Thairo Estrada hit a go-ahead three-run homer in the fifth inning and singled twice, Luis Matos drove in a career-high five runs, and the San Francisco Giants beat the Colorado Rockies 10-5 for their sixth straight victory at home in the series. Matos and Matt Chapman also had three hits apiece for a refreshed San Francisco squad coming off its first off day following 16 straight games. Jordan Beck homered in the second inning for Colorado and Ryan McMahon had a two-run double in the first as the Rockies began the game with four straight hits.