Notable Heroes in Health Care: Multisystem Inflammatory Syndrome in Children (MIS-C) team Children’s Wisconsin Share Number of years working in your current industry: From the beginning of the COVID-19 pandemic, a main understanding was that it usually doesn’t affect children as seriously as adults. While that remains true, in early May reports of a “mysterious illness” in some kids who have been exposed to COVID-19 started to emerge. Known as “Multisystem Inflammatory Syndrome in Children” (MIS-C), kids can present with many different symptoms, including a persistent high fever, swelling of the hands and feet, rash and red eyes and tongue. Some have also been found to have inflammation of many organs —including the heart.