April 14, 2021 Preface It is in the United States’ strategic interests to ensure that the world mobilizes effectively to end the SARS-CoV-2 pandemic. A proactive U.S. role is essential to secure the gains underway in the United States and ensure Americans’ health, safety, and prosperity into the future. Helping to secure the future of lower- and middle-income countries is also simply the right thing to do, on humanitarian, economic, and security grounds. Today, the United States is quickly approaching a moment of genuine promise, when exceptionally effective vaccines, accelerated distribution at home, and an enlarged American vaccine industrial base open the door for the Biden administration to bring American leadership to urgent global vaccine challenges. The United States’ health, economic, and national security interests argue for seizing this moment, beginning with presidential leadership to explain the stakes to Americans still legitimately worried about the epidemic at home. The United States ignores at its own peril the acute threat posed by viral variants, geopolitical rivals who take advantage of the moment, and deep vaccine inequity around the world. By sharing American vaccine resources starting at the soonest possible moment, the United States can claim ascendancy against these risks. That essential step should be part of a four-part U.S. diplomatic strategy that will: