Ovarian Insufficiency Raises the Risk of Osteoporosis by Angela Mohan on March 3, 2021 at 11:28 AM Menopause, the journal of The North American Menopause Society (NAMS). Osteoporosis is a skeletal condition characterized by low bone mass and deterioration of bone tissue that leads to fragility and an increased risk of fracture. The debilitating disease, which affects more women than men, is associated with significant morbidity and mortality when osteoporotic fractures occur, leading to an increased rate of institutionalization and risk for mortality. Previous studies have suggested an association between osteoporosis and POI, which is the loss of ovarian function before age 40 years. This new study, however, is the first one done on a larger scale, with more than 12,000 participants.