 phase time. If you just a couple of days. As well from the visit. By the night what do you like driving through very very very long tunnels noice huge fan Martin is in Pendle Martin he's been in a Norwegian tunnel that is 16 miles long 2 way and single boar not found out bit scary there's nowhere to go is there something goes wrong in the wonder you're in Gemini how you about them they have lots of them on the continent would you like a few more of them in this country 81 triple 3 is the text start your message Mark why do I ask you this question well it's one of the biggest road projects in the world this tunnel which has been proposed underneath the penance